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Case Presentation: Sperm Banking in Patient Diagnosed with Acute Myeloid Leukemia

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Textbook of Oncofertility Research and Practice

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Abstract

A 23-year-old man presented to a referring hospital emergency room with gradually worsening throat pain. He was febrile to 38.4°C and his exam was notable for very large, erythematous tonsils. His labs were notable for a white blood cell (WBC) count of 119.8 K/cu mm (3.50–10.80 K/cu mm) with 91% blasts, creatinine elevated to 1.63 mg/dL (0.70–1.30 mg/dL), and lactate dehydrogenase (LDH) of 1122 U/L (≤250 U/L). Computed tomography (CT) of the neck was remarkable for the enlargement of tonsils and lymph nodes with a narrowing of the nasopharyngeal airway. He was started empirically on cefepime and transferred to a tertiary care intensive care unit (ICU) due to concern for impending airway compromise in the setting of likely new acute leukemia. Upon arrival, his peripheral blood smear was notable for numerous circulating blasts with a high nuclear to cytoplasmic ratio, a moderate amount of basophilic cytoplasm, open chromatin, and prominent nucleoli suggestive of monoblastic differentiation. Flow cytometry confirmed an immunophenotype consistent with acute myeloid leukemia (AML).

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Author information

Authors and Affiliations

  1. Oregon Health & Science University, Knight Cancer Institute, Portland, OR, USA

    Adam S. DuVall & Brandon Hayes-Lattin

  2. Department of Urology, Oregon Health & Science University, Portland, OR, USA

    Jason C. Hedges

Authors
  1. Adam S. DuVall
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  2. Jason C. Hedges
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  3. Brandon Hayes-Lattin
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Corresponding author

Correspondence to Brandon Hayes-Lattin .

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Northwestern University , Chicago, IL, USA

    Teresa K. Woodruff

  2. Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA

    Divya K. Shah

  3. Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA

    Wendy S. Vitek

Review Questions and Answers

Review Questions and Answers

  1. Q1.

    What is NOT a barrier to preserving fertility for those with cancer requiring chemotherapy?

    1. (a)

      Providers taking the time during a busy period to go over the risks to fertility

    2. (b)

      Cost of fertility-preserving measures

    3. (c)

      Medical status of the patient

    4. (d)

      Importance of fertility preservation to patients

    5. (e)

      Available facilities for fertility preservation

  1. A1.

    (d)

  2. Q2.

    True or false? There have been reports of transferring leukemia through egg or sperm preservation.

  3. A2.

    False

  1. Q3.

    What percentage of patients remembers discussing the impact of fertility of therapy with his/her provider?

    1. (a)

      10%

    2. (b)

      25%

    3. (c)

      50%

    4. (d)

      65%

    5. (e)

      90%

  1. A3.

    (c)

  1. Q4.

    What is the best option for a male patient who has reached sexual maturity but is unable to provide semen and still wishes to preserve fertility?

    1. (a)

      Nothing

    2. (b)

      TESE

    3. (c)

      Sexual education

    4. (d)

      Only offering fertility treatment following therapy

  1. A4.

    (b)

  2. Q5.

    True or false? Men with leukemia have decreased sperm counts in comparison to their healthy peers and to those of similar age with chronic diseases making sperm backing successfully more challenging.

  3. A5.

    True

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DuVall, A.S., Hedges, J.C., Hayes-Lattin, B. (2019). Case Presentation: Sperm Banking in Patient Diagnosed with Acute Myeloid Leukemia. In: Woodruff, T., Shah, D., Vitek, W. (eds) Textbook of Oncofertility Research and Practice. Springer, Cham. https://doi.org/10.1007/978-3-030-02868-8_51

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  • DOI: https://doi.org/10.1007/978-3-030-02868-8_51

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-02867-1

  • Online ISBN: 978-3-030-02868-8

  • eBook Packages: MedicineMedicine (R0)

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