Abstract
Mycosis fungoides (MF) is the most common type of skin lymphoma and classically demonstrates a CD4-positive phenotype. However, a subset of MF cases is CD8-positive. Some aggressive lymphomas are CD8-positive and must be differentiated from indolent processes, such as lymphomatoid papulosis type D.
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Berti E, Tomasini D, Vermeer MH, et al. Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas. A distinct clinicopathological entity with an aggressive clinical behavior. Am J Pathol. 1999;155:483–92.
Petrella T, Maubec E, Cornillet-Lefebvre P, et al. Indolent CD8-positive lymphoid proliferation of the ear. A distinct primary cutaneous T-cell lymphoma. Am J Surg Pathol. 2007;31:1887–92.
Saggini A, Gulia A, Argenyi Z, et al. A variant of lymphomatoid papulosis simulating primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma. Description of 9 cases. Am J Surg Pathol. 2010 Aug;34(8):1168–75.
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Subtil, A. (2019). CD8-Positive Cutaneous Infiltrates. In: Diagnosis of Cutaneous Lymphoid Infiltrates. Springer, Cham. https://doi.org/10.1007/978-3-030-11654-5_16
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DOI: https://doi.org/10.1007/978-3-030-11654-5_16
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