Skip to main content

Acacia nilotica (L.) Delile. (Fabaceae/Leguminosae)

(Syns.: A. arabica (Lam.) Willd.; A. vera Willd.; A. scorpioides W. Wight; Mimosa arabica Lam.; M. nilotica L.; M. scorpioides L.; Vachellia nilotica (L.) P.J.H. Hurter & Mabb.)

  • Chapter
  • First Online:
Handbook of 200 Medicinal Plants

Abstract

The translucent gum of a tropical shrub, found throughout tropical Africa, India, Iraq, and West Indies, is chiefly composed of calcium, magnesium and potassium salts of polysaccharides. It has been used for centuries in traditional medicines, by Egyptians and other Arab physicians. British Pharmacopoeia describes gum acacia as a source of useful medicaments. Gum Arabica is very brittle, nearly scentless and bland in taste; soluble in water and insoluble in alcohol, ether and oils. The gum is ascribed astringent, demulcent, emollient, antiseptic, tonic and nutritive properties, and is used for irritated conditions of mucous membranes, such as cough, sore throat, chronic bronchitis, diarrhea, dysentery, leucorrhea, cystitis, urethritis, gonorrhea, burns, sore nipples, inflammations and nodular leprosy. It is primarily indigestible in humans, and extensively used as food additive. Chief use of the gum in pharmacy is as an emulsifying agent to suspend insoluble powders in aqueous mixtures, and as a binding agent to make pills and tablets specially cough drops and lozenges. It is commonly employed as a demulcent in preparations designed to treat diarrhea, dysentery, coughs, sore throat and fevers. A paste of the gum with egg white is applied in conjunctivitis, and is also reported to be useful as food for diabetic patients. Pounded tender leaves into a pulp are also administered in dysentery and diarrhea; the leaves decoction used as gargle is useful in spongy gums and relaxed sore throat, and to wash hemorrhagic ulcers and wounds. Decoction of leaves and pods is dried and made into tablets, and is known as Aqaqia . Gentamicin-induced nephrotoxicity in rats was significantly ameliorated by pretreatment and concomitant treatment with gum Arabic, in part, due to reduced oxidative stress. Gum Arabic is reported clinically useful in cases of chronic renal disease, especially the End-Stage Renal Disease (ESRD) requiring renal dialysis; and, administration of gum Arabic is also reported to decrease TC and LDL-C in mild hypercholesterolemia.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 299.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Abd-Allah AR, Al-Majed AA, Mostafa AM, et al. Protective effect of Arabic gum against cardiotoxicity induced by doxorubicin in mice: a possible mechanism of protection. J Biochem Mol Toxicol. 2002;16:254–9.

    CAS  PubMed  Google Scholar 

  2. Al Mosawi AJ. Six-year dialysis freedom in end-stage renal disease. Clin Exp Nephrol. 2009;13:494–500.

    PubMed  Google Scholar 

  3. Ali AA, Ali KE, Fadlalla AE, Khalid KE. The effects of gum Arabic oral treatment on the metabolic profile of chronic renal failure patients under regular hemodialysis in Central Sudan. Nat Prod Res. 2008;22:12–21.

    CAS  PubMed  Google Scholar 

  4. Ali BH, Al-Qarawi AA, Ahmed IH. Does treatment with gum Arabic affect experimental chronic renal failure in rats? Fundam Clin Pharmacol. 2004;18:327–9.

    CAS  PubMed  Google Scholar 

  5. Ali BH, Al-Qarawi AA, Haroun EM, Mousa HM. The effect of treatment with gum Arabic on gentamicin-induced nephrotoxicity in rats: a preliminary study. Ren Fail. 2003;25:15–20.

    CAS  PubMed  Google Scholar 

  6. Ali BH, Al-Salam S, Al Za’abi M, et al. New model for adenine-induced chronic renal failure in mice, and the effect of gum acacia treatment thereon: comparison with rats. J Pharmacol Toxicol Methods. 2013;68:384–93.

    CAS  PubMed  Google Scholar 

  7. Ali BH, Ziada A, Blunden G. Biological effects of gum Arabic: a review of some recent research. Food Chem Toxicol. 2009;47:1–8.

