Skip to main content
SpringerLink
Log in

Overview of the Microfluidic Diagnostics Commercial Landscape

  • Protocol
  • First Online:
Microfluidic Diagnostics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 949))

Abstract

Since its birth in the late 1980s, the field of microfluidics has continued to mature, with a growing number of companies pursuing diagnostic applications. In 2009 the worldwide in vitro diagnostics market was estimated at >$40 billion USD, and microfluidic diagnostics are poised to reap a significant part of this market across a range of areas including laboratory diagnostics, point-of-care diagnostics, cancer diagnostics, and others. The potential economic advantages of microfluidics are numerous and compelling: lower reagent and/or sample volumes, lower equipment costs, improved portability, increased automation, and increased measurement speed. All of these factors may help put more information in the hands of doctors and patients sooner, enabling earlier disease detection and more tailored, effective treatments. This chapter reviews the microfluidic diagnostics commercial landscape and discusses potential commercialization challenges and opportunities.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kalorama Information: In Vitro Diagnostics Market Doubled Over Decade: Kalorama Reports. http://www.kaloramainformation.com/about/release.asp?id=1771. Accessed 12 Nov 2012

  2. Sklar LA, Carter MB, Edwards BS (2007) Flow cytometry for drug discovery, receptor pharmacology and high throughput screening. Curr Opin Pharmacol 7:527–534

    Article  CAS  Google Scholar 

  3. Maheswaran S, Haber DA (2010) Circulating tumor cells: a window into cancer biology and metastasis. Curr Opin Genet Dev 20:96–99

    Article  CAS  Google Scholar 

  4. Home—ClinicalTrials.gov. http://clinicaltrials.gov/. Accessed 12 Nov 2012

  5. On-Q-ity: Diagnose, Monitor, Save. http://www.on-q-ity.com/publications/. Accessed 12 Nov 2012

  6. Nagrath S et al (2007) Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450:1235–1239

    Article  CAS  Google Scholar 

  7. Company Description—Biocept Website. http://www.biocept.com/. Accessed 12 Nov 2012

  8. Cytoscale Website. http://cytoscale.com/. Accessed 25 Oct 2010

  9. Superior NanoBioSystems—Home. http://www.superiornanobiosystems.com/index.html. Accessed 12 Nov 2012

  10. Near patient microfluidic rare cell detection: a paradigm shift in flow cytometry. http://www.cli-online.com/index.php?id=1024&tx_ttproducts_pi1(product)=2714&swords=near%20patient%20gerdes. Accessed 12 Nov 2012

    Google Scholar 

  11. Lancaster C et al (2005) Rare cancer cell analyzer for whole blood applications: microcytometer cell counting and sorting subcircuits. Methods 37:120–127

    Article  CAS  Google Scholar 

  12. Micronics Microfluidics: Lab Automation & Nanotechnology. http://www.micronics.net/technology. Accessed 12 Nov 2012

  13. Veridex, LLC, a Johnson & Johnson company in vitro diagnostics oncology. http://www.veridex.com/cellsearch/CellSearchHCP.aspx. Accessed 12 Nov 2012

  14. Sequist LV et al (2009) The CTC-chip: an exciting new tool to detect circulating tumor cells in lung cancer patients. J Thorac Oncol 4:281–283

    Article  Google Scholar 

  15. Veridex, LLC Announces Collaboration to Develop Next-Generation Circulating Tumor Cell (CTC) Technology with Massachusetts General Hospital. http://www.jnj.com/connect/news/all/veridex-llc-announces-collaboration-to-develop-next-generation-circulating-tumor-cell-technology-with-massachusetts-general-hospital. Accessed 12 Nov 2012

  16. Welcome to Artemis Health—Our mission is to develop tests that provide accurate and timely information about fetal and maternal health. http://www.verinata.com/. Accessed 12 Nov 2012

