Abstract
Estrogen plays a key role in the development of breast cancer, and its blockage is the basis of hormone therapy.
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Brufsky A, Bosseman LD, Coradonna R, Haley BB, Jones CM, Moore HC, et al. Zoledronic acid effectively prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozol: Z-FAST Study 36-month follow-up results. Clin Breast Cancer. 2009;9(2):77–85. Patients receiving adjuvant letrozole were randomized (301 in each group) to receive zoledronic acid early or late. After 12 months, bone densitometry showed a 4.4% higher lumbar spine density and, in the hip, 3.3% higher in the early treatment group. Early use of zoledronic acid prevents loss of bone mass in postmenopausal women using adjuvant letrozole.
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Shimada, A.K., Alessi, J.V.M., Zucchetti, B., Katz, A. (2019). Adjuvant Hormone Therapy for Breast Cancer. In: Novita, G., Frasson, A., Millen, E., Zerwes, F., Cavalcante, F. (eds) Breast Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-13636-9_58
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DOI: https://doi.org/10.1007/978-3-030-13636-9_58
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