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Magnesium in the Central Nervous System

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New Perspectives in Magnesium Research

Abstract

It has been almost a century since a role for magnesium in the central nervous system (CNS) was first proposed. Despite intensive efforts, the subsequent 75 years saw few advances in our understanding of magnesium’s precise role in brain function or the mechanisms by which the cation infl uences these functions. More recently, the advent of noninvasive techniques to measure intracellular free magnesium concentration, plus the recognition that magnesium plays a critical role in regulating neurotransmitter receptor function, have ushered in a new era for magnesium research in neuroscience. The result has been thousands of published studies describing various effects of magnesium in the CNS, ranging from effects on normal physiology and biochemistry to modulation of pathological events at the molecular level. The current review critically examines the evidence suggesting that alterations in intracellular free magnesium concentration may be an injury factor in acute and chronic CNS injury, as well as the potential for magnesium administration to be neuroprotective under these conditions. Finally, the reasons for contradictory results in the literature regarding therapeutic efficacy are discussed, with an emphasis on cellular energy state and how it may affect treatment, as well as dosage strategies and the potential for adverse side effects.

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Authors and Affiliations

  1. Division of Pathology School of Medical Sciences, University of Adelaide, Adelaide, SA, Australia

    Renee J. Turner BSc

  2. Neurosurgical Research Division of Pathology, School of Medical Sciences University of Adelaide, Adelaide, SA, Australia

    Robert Vink PhD

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  1. Renee J. Turner BSc
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  2. Robert Vink PhD
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Editors and Affiliations

  1. Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan

    Yoshiki Nishizawa MD, PhD (Dean of Medicine, Professor of Internal Medicine) (Dean of Medicine, Professor of Internal Medicine)

  2. Osaka City University, Osaka, Japan

    Hirotoshi Morii MD, PhD (Emeritus Professor) (Emeritus Professor)

  3. Université Pierre et Marie Curie, Paris, France

    Jean Durlach MD, PhD (President of the International Society for the Development of Research on Magnesium (SDRM), Editor-in-Chief Magnesium Research journal) (President of the International Society for the Development of Research on Magnesium (SDRM), Editor-in-Chief Magnesium Research journal)

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© 2007 Springer-Verlag London Limited

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Turner, R.J., Vink, R. (2007). Magnesium in the Central Nervous System. In: Nishizawa, Y., Morii, H., Durlach, J. (eds) New Perspectives in Magnesium Research. Springer, London. https://doi.org/10.1007/978-1-84628-483-0_28

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  • DOI: https://doi.org/10.1007/978-1-84628-483-0_28

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-388-8

  • Online ISBN: 978-1-84628-483-0

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