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Small Animal Models for the Study of Cancer in Bone

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Bone and Cancer

Part of the book series: Topics in Bone Biology ((TBB,volume 5))

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Abstract

Advanced cancers commonly result in metastasis to bone where interactions between the cancer cell and the bone microenvironment produce predominantly osteoblastic or osteolytic lesions. In humans bone metastasis is observed in 60–85% of advanced cancers from tissues as disparate as prostate, breast, kidney, and lung [9]. In animals, however, spontaneous bone metastases are uncommon and investigation of the patterns of bone metastasis mimicking human cancer dissemination is challenging. Experimental models of bone metastasis consist of injections of cancer cells or tissue orthotopically, intracardially, intravenously (via the tail vein), or directly intraosseously into immunocompromised hosts, mostly mice, and, rarely, other small mammals such as dogs and cats.

David J. DeGraff and Fayth L. Miles contributed equally to this work.

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Authors and Affiliations

  1. Vanderbilt University Medical Center, Medical Center North, Nashville, TN, USA

    David J. DeGraff

  2. Department of Biological Sciences, University of Delaware, Newark, DE, USA

    Fayth L. Miles & Robert A. Sikes

  3. Department of Orthopedics and Rehabilitation, Pennsylvania State University College of Medicine, Hershey, PA, USA

    Ronald R. Gomes

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DeGraff, D.J., Miles, F.L., Gomes, R.R., Sikes, R.A. (2010). Small Animal Models for the Study of Cancer in Bone. In: Bone and Cancer. Topics in Bone Biology, vol 5. Springer, London. https://doi.org/10.1007/978-1-84882-019-7_12

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