  17. StreetInsider.com—Canaccord Adams Raises Price Target On Inverness Medical (IMA) to $49, Citing Pima System. http://www.streetinsider.com/Analyst+Comments/Canaccord+Adams+Raises+Price+Target+On+Inverness+Medical+(IMA)+to+$49,+Citing+Pima+System/4974389.html. Accessed 12 Nov 2012

  18. Daktari Diagnostics, Inc. http://www.daktaridx.com/. Accessed 12 Nov 2012

  19. Daktari Diagnostics, Backed by Gates Foundation, Raises Funds for HIV Test Study | Xconomy. http://www.xconomy.com/boston/2010/06/17/daktari-diagnostics-backed-by-gates-foundation-raises-funds-for-hiv-test-study/. Accessed 12 Nov 2012

  20. University Funding and Grants | Scientific Frontline Communication Center. HIV treatment test closer to manufacture with new $7.3 million grant. http://www.sflorg.com/comm_center/unv_funding/. 12 Nov 2012

  21. Daktari Diagnostics, Backed by Gates Foundation, Raises Funds for HIV Test Study | Xconomy. http://www.xconomy.com/boston/2010/06/17/daktari-diagnostics-backed-by-gates-foundation-raises-funds-for-hiv-test-study/. Accessed 12 Nov 2012

  22. PIMA: Home. http://pimatest.com/en/home.html. Accessed 12 Nov 2012

  23. Mtapuri-Zinyowera S et al (2010) Evaluation of the PIMA Point-of-Care CD4 Analyzer in VCT Clinics in Zimbabwe. J Acquir Immune Defic Syndr 55:1–7

    Article  Google Scholar 

  24. i-STAT® System | Point-of-Care Testing | Handheld Blood Analyzer | Abbott Point of Care.com. http://www.abbottpointofcare.com/. Accessed 12 Nov 2012

  25. SEC Info—I Stat Corporation/DE—10-K—For 12/31/02. http://www.secinfo.com/dqtWy.29.htm#ecri. Accessed 12 Nov 2012

  26. Abaxis—Home. http://www.abaxis.com/index.asp. Accessed 12 Nov 2012

  27. FSB 100: Top Small Businesses—Abaxis Inc. (ABAX)—FORTUNE Small Business. http://money.cnn.com/magazines/fsb/fsb100/2009/snapshots/45.html. Accessed 12 Nov 2012

  28. Siemens Global Website. http://www.siemens.com/entry/cc/en/. Accessed 12 Nov 2012

  29. I-Micronews—MICROFLUIDICS: Samsung ventures into medical device market. http://www.i-micronews.com/lectureArticle.asp?id=5168. Accessed 12 Nov 2012

  30. Welcome to the Medical Device Space Samsung. http://www.medgadget.com/archives/2010/07/welcome_to_the_medical_device_space_samsung_1.html. Accessed 12 Nov 2012

  31. Claros Diagnostics—Corporate Overview. http://www.opko.com/. Accessed 22 Aug 2010

  32. Prostate Cancer Results While You Wait—Technology Review. http://www.technologyreview.com/printer_friendly_article.aspx?id=24932. Accessed 12 Nov 2012

  33. BVGH Reports | Global Health R&D | BIO Ventures for Global Health (BVGH). http://www.bvgh.org/Biopharmaceutical-Solutions/Data-Center/BVGH-Reports.aspx. Accessed 14 June 2011

  34. Diagnostics For All. http://www.dfa.org/. Accessed 12 Nov 2012

  35. Posthuma-Trumpie GA, Korf J, Amerongen A (2008) Lateral flow (immuno)assay: its strengths, weaknesses, opportunities and threats. A literature survey. Anal Bioanal Chem 393:569–582

    Article  Google Scholar 

  36. Inverness stays in acquisition mode | IVD Technology. http://www.ivdtechnology.com/article/inverness-stays-acquisition-mode. Accessed 12 Nov 2012

  37. Halperin A (2007, March 26) A Hefty Price for Biosite. BusinessWeek: http://www.businessweek.com/stories/2007-03-26/a-hefty-price-for-biositebusinessweek-business-news-stock-market-and-financial-advice Accessed 06 Oct 2012

