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Histotripsy

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Imaging and Focal Therapy of Early Prostate Cancer

Part of the book series: Current Clinical Urology ((CCU))

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Abstract

Histotripsy is an experimental focused ultrasound technology that utilizes controlled cavitation (microbubbles) to mechanically homogenize targeted tissues. The bubble cloud produced is easily identifiable on ultrasound images and provides feedback and localization of mechanical ablation. The tissue homogenate is composed of acellular liquefied debris which facilitates drainage and resorption. A sharp treatment boundary is achievable in part due to the nonthermal mechanism of tissue effect. Preclinical studies support the localization of ablative effects and general safety of histotripsy, as well as demonstrate that the neurovascular bundle and urinary sphincter are resistant to structural damage. Analysis of the imaging data of the male human pelvis suggests that a perineal approach affords adequate acoustic aperture for prostate treatment. Histotripsy ablation of implanted tumors is feasible without apparent increased risk of inducing metastasis in initial preclinical studies. Histotripsy is a unique focused ultrasound ablative modality that has significant potential as a focal therapy for prostate cancer.

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Authors and Affiliations

  1. Department of Urology, University of Michigan, TC 3879, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-5330, USA

    William W. Roberts M.D.

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  1. William W. Roberts M.D.
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Correspondence to William W. Roberts M.D. .

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  1. , Department of Surgery, Duke Cancer Institute, Room 1089 Duke South, Durham, 27710, North Carolina, USA

    Thomas J. Polascik

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Roberts, W.W. (2013). Histotripsy. In: Polascik, T. (eds) Imaging and Focal Therapy of Early Prostate Cancer. Current Clinical Urology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-182-0_24

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  • DOI: https://doi.org/10.1007/978-1-62703-182-0_24

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-181-3

  • Online ISBN: 978-1-62703-182-0

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