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Uses and Regulatory Guidelines for Nutraceuticals in China

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Nutraceuticals in Veterinary Medicine

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Abstract

In China, nutraceuticals are not regulated as veterinary drugs but are approved as feed additives, feed premix, or feed. The use of additives in animal feed is supervised by the Ministry of Agriculture, which is responsible in evaluating, regulating, and publishing a catalog of feed additives, with advised dosing and limitations. However, detailed information is usually available in the product insert from the related company. Nutraceuticals traditionally include amino acids, vitamins, minerals, enzymes, live microorganism, antioxidants, and others. Herbal medicine additives are popular and therefore frequently used in animal feed. Among them are garlic, tea polyphenol, the extract of Eucommia ulmoides leaves, the extract of Epimedium, and the extract of Perilla seed. Additives are largely applied in intensive farming by a nutritionist, without the need of a prescription from a veterinarian. However, more veterinarians are increasingly prescribing nutraceuticals for pets. In this chapter, we will discuss the classification and regulatory rules of commonly used nutraceuticals approved in China for a better understanding of the regulatory provisions and rational application scenarios.

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References

  • Abu El Hammed W, Soufy H, El-Shemy A et al (2016) Use of allicin as feed additive to enhance vaccination capacity of Clostridium perfringens toxoid in rabbits. Vaccine 34(17):2000–2007

    Article  CAS  Google Scholar 

  • Alhashim M, Lombardo J (2018) Mechanism of action of topical garlic on wound healing. Dermatol Surg 44(5):630–634

    CAS  PubMed  Google Scholar 

  • American Veterinary Medical Association (1999) Guidelines for alternative and complementary veterinary medicine. In: AVMA directory and resource manual (48th edn). American Veterinary Medical Association, Schaumburg, IL

    Google Scholar 

  • Bag A, Bag N (2018) Tea polyphenols and prevention of epigenetic aberrations in cancer. J Nat Sci Biol Med 9(1):2–5

    Article  CAS  Google Scholar 

  • Chu XH, Hu JP, Wang ZG et al (2011) Effect of feeding of perilla seed extracts on growing finishing pigs. Acta Agric Zhejiang 23(3):514–516

    Google Scholar 

  • Demeule M, Brossard M, Turcotte S et al (2004) Diallyl disulfide, a chemopreventive agent in garlic, induces multidrug resistance-associated protein 2 expression. Biochem Biophys Res Commun 324(2):937–945

    Article  CAS  Google Scholar 

  • Deyama T, Nishibe S, Nakazawa Y (2001) Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacol Sin 22(12):1057–1070

    CAS  PubMed  Google Scholar 

  • Dubey H, Singh A, Patole AM et al (2017) Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats. Int Med Res 6(1):60–65

    Article  Google Scholar 

  • Eirna-liza N, Saad CR, Hassim HA, et al (2016). The effects of dietary inclusion of garlic on growth performance and disease resistance of African catfish (Clarias gariepinus) fingerlings against Aeromonas hydrophila infection. J Environ Biol 37(4 Spec No):817–824

    Google Scholar 

  • Geng Z, Rong Y, Lau BH (1997) S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Free Radic Biol Med 23(2):345–350

    Article  CAS  Google Scholar 

  • Gonen A, Harats D, Rabinkov A et al (2005) The antiatherogenic effect of allicin: possible mode of action. Pathobiology 72(6):325–334

    Article  CAS  Google Scholar 

  • Guerry-Force ML, Coggeshall J, Snapper J et al (1988) Morphology of noncardiogenic pulmonary edema induced by Perilla ketone in sheep. Am J Pathol 133(2):285–297

    CAS  PubMed  PubMed Central  Google Scholar 

  • Gupta RC (ed) (2016) Nutraceuticals: efficacy, safety and toxicity. Academic Press/Elsevier, Amsterdam, 1022 p

    Google Scholar 

  • Gupta RC, Srivastava A, Lall R (2018) Toxicity potential of nutraceuticals. In: Nicolotti O (ed) Computational toxicology: methods and protocols. Springer Nature, New York, NY, pp 367–394

    Chapter  Google Scholar 

  • Hirata T, Kobayashi T, Wada A et al (2011) Anti-obesity compounds in green leaves of Eucommia ulmoides. Bioorg Med Chem Lett 21(6):1786–1791

    Article  CAS  Google Scholar 

  • Hosoo S, Koyama M, Watanabe A et al (2017) Preventive effect of Eucommia leaf extract on aortic media hypertrophy in Wistar-Kyoto rats fed a high-fat diet. Hypertens Res 40(6):546–551

    Article  CAS  Google Scholar 

  • Huang J, Zhang Y, Zhou Y et al (2013) Green tea polyphenols alleviate obesity in broiler chickens through the regulation of lipid-metabolism-related genes and transcription factor expression. J Agric Food Chem 61(36):8565–8572

