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Lymph Node Dissection for Carcinoma of the Esophagus

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Difficult Decisions in Thoracic Surgery

Abstract

The controversy surrounding the surgical treatment of esophageal cancer focuses, almost exclusively, on the extent of lymph node dissection required during esophagectomy. The majority view holds that an extended or a radical lymph node dissection will not improve overall or disease-free survival because the disease is systemic at the time of diagnosis and that long-term outcomes are largely determined by the biological behavior of the tumor; an issue that cannot be influenced by the extent of surgical dissection. Advocates of this view embrace the conventional techniques of esophageal resection where the esophagus is extracted from its mediastinal bed along with the adjacent periesophageal and lesser curvature nodes. This extent of lymph node excision is easily achieved by either a transhiatal or a transthoracic approach and thus, the terms transhiatal or transthoracic are descriptive only of the means of surgical access rather than the extent of lymph node dissection which is, for all intents and purposes, similar in extent.

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References

  1. Orringer, MB, Marshall B, Iannettoni MD. Transhiatal esophagectomy: clinical experience and refinements. Ann Surg 1999;230:392–403.

    Article  PubMed  CAS  Google Scholar 

  2. Gelfand GA, Finley RJ, Nelems B, Inculet R, Evans KG, Fradet G. Transhiatal esophagectomy for carcinoma of the esophagus and cardia. Experience with 160 cases. Arch Surg 1992;127:164–167.

    Google Scholar 

  3. Gertsch P, Vauthey JN, Lustenberger AA, Friedlander-Klar H. Long-term results of transhiatal esophagectomy for esophageal carcinoma. A multivariate analysis of prognostic factors. Cancer 1993;72:2312–2319.

    Article  PubMed  CAS  Google Scholar 

  4. Vigneswaran WT, Trastek VF, Pairolero PC, Deschamps C, Daly RC, Allen MS. Transhiatal esophagectomy for carcinoma of the esophagus. Ann Thorac Surg 1993;56:838–844.

    Article  PubMed  CAS  Google Scholar 

  5. Chu KM, Law SY, Fok M, Wong J. A prospective randomized comparison of transhiatal and transthoracic resection for lower-third esophageal carcinoma. Am J Surg 1997;174:320–324.

    Article  PubMed  CAS  Google Scholar 

  6. Horstmann O, Verreet PR, Becker H, Ohmann C, Roher HD. Transhiatal oesophagectomy compared with transthoracic resection and systematic lymphadenectomy for the treatment of oesophageal cancer. Eur J Surg 1995;161:557–567.

    PubMed  CAS  Google Scholar 

  7. Goldminc M, Maddern G, Le Prise E, Meunier B, Campion JP, Launois B. Oesophagectomy by a transhiatal approach or thoracotomy: a prospective randomized trial. Br J Surg 1993;80:367–370.

    Article  PubMed  CAS  Google Scholar 

  8. Ellis FH Jr. Standard resection for cancer of the esophagus and cardia. Surg Oncol Clin N Am 1999;8:279–294.

    PubMed  Google Scholar 

  9. Visbal AL, Allen MS, Miller DL, Deschamps C, Trastek VF, Pairolero PC. Ivor Lewis esophagogastrectomy for esophageal cancer. Ann Thorac Surg 2001;71:1803–1808.

    Article  PubMed  CAS  Google Scholar 

  10. Putnam JB Jr, Suell DM, McMurtrey MJ, et al. Comparison of three techniques of esophagectomy within a residency training program. Ann Thorac Surg 1994;57:319–325.

    Article  PubMed  Google Scholar 

  11. Karl RC, Schreiber R, Boulware D, Baker S, Coppola D. Factors affecting morbidity, mortality, and survival in patients undergoing Ivor Lewis esophagogastrectomy. Ann Surg 2000;231:635–643.

