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A Clinical Case of Fertility Preservation in an Adolescent with Hodgkin Lymphoma

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Textbook of Oncofertility Research and Practice

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Abstract

NT is a 15-year-old post-menarchal girl; she was complaining of cervical enlargement, a weight loss of 21 kg in 3 months, night sweats, and fever. Clinical examination of the patient found a 2 cm fixed painless and firm right lateral jugular lymphadenopathy. The left cervical lymphadenopathy biopsy revealed a scleronodular Hodgkin’s disease. The patient’s disease was staged IIBb with mediastinal bulky according to the Ann Arbor classification system.

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Author information

Authors and Affiliations

  1. FERTILLIA ART center of Clinique La Rose, Tunis, Tunisia

    Mohamed Khrouf

  2. ART center of Aziza Othmana Public Hospital, Tunis, Tunisia

    Marouen Braham

  3. Hopital Abderrahmane Mami, Tunis, Tunisia

    Selim Khrouf

  4. Hematology Department, Military Hospital of Tunis, Faculté de Médecine de Tunis, Tunis, Tunisia

    Fehmi Msaddak

Authors
  1. Mohamed Khrouf
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  2. Marouen Braham
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  3. Selim Khrouf
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  4. Fehmi Msaddak
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Northwestern University , Chicago, IL, USA

    Teresa K. Woodruff

  2. Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA

    Divya K. Shah

  3. Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA

    Wendy S. Vitek

Review Questions and Answers

Review Questions and Answers

  1. Q1.

    What are the most important factors for the evaluation of gonadotoxicity risk of chemotherapy?

  2. A1.

    Age, pre-existing ovarian reserve, chemotherapy agents, and additional therapies (radiation, surgery).

  3. Q2.

    What is the best cycle day to start ovarian stimulation for fertility preservation?

  4. A2.

    Ovarian stimulation can be started at any day of cycle with the exception of the periovulatory window. Delaying ovarian stimulation to the 1st day of cycle is not recommended.

  5. Q3.

    What are the alternatives to vaginal oocyte pickup in adolescents?

  6. A3.

    Peruretheral transvesical, abdominal, or laparoscopic oocyte pickup may be more acceptable than transvaginal oocyte aspiration in some adolescents.

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Khrouf, M., Braham, M., Khrouf, S., Msaddak, F. (2019). A Clinical Case of Fertility Preservation in an Adolescent with Hodgkin Lymphoma. In: Woodruff, T., Shah, D., Vitek, W. (eds) Textbook of Oncofertility Research and Practice. Springer, Cham. https://doi.org/10.1007/978-3-030-02868-8_59

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  • DOI: https://doi.org/10.1007/978-3-030-02868-8_59

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-02867-1

  • Online ISBN: 978-3-030-02868-8

  • eBook Packages: MedicineMedicine (R0)

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