    Article  CAS  Google Scholar 

  • Jimoh AA, Ibitoye EB, Dabai YU et al (2013) In vivo antimicrobial potentials of garlic against Clostridium perfringens and its promotant effects on performance of broiler chickens. Pak J Biol Sci 16(24):1978–1984

    Article  CAS  Google Scholar 

  • Kaschula CH, Hunter R, Cotton J et al (2016) The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells. Mol Carcinog 55(8):1213–1228

    Article  CAS  Google Scholar 

  • Kitaji H, Ookutsu S, Sato M et al (2015) Preincubation with green tea polyphenol extract is beneficial for attenuating sperm injury caused by freezing-thawing in swine. Anim Sci J 86(11):922–928

    Article  CAS  Google Scholar 

  • Lee SD, Kim HY, Song YM et al (2009) The effect of Eucommia ulmoides leaf supplementation on the growth performance, blood and meat quality parameters in growing and finishing pigs. Anim Sci J 80(1):41–45

    Article  CAS  Google Scholar 

  • Li X, Tang Z, Fei D et al (2017) Evaluation of the sedative and hypnotic effects of astragalin isolated from Eucommia ulmoides leaves in mice. Nat Prod Res 31(17):2072–2076

    Article  CAS  Google Scholar 

  • Lin XL, Hu HJ, Liu YB et al (2017) Allicin induces the upregulation of ABCA1 expression via PPARγ/LXRα signaling in THP-1 macrophage-derived foam cells. Int J Mol Med 39(6):1452–1460

    Article  CAS  Google Scholar 

  • Lou Z, Wei QQ, Wang DW et al (2018) Effect of allicin on proliferation and apoptosis of KG-1 cells and its molecular mechanism. Zhongguo Zhong Yao Za Zhi 43(12):2612–2617

    PubMed  Google Scholar 

  • Mao X, Gu C, Chen D et al (2017) Oxidative stress-induced diseases and tea polyphenols. Oncotarget 8(46):81649–81661

    Article  Google Scholar 

  • Martins N, Petropoulos S, Ferreira IC (2016) Chemical composition and bioactive compounds of garlic (Allium sativum L.) as affected by pre- and post-harvest conditions: a review. Food Chem 211:41–50

    Article  CAS  Google Scholar 

  • Müller-Waldeck F, Sitzmann J, Schnitzler WH et al (2010) Determination of toxic perilla ketone, secondary plant metabolites and antioxidative capacity in five Perilla frutescens L. varieties. Food Chem Toxicol 48(1):264–270

    Article  Google Scholar 

  • Posadino AM, Phu HT, Cossu A et al (2017) Oxidative stress-induced Akt downregulation mediates green tea toxicity towards prostate cancer cells. Toxicol in Vitro 42:255–262

    Article  CAS  Google Scholar 

  • Rahman SU, Huang Y, Zhu L et al (2018) Therapeutic role of green tea polyphenols in improving fertility: a review. Nutrients 10(7):E834

    Article  Google Scholar 

  • Sarris J, Murphy J, Mischoulon D et al (2016) Adjunctive nutraceuticals for depression: a systematic review and meta-analyses. Am J Psychiatry 173(6):575–587

    Article  Google Scholar 

  • Senavong P, Kongkham S, Saelim S et al (2016) Neuroprotective effect of perilla extracts on PC12 cells. J Med Assoc Thail 99(Suppl 4):S256–S264

    Google Scholar 

  • Sheppard JG, McAleer JP, Saralkar P et al (2018) Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus. Eur J Med Chem 143:1185–1195

    Article  CAS  Google Scholar 

  • Shi YL, Gu XH, Huang Y et al (2015) Effect of perilla frutescens seed extracts on performance, reproductive hormone and immune function of laying hens during the late laying peak period. Chin J Anim Nutr 27(5):1519–1526

    Google Scholar 

  • The Ministry of Agriculture of the People’s Republic of China (1999) The approved feed additives. Notice No.105. http://jiuban.moa.gov.cn/zwllm/tzgg/gg/200210/t20021016_14634.htm

  • The Ministry of Agriculture of the People’s Republic of China (2003) The approved feed additive. Notice No.318. https://wenku.baidu.com/view/93dd81d533d4b14e85246859.html

  • The Ministry of Agriculture of the People’s Republic of China (2006) The approved feed additive. Notice No.658. http://www.moa.gov.cn/govpublic/XMYS/201006/t20100606_1535045.htm

  • The Ministry of Agriculture of the People’s Republic of China (2008) Feed additive catalog. Notice No.1126. http://www.moa.gov.cn/gk/tzgg_1/gg/201006/t20100606_1535108.htm