    Article  PubMed  CAS  Google Scholar 

  12. Lieberman MD, Shriver CD, Bleckner S, Burt M. Carcinoma of the esophagus. Prognostic significance of histologic type. J Thorac Cardiovasc Surg 1995;109:130–138.

    Article  PubMed  CAS  Google Scholar 

  13. Wright CD, Mathisen DJ, Wain JC, et al. Evolution of treatment strategies for adenocarcinoma of the esophagus and gastroesophageal junction. Ann Thorac Surg 1994;58:1574–1578.

    Article  PubMed  CAS  Google Scholar 

  14. Sharpe DA, Moghissi K. Resectional surgery in carcinoma of the esophagus and cardia: What influences long-term survival? Eur J Cardiothorac Surg 1996;10:359.

    Article  PubMed  CAS  Google Scholar 

  15. Hofstetter W, Swisher SG, Correa AM, et al. Treatment outcomes of resected esophageal cancer. Ann Surg 2002;236:376–384.

    Article  PubMed  Google Scholar 

  16. Adam DJ, Craig SR, Sang CT, Walker WS, Cameron EW. Esophagogastrectomy for carcinoma in patients under 50 years of age. J R Coll Surg Obstet 1996;41:371–373.

    CAS  Google Scholar 

  17. Kelsen DP, Ginsberg R, Pajak TF, et al. Chemotherapy followed by surgery compared with surgery alone for localized e sophageal cancer. N Engl J Med 1998;339:1979–1984.

    Article  PubMed  CAS  Google Scholar 

  18. Walsh TN, Noonan N, Hollywood D, Kelly A, Keeling N, Hennessy TP. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med 1996;335:462–467.

    Article  PubMed  CAS  Google Scholar 

  19. Skinner DB. En-bloc resection for neoplasms of the esophagus and cardia. J Thorac Cardiovasc Surg 1983;85:59–69.

    PubMed  CAS  Google Scholar 

  20. Daly JM, Fry WA, Little AG, et al. Esophageal cancer: results of an American College of Surgeons Patient Care Evaluation Study. J Am Coll Surg 2000;190:562–572; discussion 572–573.

    Article  PubMed  CAS  Google Scholar 

  21. Urba SG, Orringer MB, Turrisi A, et al. Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol 2001;19:305–313.

    PubMed  CAS  Google Scholar 

  22. Barbier PA, Luder PJ, Schupfer G, Becker CD, Wagner HE. Quality of life and patterns of recurrence following transhiatal esophagectomy for cancer: results of a prospective follow-up in 50 patients. World J Surg 1988;12:270–276.

    Article  PubMed  CAS  Google Scholar 

  23. Hulscher JB, van Sandick JW, Tijssen JG, Obertop H, van Lanschot JJ. The recurrence pattern of esophageal carcinoma after transhiatal resection. J Am Coll Surg 2000;191:143–148.

    Article  PubMed  CAS  Google Scholar 

  24. Medical Research Council Oesophageal Cancer Working Party. Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomized controlled trial. Lancet 2002;359:1727–1733.

    Article  Google Scholar 

  25. Rindani R, Martin, CJ, Cox MR. Transhiatal versus Ivor-Lewis esophagectomy: is there a difference? Aust N Z J Surg 1999;69:187–194.

    Article  PubMed  CAS  Google Scholar 

  26. Hulscher JB, Tijssen JG, Obertop H, van Lanschot JJ. Transthoracic versus transhiatal resection for carcinoma of the esophagus: a meta-analysis. Ann Thorac Surg 2001;72:306–313.

    Article  PubMed  CAS  Google Scholar 

  27. Logan A. The surgical treatment of carcinoma of the esophagus and cardia. J Thorac Cardiovasc Surg 1963;46:150–161.

    PubMed  CAS  Google Scholar 

  28. Nigro JJ, De Meester SR, Hagen JA, et al. Node status in transmural esophageal adenocarcinoma and outcome after en-bloc esophagectomy. J Thorac Cardiovasc Surg 1999;117:960–968.