  38. Inverness completes Biosite acquisition—Daily Business Update—The Boston Globe. http://www.boston.com/business/ticker/2007/06/inverness_compl.html. Accessed 12 Nov 2012

  39. Biosite agrees to Inverness acquisition for $92.5 per share—Mass High Tech Business News. http://www.masshightech.com/stories/2007/05/14/daily39-Biosite-agrees-to-Inverness-acquisition-for-925-per-share.html. Accessed 12 Nov 2012

  40. Biosite® Inc. Web Site—Products. http://www.alere.com/us/en.html. Accessed 29 Nov 2010

  41. Quanterix—The Leader in Single Molecule Analysis. http://www.quanterix.com/. Accessed 12 Nov 2012

  42. Rissin DM et al (2010) Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations. Nat Biotechnol 28:595–599

    Article  CAS  Google Scholar 

  43. Boston Microfluidics. http://www.boston­microfluidics.com/. Accessed 12 Nov 2012

  44. Plexigen. http://www.plexigen.com/. Accessed 30 Nov 2010

  45. Fitzgerald SP et al (2005) Development of a high-throughput automated analyzer using biochip array technology. Clin Chem 51:1165–1176

    Article  CAS  Google Scholar 

  46. Randox Laboratories. http://www.randox.com/index.php. Accessed 12 Nov 2012

  47. Better ImmunoAssays through Innovative Microfluidics—Siloam Biosciences. https://www.siloambio.com/. Accessed 12 Nov 2012

  48. Davies K (2010) The $1,000 Genome: The revolution in DNA sequencing and the new era of personalized medicine simon and schuster

    Google Scholar 

  49. The $30 Genome?—Technology Review. http://technologyreview.com/biomedicine/25481/?mod=related. Accessed 12 Nov 2012

  50. GnuBio Enters Next-Generation Sequencing Sweepstakes—Bio-IT World. http://www.bio-itworld.com/news/06/02/10/Gnubio-sequencing-debut-consumer-genetics.html. Accessed 12 Nov 2012

  51. GnuBIO ahead of schedule with DNA sequencing plans—Mass High Tech Business News. http://www.masshightech.com/­stories/2011/06/06/daily22-GnuBIO-ahead-of-schedule-with-DNA-sequencing-plans.html. Accessed 12 Nov 2012

  52. Cepheid | GeneXpert System. http://www.cepheid.com/systems-and-software/genexpert-system/. Accessed 12 Nov 2012

  53. Boehme CC et al (2010) Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med 363:1005–1015

    Article  CAS  Google Scholar 

  54. Small PM, Pai M (2010) Tuberculosis diagnosis—time for a game change. N Engl J Med 363:1070–1071

    Article  CAS  Google Scholar 

  55. Automated Test for Drug-Resistant Tuberculosis Gives Results in Hours—NYTimes.com. http://www.nytimes.com/2010/09/07/health/07global.html. Accessed 12 Nov 2012

  56. Cepheid Reports Record Revenue of $44.8 Million—FierceHealthcare. http://www.fiercehealthcare.com/press-releases/cepheid-reports-record-revenue-44-8-million. Accessed 12 Nov 2012

  57. NORCHIP. http://www.norchip.com/. Accessed 12 Nov 2012

  58. Future Science News and Analysis. Cancer Screening Made Simple, Thanks to Micro-Fluidic Technology —Science Daily. http://www.sciencedaily.com/releases/2010/10/101014113914.html. Accessed 06 Oct 2012

  59. Biolithic | Consumer Diagnostic Devices. http://www.biolithic.com/. Accessed 12 Nov 2012

  60. Magna Diagnostics. http://magnadiagnostics.com/. Accessed 12 Nov 2012

  61. Shoveling Water—Technology Review. http://www.technologyreview.com/biomedicine/24086/. Accessed 12 Nov 2012

  62. Abe Lee tells Kathleen Too about the fundamentals of micro- and nanofluidics and lab-on-a-chip devices. http://www.rsc.org/Publishing/ChemTech/Volume/2009/05/Abe_Lee_interview.asp. Accessed 12 Nov 2012