    CAS  PubMed  Google Scholar 

  8. Ali BH. Does gum Arabic have an antioxidant action in rat kidney? Ren Fail. 2004;26:1–3.

    CAS  PubMed  Google Scholar 

  9. Al-Majed AA, Abd-Allah AR, Al-Rikabi AC, Al-Shabanah OA, Mostafa AM. Effect of oral administration of Arabic gum on cisplatin-induced nephrotoxicity in rats. J Biochem Mol Toxicol. 2003;17:146–53.

    CAS  PubMed  Google Scholar 

  10. Al-Majed AA, Mostafa AM, Al-Rikabi AC, Al-Shabanah OA. Protective effects of oral gum administration on gentamicin-induced nephrotoxicity in rats. Pharmacol Res. 2002;46:445–51.

    CAS  PubMed  Google Scholar 

  11. Almas K. The antimicrobial effects of seven different types of Asian chewing sticks. Odontostomatol Trop. 2001;24:17–20.

    CAS  PubMed  Google Scholar 

  12. Al-Mosawi AJ. Acacia gum supplementation of a low-protein diet in children with end-stage renal disease. Pediatr Nephrol. 2004;19:1156–9.

    PubMed  Google Scholar 

  13. Al-Mosawi AJ. The use of acacia gum in end-stage renal failure. J Trop Pediatr. 2007;53:362–5.

    PubMed  Google Scholar 

  14. Anderson DM, Millar JR, Weiping W. Gum Arabic (Acacia senegal): Unambiguous identification by 13C-NMR spectroscopy as an adjunct to the Revised JECFA Specification, and the application of 13C-NMR spectra for regulatory/legislative purposes. Food Addit Contam. 1991;8:405–21.

    CAS  PubMed  Google Scholar 

  15. Anderson DM. Evidence for the safety of gum Arabic (Acacia senegal (L.) Willd.) as a food additive—a brief review. Food Addit Contam. 1986;3:225–30.

    Google Scholar 

  16. Anderson DMW, Dea ICM, Daramalla KA, Smith JF. Studies on uronic acid materials: XXIV. An analytical study of different forms of the gum from Acacia senegal Willd. Carbohyd Res. 1968;6:97 (Biol. Abstr. 50:15973).

    Google Scholar 

  17. Andrikopoulos NK, Kaliora AC, Assimopoulou AN, Papapeorgiou VP. Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation. Phytother Res. 2003;17:501–7.

    CAS  PubMed  Google Scholar 

  18. Anonymous. Final report of the safety assessment of Acacia catechu gum, Acacia concinna fruit extract, Acacia dealbata leaf extract, Acacia dealbata leaf wax, Acacia decurrens extract, Acacia farnesiana extract, Acacia farnesiana flower wax, Acacia farnesiana gum, Acacia senegal extract, Acacia senegal gum, and Acacia senegal gum extract. Int J Toxicol. 2005;24 Suppl 3:75–118.

    Google Scholar 

  19. Bachmann E, Weber E, Post M, et al. Biochemical effects of gum Arabic, gum tragacanth, methylcellulose and carboxymethylcellulose-Na in rat heart and liver. Pharmacology. 1978;17:39–49.

    CAS  PubMed  Google Scholar 

  20. Calame W, Weseler AR, Viebke C, et al. Gum Arabic establishes prebiotic functionality in healthy human volunteers in a dose-dependent manner. Br J Nutr. 2008;100:1269–75.

    CAS  PubMed  Google Scholar 

  21. Chinsembu KC. Ethnobotanical study of plants used in the management of HIV/AIDS-related diseases in Livingstone, Southern Province, Zambia. Evid Based Complement Alternat Med. 2016;2016:4238625.

    PubMed  PubMed Central  Google Scholar 

  22. Clark DT, Gazi MI, Cox SW, Eley BM, Tinsley GF. The effects of Acacia arabica gum on the in vitro growth and protease activities of periodontopathic bacteria. J Clin Periodontol. 1993;20:238.

    CAS  PubMed  Google Scholar 

  23. Codipilly CN, Teichberg S, Wapnir RA. Enhancement of absorption by gum Arabic in a model of gastrointestinal dysfunction. J Am Coll Nutr. 2006;25:307–12.

