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Calcium Signaling pp 649–679Cite as

Regulation of Multifunctional Calcium/Calmodulin Stimulated Protein Kinases by Molecular Targeting

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1131))

Abstract

Multifunctional calcium/calmodulin-stimulated protein kinases control a broad range of cellular functions in a multitude of cell types. This family of kinases contain several structural similarities and all are regulated by phosphorylation, which either activates, inhibits or modulates their kinase activity. As these protein kinases are widely or ubiquitously expressed, and yet regulate a broad range of different cellular functions, additional levels of regulation exist that control these cell-specific functions. Of particular importance for this specificity of function for multifunctional kinases is the expression of specific binding proteins that mediate molecular targeting. These molecular targeting mechanisms allow pools of kinase in different cells, or parts of a cell, to respond differently to activation and produce different functional outcomes.

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Abbreviations

α-KAP:

αCaMKII anchoring protein

AMPK:

AMP-activated protein kinase

ATP:

Adenosine triphosphate

Ca2+ :

Calcium ions

CaM:

Calmodulin

CaMK:

Calcium/calmodulin stimulated protein kinases

CaMKI:

Calcium/calmodulin stimulated protein kinase I

CaMKII:

Calcium/calmodulin stimulated protein kinase II

CaMKIV:

Calcium/calmodulin stimulated protein kinase IV

CaMKK:

Calcium/calmodulin stimulated protein kinase kinase

CK1:

Casein kinase 1

CLK2:

CDC-like kinase 2

GSK-3:

Glycogen synthase kinase 3

PKA:

cAMP-dependent protein kinase

PKB:

Protein kinase B; Akt

PSD:

Post-synaptic density

S:

Serine

T:

Threonine

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  1. Priority Research Centre for Cancer Research, Innovation and Translation, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW, Australia

    Kathryn Anne Skelding

  2. Hunter Medical Research Institute, New Lambton Heights, NSW, Australia

    Kathryn Anne Skelding & John A. P. Rostas

  3. Priority Research Centre for Brain and Mental Health, and Priority Research Centre for Stroke and Brain Injury, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW, Australia

    John A. P. Rostas

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    Md. Shahidul Islam

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Skelding, K.A., Rostas, J.A.P. (2020). Regulation of Multifunctional Calcium/Calmodulin Stimulated Protein Kinases by Molecular Targeting. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 1131. Springer, Cham. https://doi.org/10.1007/978-3-030-12457-1_26

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