Abstrait
Depuis le début des années 1970, ľexistence ďune relation étroite entre le statut nutritionnel et les capacités de réponse inflammatoire et immunitaire (RII) à ľagression est admise. Les premiers travaux ont montré qu’une dénutrition protéino-énergétique, altérait significativement la réponse immunitaire, tant innée qu’acquise, augmentant ainsi le risque infectieux et le taux de mortalité des malades les plus dénutris. Plus récemment, il est également apparu que ľobésité interférait avec la RII. Ces relations et les principaux mécanismes qui y conduisent seront brièvement revus dans la première partie de ce chapitre, après un rappel des étapes clés de la RII.
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Références
Tosi MF (2005) Innate immune responses to infection. J Allergy Clin Immunol 116: 241–9
Korzenic JR, Podolsky DK (2006) Evolving knowledge and therapy of inflammatory bowel disease. Nat Rev Drug Discov 5: 197–209
Wehkamp J, Fellerman K, Herrlinger KR et al. (2005) Mechanisms of disease: defensins in gastrointestinal diseases. Nat Clin Pract Gastroenterol Hepatol 2: 406–15
Beisswenger C, Bals R (2005) Antimicrobial peptides in lung inflammation. Chem Immunol Allergy 86: 55–71
Kawai T, Akira S (2005) Pathogen recognition with Toll-like receptors. Curr Opin Immunol 17: 338–44
Strober W, Murray PJ, Kitani A, Watanabe T (2006) Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol 6: 9–20
Zingarelli B (2005) Nuclear factor-kappa B. Crit Care Med 33(12 Suppl): S414–6
Rossi M, Young JW (2005) Human dendritic cells: potent antigen-presenting cells at the crossroads of innate and adaptive immunity. J Immunol 175: 1373–81
Nathan C (2006) Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 6: 173–82
Beaudeux JL, Vasson MP (2005) Sources cellulaires des espèces réactives de ľoxygène. In: Lavoisier, Éditions Tec & Doc, Éditions Médicales internationales (ed) Radicaux libres et stress oxydant. Aspects biologiques et pathologiques. Editions Tec & Doc, Éditions Médicales internationales, Londres-Paris-New York, p 45–86
Barouki R, Morel Y, Garlatti M (2005) Radicaux libres, facteurs transcriptionnels et régulation des gènes. In: Lavoisier, Éditions Tec & Doc, Éditions Médicales internationales (ed) Radicaux libres et stress oxydant. Aspects biologiques et pathologiques. Éditions Tec & Doc, Éditions Médicales internationales, Londres-Paris-New York, p 245
Chang CI, Liao J, Kuo L (1998) Arginase modulates nitric oxide production in activated macrophages. Am J Physiol 274: H342–8
Secco DD, Paron JA, de Oliveira SH et al. (2003) Neutrophil migration in inflammation: nitric oxide inhibits rolling, adhesion and induces apoptosis. Nitric Oxide 9: 153–64
Kaufmann SHE, Schaible UE (2005) Antigen presentation and recognition in bacterial infections. Curr Opin Immunol 17: 79–87
Kidd P (2003) Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev 8: 223–46
Jiang H, Chess L (2004) An integrated view of suppressor T cell subsets in immunoregulation. J Clin Invest 114: 1198–208
Elenkov IJ, Chrousos GP (2002) Stress hormones, proinflammatory and anti-inflammatory cytokines, and immunity. Ann N Y Acad, Sci 966: 290–303
MacConmara M, Lederer JA (2005) B cells. Crit Care Med 33 (Suppl.): S514–6
Jiang H, Chess L (2006) Regulation of immune responses by T cells. J Eng J Med 354: 1166–76
Heasman SJ, Giles KM, Ward C et al. (2003) Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation. J Endocrinol 178: 29–36
Herold MJ, McPherson KG, Reichardt HM (2006) Glucocorticoids in T cell, apoptosis and function. Cell Mol Life Sci 63: 60–72
Januszkiewicz A, Essen P, McNurlan MA et al. (2001) A combined stress hormone infusion decreases in vivo protein synthesis in human T lymphocytes in healthy volunteers. Metabolism 50: 1308–14