    CAS  PubMed  Google Scholar 

  24. Collins TF, Welsh JJ, Black TN, Graham SL, Brown LH. Study of the teratogenic potential of gum Arabic. Food Chem Toxicol. 1987;25:815–21.

    CAS  PubMed  Google Scholar 

  25. Doi Y, Ichihara T, Hagiwara A, et al. A ninety-day oral toxicity study of a new type of processed gum Arabic, from Acacia tree (Acacia senegal) exudates, in F344 rats. Food Chem Toxicol. 2006;44:560–6.

    Google Scholar 

  26. Eltayeb IB, Awad AI, Elderbi MA, Shadad SA. Effect of gum Arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers. J Antimicrob Chemother. 2004;54:577–8.

    CAS  PubMed  Google Scholar 

  27. Gamal el-din AM, Mostafa AM, Al-Shabanah OA, Al-Bekairi AM, Nagi MN. Protective effect of Arabic gum against APAP-induced hepatotoxicity in mice. Pharmacol Res. 2003;48:631–5.

    Google Scholar 

  28. Gazi MI. The finding of antiplaque features in Acacia Arabica type of chewing gum. J Clin Periodontol. 1991;18:75.

    CAS  PubMed  Google Scholar 

  29. Haskell WL, Spiller GA, Jensen CD, et al. Role of water-soluble dietary fiber in the management of elevated plasma cholesterol in healthy subjects. Am J Cardiol. 1992;69:433.

    CAS  PubMed  Google Scholar 

  30. Hegazy GA, Alnoury AM, Gad HG. The role of Acacia arabica extract as an antidiabetic, antihyperlipidemic, and antioxidant in streptozotocin-induced diabetic rats. Saudi Med J. 2013;34:727–33.

    PubMed  Google Scholar 

  31. Jensen CD, Spiller GA, Gates JE, Miller AF, Whittam JH. The effect of acacia gum and a water-soluble dietary fiber mixture on blood lipids in humans. J Am Coll Nutrit. 1993;12:147.

    CAS  Google Scholar 

  32. Kelley JJ, Tsai AC. Effect of pectin, gum Arabic and agar on cholesterol absorption, synthesis, and turnover in rats. J Nutr. 1978;108:630–9.

    CAS  PubMed  Google Scholar 

  33. Kurup TR, Wan LS, Chan LW. Interaction of preservatives with macromolecules: Part 1-natural hydrocolloids. Pharm Acta Helv. 1992;67:301.

    CAS  PubMed  Google Scholar 

  34. Lutz WK, Brändle E, Zbinden G. Effect of gum Arabic on aminopyrine demethylation in rats. Experientia. 1978;34:1609–10.

    CAS  PubMed  Google Scholar 

  35. Makkar A, Tewari S, Kishor K, et al. An unusual clinical presentation of plasma cell gingivitis related to “Acacia” containing herbal toothpaste. J Indian Soc Periodontol. 2013;17:527–30.

    PubMed  PubMed Central  Google Scholar 

  36. Matsumoto N, Riley S, Fraser D, et al. Butyrate modulates TGF-beta1 generation and function: potential renal benefit for Acacia (sen) SUPERGUM (gum Arabic)? Kidney Int. 2006;69:257–65.

    CAS  PubMed  Google Scholar 

  37. Mee KA, Gee DL. Apple fiber and gum Arabic lowers total and low-density lipoprotein cholesterol levels in men with mild hypercholesterolemia. J Am Diet Assoc. 1997;97:422–4.

    CAS  PubMed  Google Scholar 

  38. Nasir O, Artunc F, Saeed A, et al. Effects of gum Arabic (Acacia senegal) on water and electrolyte balance in healthy mice. J Ren Nutr. 2008;18:230–8.

    PubMed  Google Scholar 

  39. Nath D, Sethi N, Singh RK, Jain AK. Commonly used Indian abortifacient plants with special reference to their teratologic effects in rats. J Ethnopharmacol. 1992;36:147.

    CAS  PubMed  Google Scholar 

  40. Onishi T, Umemura S, Yanagawa M, et al. Remineralization effects of gum Arabic on caries-like enamel lesions. Arch Oral Biol. 2008;53:257–60.

