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The Effect of Diet on Protein Modification by Ethanol Metabolites

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Alcohol, Nutrition, and Health Consequences

Part of the book series: Nutrition and Health ((NH))

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Abstract

Alcohol (ethanol) is the most widely abused drug in Western societies and, as such, is a major cause of morbidity and mortality, leading to major social and economic costs. Despite an intensive research effort over many years, the main mechanisms by which alcohol exerts its toxicity remain largely elusive or unclear. This seems strange for such a simple molecule which has been associated with disease since at least Roman times. However, what is becoming clear is that alcohol-related tissue injury and disease is clearly multifactorial in nature, with some damage by direct toxicity while other damage occurs through indirect mechanisms. Further, it appears that at least some individuals appear to be genetically predisposed to injury, particularly to the liver, that gender can play a role, and that dietary components can influence the severity of the injury. The main tissues affected by long-term alcohol abuse include the liver, brain, skeletal muscle, cardiac muscle and the pancreas.

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Acknowledgements

Adduct formation in alcohol abuse has been part of my scientific life ever since I started my first postdoctoral position. During that time, I have enjoyed working with many academic colleagues and research students. I would particularly like to thank Professor John de Jersey and Associate Professor Peter Wilce for their friendship, help and guidance over the years. I would also like to thank the many research students that have passed through my laboratory during this time. Next, I would like to thank my international collaborators, Professors Dean Tuma and Geoffrey Thiele (University of Nebraska, Omaha) Professor Victor Preedy (King’s College London) and Professor Onni Niemela (Univerity of Oulu, Finland) for enduring the tyranny of distance and working with someone “downunder”. Finally I want to thank my wife, Lindy, and daughters, Lizzie, Jenny and Vikki for their continuing love and support.

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  1. Biochemistry and Molecular Biology, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia

    Simon Worrall B.Sc. (Hons), Ph.D.

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  1. Simon Worrall B.Sc. (Hons), Ph.D.
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Correspondence to Simon Worrall B.Sc. (Hons), Ph.D. .

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  1. Arizona Health Science Center, Mel and Enid Zuckerman College of Public, University of Arizona, 1501 N. Campbell Ave. ROOM 4335, TUCSON, 85724-5155, Arizona, USA

    Ronald Ross Watson

  2. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

  3. Division of Health Promotion Sciences, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin Avenue, Tucson, 85724, Arizona, USA

    Sherma Zibadi

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Worrall, S. (2013). The Effect of Diet on Protein Modification by Ethanol Metabolites. In: Watson, R., Preedy, V., Zibadi, S. (eds) Alcohol, Nutrition, and Health Consequences. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-047-2_9

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