Walrand S, Guillet C, Boirie Y, Vasson MP (2004) In vivo evidences that in insulin regulates human polymorphonuclear neutrophil functions. J Leukoc Biol 76: 1104–10
Walrand S, Guillet C, Gachon P et al. (2005) Insulin regulates protein synthesis rate in leukocytes from young and elderly healthy humans. Clin Nutr 24: 1089–98
Fantuzzi G (2005) Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115: 911–9
Caldefie-Chezet F, Guillot J, Vasson MP (2003) La leptine: hormone et cytokine impliquée dans la réponse à ľagression. Nutr Clin Metabol 17: 15–23
Waelput W, Brouckaert P, Broekaert D, Tavernier J (2006) A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response, an update. Curr Med Chem 13:465–75
De Rosa V, Procaccini C, La Cava A et al. (2006) Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J Clin Invest 116: 447–55
Wolf AM, Wolf D, Rumpold H et al. (2004) Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-IRA in human leukocytes. Biochem Biophys Res Commun 323: 630–5
Hattori Y, Hattori S, Kasai K (2006) Globular adiponectin activates nuclear factor-kappaB in vascular endothelial cells, which in turn induces expression of proinflammatory and adhesion molecule genes. Diabetes Care 29: 139–41
van der Lely AJ, Tschop M, Heiman ML, Ghigo E (2004) Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25: 426–57
Sanders VM (2006) Interdisciplinary research: noradrenergic regulation of adaptive immunity. Brain Behav Immun 20: 1–8
Cartwright M (2004) The metabolic response to stress: a case of complex nutrition support management. Crit Care Nurs Clin N Am 16: 467–87
Baracos VE (2003) Overview on metabolic adaptation to stress. In: Cynober L, Moore FA (ed) Nutrition and critical care. Nestle Nutrition Workshop Series Clinical and Performance Program. Netc Ltd, Vevey (Suisse), vol 8, p 1–13
Wolfe RR (1987) Carbohydrate metabolism in the critically ill patients. Crit Care Clin 3: 11–24
McCowen KC, Malhortra A, Bistrian BR (2001) Stress induced hyperglycemia. Crit Care Clin 17: 107–24
Finney SJ, Zekveld C, Elia A, Evans TW (2003) Glucose control and mortality in critically ill patients. JAMA 290: 2041–7
van den Berghe G, Wouters P, Weekers F et al. (2001) Intensive insulin therapy in critically ill patients. N Engl J Med 345: 1359–67
van den Berghe G, Wilmer A, Hermans G et al. (2006) Intensive insulin therapy in the medical ICU. N Engl J Med 354: 449–61
Wolfe RR (2005) Regulation of skeletal muscle protein metabolism in catabolic states. Curr Opin Clin Nutr Metab Care 8: 61–5
Lee JO, Herndon DN (2003) Modulation of the post burn hypermetabolic state. In: Cynober L, Moore FA (ed) Nutrition and critical care. Nestle Nutrition Workshop Series Clinical and Performance Program, Netc Ltd, Vevey (Suisse), vol 8, p 39
Jeschke MG, Klein D, Herndon DN (2004) Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann Surg 239: 553–60
Nitenberg G (2003) Nutritional support in sepsis and multiple organ failure. In: Cynober L, Moore FA (ed) Nutrition and critical care. Nestle Nutrition Workshop Series Clinical and Performance Program. Netc Ltd, Vevey (Suisse), vol 8, p 223–44
Savino W (2002) The thymus gland is a target in malnutrition. Eur J Clin Nutr 56 (Suppl 3): S46–9
Chandra RK (1996) Nutrition, immunity and infection: from basic knowledge of dietary manipulation of immune response to practical application of ameliorating suffering and improving survival. Proc Natl Acad Sci USA 93: 14304–7
Lesourd B (2004) Nutrition: a major factor influencing immunity in the elderly. J Nutr Health Aging 8: 28–37
