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Transurethral resection in patients with muscle-infiltrating bladder cancer

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Invasive Bladder Cancer

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Abstract

Radical cystectomy is the gold standard therapy for patients with invasive bladder cancer. However, in patients with locally advanced disease, survival is not completely satisfactory, promoting the development of combination therapies, and associating chemotherapy to cystectomy.1,2 In patients with low local stages, radical cystectomy can be an overtreatment, according to the literature, where the absence of residual tumour (p0) on cystectomy specimens is around 12%.3–6 This absence of residual tumour does not necessarily mean that patients are cured with cystectomy, however, as the five-year survival rate was 67% in Pagano’s series.4 This decrease in survival is essentially related to the development of distant metastasis due to the presence of micrometastasis at the time of cystectomy. Consequently, a p0 after cystectomy only means that the tumour was completely removed by transurethral resection (TUR) during the clinical assessment and patients were probably overtreated because cystectomy does not have any, or at least only minimal, impact on micrometastases.

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Authors and Affiliations

  1. Department of Urology, Instituto Valenciano de Oncología, Valencia, Spain

    Eduardo Solsona

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  1. Eduardo Solsona
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Editors and Affiliations

  1. Department of Urology, Catholic University Medical School, Rome, Italy

    PierFrancesco Bassi MD (Professor of Urology Chief and Chairman) (Professor of Urology Chief and Chairman)

  2. University of Padova Medical School, Padova, Italy

    Francesco Pagano MD (Professor of Urology) (Professor of Urology)

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© 2007 Springer-Verlag London Limited

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Solsona, E. (2007). Transurethral resection in patients with muscle-infiltrating bladder cancer. In: Bassi, P., Pagano, F. (eds) Invasive Bladder Cancer. Springer, London. https://doi.org/10.1007/978-1-84628-377-2_9

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  • DOI: https://doi.org/10.1007/978-1-84628-377-2_9

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-376-5

  • Online ISBN: 978-1-84628-377-2

  • eBook Packages: MedicineMedicine (R0)

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