    CAS  PubMed  Google Scholar 

  41. Patil RN, Patil RY, Ahirwar B, et al. Evaluation of antidiabetic and related actions of some Indian medicinal plants in diabetic rats. Asian Pac J Trop Med. 2011;4:20–3.

    PubMed  Google Scholar 

  42. Phillips GO. Acacia gum (Gum Arabic): a nutritional fibre; metabolism and calorific value. Food Addit Contam. 1998;15:251–64.

    CAS  PubMed  Google Scholar 

  43. Pradeep AR, Agarwal E, Bajaj P, et al. Clinical and microbiologic effects of commercially available gel and powder containing Acacia arabica on gingivitis. Aust Dent J. 2012;57:312–8.

    CAS  PubMed  Google Scholar 

  44. Pradeep AR, Happy D, Garg G. Short-term clinical effects of commercially available gel containing Acacia arabica: a randomized controlled clinical trial. Aust Dent J. 2010;55:65–9.

    CAS  PubMed  Google Scholar 

  45. Rehman KU, Codipilly CN, Wapnir RA. Modulation of small intestinal nitric oxide synthase by gum Arabic. Exp Biol Med (Maywood). 2004;229:895–901.

    CAS  Google Scholar 

  46. Ross AH, Eastwood MA, Brydon WG, et al. A study of the effects of dietary gum Arabic in humans. Am J Clin Nutr. 1983;37:368–75.

    CAS  PubMed  Google Scholar 

  47. Sander I, Raulf-Heimsoth M, Wiemer K, et al. Sensitization due to gum Arabic (Acacia senegal): the cause of occupational allergic asthma or cross reaction to carbohydrates? Int Arch Allergy Immunol. 2006;141:51–6.

    CAS  PubMed  Google Scholar 

  48. Schmitt D, Tran N, Riefler S, et al. Toxicologic evaluation of modified gum acacia: mutagenicity, acute and subchronic toxicity. Food Chem Toxicol. 2008;46:1048–54.

    CAS  PubMed  Google Scholar 

  49. Sethi N, Nath D, Singh RK. Teratological evaluation of some commonly used indigenous antifertility plants in rats. Int J Crude Drug Res. 1989;27:118.

    Google Scholar 

  50. Tambekar DH, Khante BS, Chandak BR, et al. Screening of antibacterial potentials of some medicinal plants from Melghat forest in India. Afr J Tradit Complement Altern Med. 2009;6:228–32.

    CAS  PubMed  PubMed Central  Google Scholar 

  51. Tangade PS, Mathur A, Tirth A, et al. Antigingivitis effects of Acacia arabica-containing toothpaste. Chin J Dent Res. 2012;15:49–53.

    PubMed  Google Scholar 

  52. Teichberg S, Wingertzahn MA, Moyse J, et al. Effect of gum Arabic in an oral rehydration solution on recovery from diarrhea in rats. J Pediatr Gastroenterol Nutr. 1999;29:411–7.

    CAS  PubMed  Google Scholar 

  53. Tsai AC, Elias J, Kelley JJ, et al. Influence of certain dietary fibers on serum and tissue cholesterol levels in rats. J Nutr. 1976;106:118–23.

    CAS  PubMed  Google Scholar 

  54. Turvill JL, Wapnir RA, Wingertzahn MA, et al. Cholera toxin-induced secretion in rats is reduced by a soluble fiber, gum Arabic. Dig Dis Sci. 2000;45:946–51.

    CAS  PubMed  Google Scholar 

  55. Wadood A, Wadood N, Shah SA. Effects of Acacia arabica and Caralluma edulis on blood glucose levels of normal and alloxan diabetic rabbits. J Pakistan Med Assoc. 1989;39:208.

    CAS  Google Scholar 

  56. Wapnir RA, Wingertzahn MA, Moyse J, Teichberg S. Gum Arabic promotes rat jejunal sodium and water absorption from oral rehydration solutions in two models of diarrhea. Gastroenterology. 1997;112:1979–85.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shahid Akbar .

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Akbar, S. (2020). Acacia nilotica (L.) Delile. (Fabaceae/Leguminosae). In: Handbook of 200 Medicinal Plants. Springer, Cham. https://doi.org/10.1007/978-3-030-16807-0_6

Download citation

Publish with us

Policies and ethics