Abstract
Fungal infections of the central nervous system (CNS) are widely observed in healthy hosts (Cryptococcus, Coccidioides, Histoplasma, Blastomyces, and Sporothrix) or in immunocompromised hosts by opportunistic pathogens (Candida, Aspergillus, Zygomycetes, and Trichosporon) (Redmond et al. 2007). Chronic meningitis or meningoencephalitis syndrome, brain abscess, rhino-cerebral syndrome, and rare fungal ventriculitis are among the clinical syndromes of CNS fungal infections and are frequently observed among children in clinical practice. CNS fungal infections should be considered in patients who have serous nasal flow, orbital pain, seizures, increased intracranial pressure, and meningitis with or without chronic febrile encephalitis. Initial characteristics of these CNS fungal infections are usually non-specific symptoms such as general fatigue, chronic fever, headache, subacute dementia, episodes, and neurologic deficits (Teive et al. 2008). Increased intracranial pressure (ICP) is responsible for both early mortality and auditory, visual, and cognitive symptoms of meningitis caused by fungal infections (Sun et al. 2004).
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Abbreviations
- CNS:
-
Central nervous system
- CSF:
-
Cerebrospinal fluid
- EVD:
-
Extraventricular drainage
- ICP:
-
Intracranial pressure
- ONS:
-
Optic nerve sheath
- PI:
-
Pulsatility index
- VA:
-
Ventriculoatrial
- VP:
-
Ventriculoperitoneal
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Aydın, H.E., Kaya, I. (2019). Raised Intracranial Pressure. In: Turgut, M., Challa, S., Akhaddar, A. (eds) Fungal Infections of the Central Nervous System. Springer, Cham. https://doi.org/10.1007/978-3-030-06088-6_18
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