Abstract
Obesity is associated with a chronic low-grade inflammatory state. Inflammatory cytokines that are produced in adipose tissue during obesity are involved in the development of an insulin resistant state and they participate in the development of type 2 diabetes and other metabolic complications of obesity. In this chapter, we will describe the network of signaling proteins which are used by the inflammatory cytokines to decrease insulin signaling and action. We will discuss the possibility to inhibit this network as new avenues for the treatment of insulin resistance and other metabolic complications of obesity.
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Tanti, JF., Jager, J., Le Marchand-Brustel, Y. (2013). Impact of Proinflammatory Cytokines on Adipocyte Insulin Signaling. In: Bastard, JP., Fève, B. (eds) Physiology and Physiopathology of Adipose Tissue. Springer, Paris. https://doi.org/10.1007/978-2-8178-0343-2_21
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DOI: https://doi.org/10.1007/978-2-8178-0343-2_21
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