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Prevention of Asthma and Allergic Diseases During Childhood

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Asthma, Allergic and Immunologic Diseases During Pregnancy

Abstract

Allergic diseases, including atopic dermatitis, food allergy, allergic rhinitis, and asthma, often begin in childhood. The atopic march refers to the development of allergic disease in a typical progressive order starting with atopic dermatitis, followed by food allergy, then allergic rhinoconjunctivitis, and, finally, asthma. Over the past 40 years, there has been an increased incidence of allergic disease with up to a third of newborns considered to be at risk. Strong family histories of allergic disease support a role for genetic predisposition; however the increase in incidence cannot be accounted for by intergenerational changes alone. Numerous environmental exposures, including maternal and infant diet, microbial colonization, and toxin exposures, have been investigated for possible association with the development of allergic disease. In this chapter, we will review the existing data on environmental factors that may influence the development of asthma and allergic diseases in predisposed children. These studies provide insight into the mechanism of atopy as well as highlight potential preventive measures during pregnancy and early childhood.

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Authors and Affiliations

  1. Division of Pediatric Allergy & Immunology, University of California, San Diego, Rady Children’s Hospital San Diego, San Diego, CA, USA

    Stephanie A. Leonard

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  1. Stephanie A. Leonard
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Correspondence to Stephanie A. Leonard .

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  1. Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, CA, USA

    Jennifer A. Namazy

  2. Department of Allergy, Kaiser Permanente Medical Center, San Diego, CA, USA

    Michael Schatz

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Leonard, S.A. (2019). Prevention of Asthma and Allergic Diseases During Childhood. In: Namazy, J., Schatz, M. (eds) Asthma, Allergic and Immunologic Diseases During Pregnancy. Springer, Cham. https://doi.org/10.1007/978-3-030-03395-8_13

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  • DOI: https://doi.org/10.1007/978-3-030-03395-8_13

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