    Article  PubMed  CAS  Google Scholar 

  29. Altorki NK, Girardi L, Skinner DB. En-bloc esophagectomy improves survival for stage III esophageal cancer. J Thorac Cardiovasc Surg 1997;114:948–955.

    Article  PubMed  CAS  Google Scholar 

  30. Herskovic A, Martz K, Al-Sarraf M, et al. Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med 1992;326:1593–1598.

    Article  PubMed  CAS  Google Scholar 

  31. Lerut T, Moons J, Fieuws S. Extracapsular lymph node involvement in esophageal cancer and number of involved nodes. J Thorac Cardiovasc Surg 2004;127:1855–1856.

    Article  PubMed  CAS  Google Scholar 

  32. Altorki N, Skinner D. Should en bloc esophagectomy be the standard of care for esophageal carcinoma? Ann Surg 2001;234:581–587.

    Article  PubMed  CAS  Google Scholar 

  33. Hagen JA, Peters JH, De Meester TR. Superiority of extended en bloc esophagogastrectomy for carcinoma of the lower esophagus and cardia. J Thorac Cardiovasc Surg 1993;106:850–858.

    PubMed  CAS  Google Scholar 

  34. Hulscher JB, van Sandick JW, de Boer AG, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus. N Engl J Med 2002;347:1662–1669.

    Article  PubMed  Google Scholar 

  35. Hulscher JB, van Lanschot JJ. Individualised surgical treatment of patients with an adenocarcinoma of the distal oesophagus or gastro-oesophageal junction. Dig Surg 2005;22:130–134.

    Article  PubMed  CAS  Google Scholar 

  36. Isono K, Onada S, Okuyama K, et al. Recurrence of intrathoracic esophageal cancer. Jpn J Clin Oncol 1985;15:49–60.

    PubMed  CAS  Google Scholar 

  37. Isono K, Sato H, Nakayama K. Results of nationwide study of the three-field lymph node dissection of esophageal cancer. Oncology 1991;48:411–420.

    Article  PubMed  CAS  Google Scholar 

  38. Akiyama H, Tsurumaru M, Udagawa H, Kajiyama Y. Radical lymph node dissection for cancer of the thoracic esophagus. Ann Surg 1994;220:364–372.

    Article  PubMed  CAS  Google Scholar 

  39. Nishihira T, Hirayama K, Mori S. A prospective randomized trial of extended cervical and superior mediastinal lymphadenectomy for carcinoma of the thoracic esophagus. Am J Surg 1998;175:47–51.

    Article  PubMed  CAS  Google Scholar 

  40. Kato H, Watanabe H, Tachimori Y, Iizuka T. Evaluation of the neck lymph node dissection for thoracic esophageal carcinoma. Ann Thorac Surg 1991;51:931–935.

    Article  PubMed  CAS  Google Scholar 

  41. Altorki N, Kent M, Ferrara C, Port J. Three-field lymph node dissection for squamous cell and adenocarcinoma of the esophagus. Ann Surg 2002;236:177–183.

    Article  PubMed  Google Scholar 

  42. Lerut T, Nafteux P, Moons J, et al. Three-field lymphadenectomy for carcinoma of the esophagus and gastroesophageal junction in 174 R0 resections: impact on staging, disease-free survival, and outcome: a plea for adaptation of TNM classification in upper-half esophageal carcinoma. Ann Surg 2004;240:962–972.

    Article  PubMed  CAS  Google Scholar 

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Altorki, N.K. (2007). Lymph Node Dissection for Carcinoma of the Esophagus. In: Ferguson, M.K. (eds) Difficult Decisions in Thoracic Surgery. Springer, London. https://doi.org/10.1007/978-1-84628-474-8_27

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  • DOI: https://doi.org/10.1007/978-1-84628-474-8_27

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-384-0

  • Online ISBN: 978-1-84628-474-8

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