Cunningham-Rundles S, McNeeley DF, Moon A (2005) Mechanisms of nutrient modulation of the immune response. J Allergy Clin Immunol 115: 1119–28
Bastard JP, Maachi M, Lagathu C et al. (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17: 4–12
Esposito K, Pontillo A, Di Palo C et al. (2003) Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 289: 1799–804
van Dielen FM, Buurman WA, Hadfoune M et al. (2004) Macrophage inhibitory factor, plasminogen activator, inhibitor-1, other acute phase proteins, and inflammatory mediators normalize as a result of weight loss in morbidly obese subjects treated with gastric restrictive surgery. J Clin Endocrinol Metab 89: 4062–8
Albers R, Antoine JM, Bourdet-Sicard R et al. (2005) Markers to measure immunomodulation in human nutrition intervention studies. Br J Nutr 94: 452–81
Newsholme P, Curi R, Pithon Curi TC et al. (1999) Glutamine metabolism by lymphocytes, macrophages, and neutrophils: its importance in health and disease. J Nutr Biochem 10: 316–24
Newsholme P, Procopio J, Lima MM et al. (2003) Glutamine and glutamate: their central role in cell metabolism and function. Cell Biochem Funct 21: 1–9
Potenza MA, Nacci C, Mitolo-Chieppa D (2001) Immunoregulatory effects of L-arginine and therapeutical implications. Curr Drug Targets Immune Endocr Metabol Disord 1: 67–77
Bronte V, Zanovello P (2005) Regulation of immune responses by L-arginine metabolism. Nat Rev Immunol 5: 641–54
Curis E, Nicolis I, Moinard C et al. (2005) Almost all about citrulline in mammals. Amino Acids 29: 177–205
Muhling J, Fuchs M, Campos M et al. (2004) Effects of ornithine on neutrophil (PMN) free amino acid and alpha-keto acid profiles and immune functions in vitro. Amino Acids 27: 313–9
Santangelo F (2003) Intracellular thiol concentration modulating inflammatory response: influence on the regulation of cell functions through cysteine prodrug approach. Curr Med Chem 10: 2599–610
Dawson H, Collins G, Pyle R et al. (2004) The immunoregulatory effects of homocysteine and its intermediates on T-lymphocyte function. Mech Ageing Dev 125: 107–10
Schroecksnadel K, Frick B, Wirleitner B et al. (2004) Moderate hyperhomocysteinemia and immune activation. Curr Pharm Biotechnol 5: 107–18
Calder PC (2006) Branched-chain amino acids and immunity. J Nutr 136 (1 Suppl): 288S–93S
Grimble GK, Westwood OM (2001) Nucleotides as immunomodulators in clinical nutrition. Curr Opin Clin Nutr Metab Care 4: 57–64
Jason J, Archibald LK, Nwanyanwu OC et al. (2002) Vitamin A levels and immunity in humans. Clin Diagn Lab Immunol 9: 616–21
Azaïs-Braesco V, Grolier P (2001) Vitamine A et caroténoïdes provitaminiques. In: Martin A, Azaïs-Braesco V, Besson JL et al. (eds) Apports Nutritionnels Conseillés pour la Population Française 3e édition. Éditions Tec & Doc, Paris, p 221
Aukrust P, Muller F, Ueland T et al. (2000) Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses. Eur J Clin Invest 30: 252–9
Faure H, Fayol V, Galabert C et al. (1999) Carotenoids 2: Diseases and supplementation studies. Ann Biol, Clin (Paris) 57: 273–82
Hughes DA (1999) Effects of carotenoids on human immune function. Proc Nutr Soc 58: 713–8
Watzl B, Bub A, Brandstetter BR, Rechkemmer G (1999) Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables Br J Nutr 82: 383–9
Walrand S, Farges MC, Dehaese O et al. (2005) In vivo and in vitro evidences that carotenoids could modulate the neutrophil respiratory burst during dietary minipulation. Eur J Nutr 44: 114–20
Moriguchi S, Muraga M (2000) Vitamin E and immunity. Vitam Horm 59: 305–36
Hsieh CC, Huang CJ, Lin BF (2006) Low and high levels of alpha-tocopherol exert opposite effects on IL-2 possibly through the modulation of PPAR-gamma, IkappaBalpha, and apoptotic pathway in activated splenocytes. Nutrition 22: 433–40