  63. Blow N (2007) Microfluidics: in search of a killer application. Nat Meth 4:665–670

    Article  CAS  Google Scholar 

  64. Blow N (2009) Microfluidics: the great divide. Nat Meth 6:683–686

    Article  CAS  Google Scholar 

  65. Becker H (2009) Hype, hope and hubris: the quest for the killer application in microfluidics. Lab Chip 9:2119–2122

    Article  CAS  Google Scholar 

  66. The Failed Promise of Innovation in the U.S.—BusinessWeek. http://www.businessweek.com/magazine/content/09_24/b4135000953288.htm. Accessed 12 Nov 2012

  67. medco.com®: About Medco, latest news. http://www.medcohealth.com/medco/corporate/home.jsp?ltSess=y&articleID=CorpAlertMedco_physician_use_gen_tests. Accessed 01 Dec 2010

  68. Stanek EJ et al (2012) Adoption of pharmacogenomic testing by US physicians: results of a nationwide survey. Clin Pharmacol Ther. 91(3):450–458

    Google Scholar 

  69. F.D.A. Faults 5 Companies on Genetic Tests—NYTimes.com. http://www.nytimes.com/2010/06/12/health/12genome.html. Accessed 12 Nov 2012

  70. Daktari Diagnostics Closes $2.8M Series A Round to Combat Global HIV Crisis | Xconomy. http://www.xconomy.com/boston/2009/09/04/daktari-diagnostics-closes-28m-series-a-round-to-combat-global-hiv-crisis/. Accessed 12 Nov 2012

  71. The Boomerang: Healthcare Innovation Goes Where it Must, To the Developing World  «  Boston Biotech Watch. http://bostonbiotechwatch.com/2010/05/27/the-boomerang-healthcare-innovation-goes-where-it-must-to-the-developing-world/. Accessed 12 Nov 2012

  72. Russell J (2010) Alere Investor Presentation, BMO Capital Markets 2010 Healthcare Conference. http://investor.alere.com/news/upload/Alere_Investor_presentation_5-Aug-2010.pdf. Accessed 01 Dec 2010

  73. Becker H (2010) Collective wisdom. Lab Chip 10:1351–1354

    Article  CAS  Google Scholar 

  74. Lab on a chip and Microfluidic Devices (a.k.a., Microfluidics) | LinkedIn. http://www.linkedin.com/groups?mostPopular=&gid=713657. Accessed 12 Nov 2012

  75. Russell J (2010) Alere Investor Presentation, BMO Capital Markets 2010 Healthcare Conference. http://investor.alere.com/news/upload/Alere_Investor_presentation_5-Aug-2010.pdf. Accessed 01 Dec 2010

  76. Becker H (2010) Collective wisdom. Lab Chip 10:1351–1354

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Wyss Institute of Biologically Inspired Engineering at Harvard University, Brookline, MA, USA

    Lily Kim

Authors
  1. Lily Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lily Kim .

Editor information

Editors and Affiliations

  1. Key Laboratory for Organic Electronics &, Information Displays (KLOEID), Nanjing Univ. of Posts&Telecommunication, Jia Sheng Hua Yuan, No.2 Building Room 201, Nanjing, 210013, Jiangsu, China, People's Republic

    Gareth Jenkins

  2. Scientific & Medical Communications Cons, avenue Paul Santy 1C, Ecully, 69130, France

    Colin D. Mansfield

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media,LLC

About this protocol

Cite this protocol

Kim, L. (2013). Overview of the Microfluidic Diagnostics Commercial Landscape. In: Jenkins, G., Mansfield, C. (eds) Microfluidic Diagnostics. Methods in Molecular Biology, vol 949. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-134-9_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-62703-134-9_5

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-133-2

  • Online ISBN: 978-1-62703-134-9

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics

Search

Navigation