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Evolving Genomics of Pulmonary Fibrosis

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Idiopathic Pulmonary Fibrosis

Part of the book series: Respiratory Medicine ((RM,volume 9))

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Abstract

Genomic-scale transcript profiling approaches provide an unbiased view of the transcriptome of organs, tissues, and cells. Such technologies have been applied to the study of lungs and cells of patients with fibrotic lung disease and animal models of lung disease with the goal of detecting key molecules that play a significant role in pathogenesis, identifying potential drug targets, and developing biomarkers of disease presence, progression, and outcome. Genomic profiling studies have also been used to classify and distinguish different interstitial lung diseases such as IPF, nonspecific interstitial pneumonia (NSIP), lung fibrosis associated with scleroderma, and hypersensitivity pneumonitis (HP). In this chapter, we describe the progress and insights derived from applying genomic-scale transcript profiling approaches to fibrotic lung diseases as well as the potential impact of new technologies and NIH-funded projects on the field of genomics.

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Authors and Affiliations

  1. Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA

    Jose D. Herazo-Maya M.D. & Naftali Kaminski M.D.

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  1. Jose D. Herazo-Maya M.D.
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  2. Naftali Kaminski M.D.
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  1. Dept. Internal Medicine, Sect. Allergy Pulmonary & Critical Care Med., University of Wisconsin School of Medicine & Public Health, Madison, Wisconsin, USA

    Keith C. Meyer

  2. Advanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia, USA

    Steven D. Nathan

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Herazo-Maya, J.D., Kaminski, N. (2014). Evolving Genomics of Pulmonary Fibrosis. In: Meyer, K., Nathan, S. (eds) Idiopathic Pulmonary Fibrosis. Respiratory Medicine, vol 9. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-682-5_19

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  • DOI: https://doi.org/10.1007/978-1-62703-682-5_19

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