Meydani SN, Han SN, Wu D (2005) Vitamin E and immune response in the aged: molecular mechanisms and clinical implications. Immunol Rev 205: 269–84
Tauler P, Aguilo A, Gimeno I et al. (2003) Differential response of lymphocytes and neutrophils to high intensity physical activity and to vitamin C diet supplementation. Free Radic Res 37: 931–8
Bergman M, Salman H, Djaldetti M et al. (2004) In vitro immune response of human peripheral blood cells to vitamins C and E. J Nutr Biochem 15: 45–50
Hayes CE, Nashold FE, Spach KM, Pedersen LB (2003) The immunological functions of the vitamin D endocrine system. Cell Mol Biol 49: 277–300
Matsuzaki J, Tsuji T, Zhang Y et al. (2006) 1alpha, 25-Dihydroxyvitamin D3 downmodulates the functional differentiation of Th1 cytokine-conditioned bone marrow-derived dendritic cells beneficial for cytotoxic T lymphocyte generation. Cancer Sci 97: 139–47
Helming L, Bose J, Ehrchen J et al. (2005) 1alpha,25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation. Blood 106: 4351–8
Meydani SN, Ribaya-Mercado JD, Russell RM et al. (1991) Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults. Am J Clin Nutr 53: 1275–80
Huang YC, Chang HH, Huang SC et al. (2005) Plasma pyridoxal 5′-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill. Nutrition 21: 779–85
Courtemanche C, Elson-Schwab I, Mashiyama ST et al. (2004) Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. J Immunol 173: 3186–92
Tamura J, Kubota K, Murakami H et al. (1999) Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol 116: 28–32
Cousins RJ, Blanchard RK, Moore JB et al. (2003) Regulation of zinc metabolism and genomic outcomes. J Nutr 133(5 Suppl 1): 1521S–6S
Fraker PJ, King LE (2004) Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr 24: 277–98
Baum MK, Campa A, Lai S et al. (2003) Zinc status in human immunodeficiency virus type 1 infection and illicit drug use. Clin Infect Dis 37 (Suppl 2): S117–23
Ferencik M, Ebringer L (2003) Modulatory effects of selenium and zinc on the immune system. Folia Microbiol (Praha) 48: 417–26
Rayman MP (2000) The importance of selenium to human health. Lancet 356: 233–41
He SX, Wu B, Chang XM et al. (2004) Effects of selenium on peripheral blood mononuclear cell membrane fluidity, interleukin-2 production and interleukin-2 receptor expression in patients with chronic hepatitis. World J Gastroenterol 10: 3531–3
Jason J, Archibald LK, Nwanyanwu OC et al. (2001) The effects of iron deficiency on lymphocyte cytokine production and activation: preservation of hepatic iron but not at all cost. Clin Exp Immunol 126: 466–73
Ahluwalia N, Sun J, Krause D et al. (2004) Immune function is impaired in iron-deficient, homebound, older women. Am J Clin Nutr 79: 516–21
Walker EM Jr, Walker SM (2000) Effects of iron overload on the immune system. Ann Clin Lab Sci 30: 354–65
Yaqoob P (2003) Lipids and the immune response: from molecular mechanisms to clinical application. Curr Opin Clin Nutr Metab Care 6: 133–50
Wu D (2004) Modulation of immune and inflammatory responses by dietary lipids. Curr Opin Lipidol 15: 43–7
Kelley DS, Dougherthy RM, Branch LB et al. (1992) Concentration of dietary n−6 polyunsaturated fatty acids and human immune status. Clin Immunol Immunopathol 62: 240–4
Kelley DS (2001) Modulation of human immune and inflammatory responses by dietary fatty acids. Nutrition 17: 669–73
Kew S, Banerjee T, Minihane AM et al. (2003) Relation between the fatty acid composition of peripheral blood mononuclear cells and measures of immune cell function in healthy, free-living subjects aged 25–72 y. Am J Clin Nutr 77: 1278–86