  • The Ministry of Agriculture of the People’s Republic of China (2009) Specification for safe use of feed additives. Notice No.1224. http://www.moa.gov.cn/govpublic/XMYS/201006/t20100606_1535173.htm

  • The Ministry of Agriculture of the People’s Republic of China (2012a) Management measures for approval number of feed additive and additive premix feed products. Decree No.3 in 2012. http://jiuban.moa.gov.cn/zwllm/tzgg/bl/201205/t20120508_2619500.htm

  • The Ministry of Agriculture of the People’s Republic of China (2012b) Management measures for the license number of feed additives and feed additive premix. Decree No.5 in 2012. http://www.gov.cn/gongbao/content/2012/content_2218048.htm

  • The Ministry of Agriculture of the People’s Republic of China (2013a) The approved feed additives. Notice No.2045. http://jiuban.moa.gov.cn/zwllm/tzgg/gg/201401/t20140103_3730193.htm

  • The Ministry of Agriculture of the People’s Republic of China (2013b) The approved feed additives. Notice No.2045. http://www.moa.gov.cn/nybgb/2014/dyq/201712/t20171219_6104350.htm

  • The Ministry of Agriculture of the People’s Republic of China (2014) Measures for the registration and management of imported feed and feed additives. Decree No.2 in 2014. http://jiuban.moa.gov.cn/zwllm/tzgg/bl/201401/t20140120_3743426.htm

  • The Ministry of Agriculture of the People’s Republic of China (2017) Specification for safe use of feed additives. Notice No.2625. http://www.moa.gov.cn/nybgb/2018/201801/201801/t20180129_6135954.htm

  • The State Council of the People’s Republic of China (2011) Regulations for management of feed and feed additives. Decree No.609. http://www.gov.cn/flfg/2011-11/15/content_1993910.htm

  • Wang C, Li Y, Wang Y (1998) A review of pharmacological study on Epimedium grandiflorum Morr and its active constituents. Zhongguo Zhong Yao Za Zhi 23(3):183–185

    CAS  PubMed  Google Scholar 

  • Wang JZ, Gao HY, Wang KZ et al (2011) Effect of Epimedium extract on osteoprotegerin and RANKL mRNA expressions in glucocorticoid-induced femoral head necrosis in rats. Nan Fang Yi Ke Da Xue Xue Bao 31(10):1714–1717

    PubMed  Google Scholar 

  • Wang J, Liu M, Wu Y et al (2016) Medicinal herbs as a potential strategy to decrease methane production by rumen microbiota: a systematic evaluation with a focus on Perilla frutescens seed extract. Appl Microbiol Biotechnol 100(22):9757–9771

    Article  CAS  Google Scholar 

  • Williamson G (2017) The role of polyphenols in modern nutrition. Nutr Bull 42(3):226–235

    Article  CAS  Google Scholar 

  • Yuan JR, Wang CF, Song J et al (2016) Effect of Epimedii Herba alcohol extract on inhibition of lung tumor growth and immunomodulatory. Zhongguo Zhong Yao Za Zhi 41(1):112–117

    PubMed  Google Scholar 

  • Zhang WH, Dong GZ, Wu YX et al (2011) Effects of perilla seed extracts on performance and immune function of finishing cattle. Chin J Anim Nutr 23(3):473–479

    CAS  Google Scholar 

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Acknowledgment

The authors would like to thank Ziqiang Wang for his technical assistance in preparation of this chapter.

Author information

Authors and Affiliations

  1. Academy of Sciences, Shanghai Institute of Materia Medica, Center for Drug Safety Evaluation and Research, Pudong, Shanghai, P.R. China

    Jianhua Sun & Likun Gong

  2. Department of Veterinary Medicine, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang, P.R. China

    Zhongqi Jiang

  3. Amlan Trading (Shenzhen) Company, Ltd., Shenzhen, Guangdong, P.R. China

    Feng Wang

Authors
  1. Jianhua Sun
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  2. Zhongqi Jiang
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  3. Feng Wang
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  4. Likun Gong
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Corresponding author

Correspondence to Jianhua Sun .

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Editors and Affiliations

  1. Department of Toxicology, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

    Ramesh C. Gupta

  2. Vets Plus Inc., University of Wisconsin–Stout, Menonomie, WI, USA

    Ajay Srivastava

  3. Vets Plus Inc., Menomonie, WI, USA

    Rajiv Lall

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Sun, J., Jiang, Z., Wang, F., Gong, L. (2019). Uses and Regulatory Guidelines for Nutraceuticals in China. In: Gupta, R., Srivastava, A., Lall, R. (eds) Nutraceuticals in Veterinary Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-04624-8_60

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