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Acupuncture Treatment for Pain: Clinical and Laboratory Research

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Translational Acupuncture Research

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Abstract

Pain is a complex feeling with emotional driving and vegetative nerve reactions, and is one of the most common symptoms in the clinic. Pain has dual meanings to the human body. On the one hand, pain serves as a warning sign of injury, disease, and abnormality. A person with a loss of congenital pain cannot quickly respond to internal and external insults that often cause trauma, scald, or other injury. Those that have no pain or are insensitive to pain cannot respond to visceral disorders in time, which delays or misleads the diagnosis and treatment. On the other hand, persistent or severe pain brings suffering to the patient, and needs to be treated. However, many issues remain unsolved in term of pain management, e.g., analgesics-induced drug addiction. An abundance of research has shown that acupuncture or electroacupuncture can induce a good analgesic effect with little side effects. This chapter will summarize clinical and laboratory research on this topic and update recent progress.

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Abbreviations

5 Hydroxytryptamine:

5-HT

Acetylcholine:

ACh

Acetylcholinesterase:

AChE

AMP-activated protein kinase:

AMPK

Bio-breeding Zucker/Worcester:

BBZDR/Wor

Blood brain barrier:

BBB

Brain -derived neurotrophic factor:

BDNF

Catecholamine :

CA

Central Nervous System:

CNS

Choline acetyltransferase:

ChAT

Chronic compression injur:

CCI

Chronic low back pain:

cLBP

Chronic pelvic pain syndrome:

CPPS

Chronic prostatitis:

CP

Complete Freund’s adjuvant:

CFA

Delta-opioid receptors:

DOR

Diabetic painful neuropath:

DPN

Dopamine :

DA

Dorsal root ganglion:

DRG

Facial expression scoring:

FPS

Gamma-aminobutyric acid:

GABA

Goto-Kakizaki:

GK

κ-opioid receptors:

KOR

Irritable bowel syndrome:

IBS

Long-needle acupuncture :

LA

Lumbar disc herniation-induced:

LDH

Manual acupuncture :

MA

McGill pain questionaire:

MPQ

Monoamine oxidase:

MAO

Motor nerve conduction velocity:

MNCV

Mu- opioid receptors:

MOR

Neuropathic pain:

NP

Norepinephrine:

NE

Nuclei raphe magnus:

NRM

Numeric rating scale:

NRS

Painful diabetic neuropathy:

PDN

Partial sciatic nerve injury:

PNI

Periaqueductal grey:

PAG

Postdural puncture headache:

PDPH

Postherpetic neuralgia:

PHN

Postoperative nausea and vomiting:

PONV

Preproenkephalin:

PPE

Prodynorphin:

PDYN

Randomized controlled trials:

RCTs

Raphe-spinal:

R-S

Rostral ventromedial medulla:

RVM

Spinal cord dorsal horn:

SCDH

Spina cord injury:

SCI

Spinal manipulative therapy:

SMT

Spinal nerve ligation:

SNL

State-Trait Anxiety Inventory-State:

STAI-S

Streptozotocin:

STZ

Submedius:

SM

Substance P:

SP

The quality of life:

QOL

Total intravenous anesthesia:

TIVA

Traditional acupuncture :

TA

Trigger point acupuncture :

TrP

Transcutanclus Electrical Acupoint Stimulation:

TEAS

Transcutaneous electrical nerve stimulatior:

TENS

Vascular endothelial growth factor:

VEGF

Ventrolateral orbitalcortex:

VLO

Vesicular acetylcholine transporter:

VAChT

Verbal rating scale:

VRS

Visual analogue scale:

VAS

Zucker diabetic fatty:

ZDF

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Acknowledgements

Ying Xia is supported by the National Natural Science Foundation of China (#81873361), Science and Technology Commission of Shanghai Municipality (#18401970100, #15441903800) and Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function (14DZ2260500).

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Authors and Affiliations

  1. Department of Neurology, The People’s Hospital of the Hainan Province, Haikou, China

    Ting Wang, Zhiyan Sui & Guoqiang Wen

  2. The University of Connecticut, Storrs, CT, USA

    Terry C. Xia

  3. Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Fudan University, Shanghai, China

    Ying Xia

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    Ying Xia

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Wang, T., Sui, Z., Xia, T.C., Wen, G., Xia, Y. (2019). Acupuncture Treatment for Pain: Clinical and Laboratory Research. In: Xia, Y. (eds) Translational Acupuncture Research. Springer, Cham. https://doi.org/10.1007/978-3-030-16089-0_6

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