Larbi A, Grenier A, Frisch F et al. (2005) Acute in vivo elevation of intravascular triacylglycerol lipolysis impairs peripheral T cell activation. Am J Clin Nutr 82: 949–56
Calder PC (2003) N−3 polyunsaturated fatty acids and inflammation: from molecular biology to clinic. Lipids 38: 343–52
Trebble TM, Wootton SA, Miles EA et al. (2003) Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation. Am J Clin Nutr 78: 376–82
Sperling RI, Benincaso AI, Knoell CT et al. (1993) Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. J Clin Invest 91: 651–60
Calder PC (2005) Polyunsaturated fatty acids and inflammation. Biochem Soc Trans 33 (Pt2): 423–7
Trebble T, Arden NK, Stroud MA et al. (2003) Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation. Br J Nutr 90: 405–12
Serhan CN, Hong S, Gronert K et al. (2002) Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med 196: 1025–37
Zhao G, Etherton TD, Martin KR et al. (2005) Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. Biochem Biophys Res Commun 336: 909–17
Switzer KC, McMurray DN, Chapkins RS (2004) Effects of dietary n−3 polyunsaturated fatty acids on T-cell membrane composition and function. Lipids 39: 1163–70
Horejsi V (2005) Lipid rafts and their roles in T-cell activation. Microbes Infect 7: 310–6
Kew S, Mesa MD, Tricon S et al. (2004) Effects of oil rich in eicosapentaenoic and docohexaenoic acids on immune cell composition and function in healthy humans. Am J Clin Nutr 79: 674–81
Miles EA, Banerjee T, Dooper MMBW et al. (2004) The influence of different combinations of γ-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. Br J Nutr 91: 893–903
Rees D, Miles EA, Banerjee T et al. (2006) Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older man. Am J Clin Nutr 83: 331–42
Hasselmann M, Reimund JM (2004) Lipids in the nutritional support of the critically ill patients. Curr Opin Crit Care 10: 449–55
Moussa M, LeBoucher J, Garcia V et al. (2000) In vivo effects of olive oil-based lipid emulsion on lymphocyte activation in rats. Clin Nutr 19: 49–54
Reimund JM, Scheer O, Muller CD et al. (2004) In vitro modulation of inflammatory cytokine production by three lipid emulsions with different fatty acid compositions. Clin Nutr 23: 1324–32
Reimund JM, Rahmi G, Escalin G et al. (2005) Efficacy and safety of an olive oil-based intravenous fat emulsion in adult patients on home parenteral nutrition. Aliment Pharmacol Ther 21: 445–54
O’Shea M, Bassaganya-Riera J, Mohede ICM (2004) Immunomodulary properties of conjugated linoleic acid. Am J Clin Nutr 79 (suppl): 1199S–206S
Song HJ, Grant I, Rotondo D et al. (2005) Effect of CLA supplementation on immune function in young healthy volunteers. Eur J Clin Nutr 59: 508–17
Wahle KWJ, Heys SD, Rotondo D (2004) Conjugated linoleic acids: are they beneficial or detrimental to health? Prog Lipid Res 43: 553–87
Ogawa H, Rafiee P, Fisher PJ et al. (2003) Butyrate modulates gene and protein expression in human endothelial cells. Biochem Biophys Res Commun 309: 512–9
Saemann MD, Bohmig GA, Osterreicher CH et al. (2000) Antiinflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production. FASEB J 14: 2380–2
Gilbert KM, Wahid R, Fecher NP et al. (2000) Potential clinical use of butyric acid derivatives to induce antigen-specific T cell inactivation. J Pharmacol Exp Ther 294: 1146–53
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Vasson, MP., Reimund, JM. (2007). Nutrition, immunité et inflammation. In: Traité de nutrition artificielle de l’adulte. Springer, Paris. https://doi.org/10.1007/978-2-287-33475-7_34
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DOI: https://doi.org/10.1007/978-2-287-33475-7_34
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