Abstract
Over the last two decades, the treatment of psychosis has advanced substantially; yet, despite all progress, the immense individual and societal burden associated with psychosis, particularly due to schizophrenia, has largely stayed the same. Retrospective studies on the often years-long prodrome of psychotic disorders have shown that the vast majority of patients develop, among others, cognitive, perceptive, negative, and affective symptoms as well as precursors of positive symptoms and a significant loss of functioning even during the early phase of illness. Further, a long duration of untreated psychosis (DUP; time between the onset of the first frank psychotic symptom and the first adequate treatment) and a long duration of untreated illness (time between the onset of the first prodromal symptom and the first adequate treatment), have both been linked to a more negative outcome. For these reasons, an indicated prevention strategy of psychotic disorders and their negative consequences before they set in is regarded as the most promising approach to the management of these disorders.
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Lambert, M., Naber, D. (2013). Current Topics. In: Lambert, M. (eds) Current Schizophrenia. Springer Healthcare, Heidelberg. https://doi.org/10.1007/978-1-908517-68-5_2
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