Abstract
In surgical repair for heart disease, it is sometimes necessary to fill or replace a pathological tissue or defect with autologous graft tissue or a foreign grafting material. To date, (1) autologous pericardium, (2) allograft, (3) xenograft, and (4) artificial graft (e.g., Dacron, Teflon, Gore-Tex) have been used as graft materials. These grafts, however, lack growth potential, are associated with increased risk of thrombosis and infection, and have limited durability, thus increasing the morbidity and mortality of their application. Vascular tissue engineering is a relatively new concept proposed in the latter half of the 1980s. It aims to produce neotissue from autologous cells with biodegradable polymer as a scaffold by the application of engineering and biological principles. The greatest advantage of tissue constructed by tissue engineering is that the scaffold polymer is completely biodegraded as cells fill the extracellular stroma, and foreign materials do not remain at later time points after transplant. In this review, we provide an overview of our work to demonstrate the advantages of tissue-engineered vascular grafts in animal models and in human clinical applications using autologous cells and biodegradable scaffolds.
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Abbreviations
- Ac-LDL:
-
Acetylated low-density lipoprotein
- EPC:
-
Endothelial progenitor cell
- PTFE:
-
Polytetrafluoroethylene
References
Wells W, Malas M, Baker CJ, Quardt SM, Barr ML (2003 Aug) Depopulated vena caval homograft: a new venous conduit. J Thorac Cardiovasc Surg 126(2):498–503
Giannico S, Hammad F, Amodeo A, Michielon G, Drago F, Turchetta A et al (2006) Clinical outcome of 193 extracardiac Fontan patients: the first 15 years. J Am Coll Cardiol 47(10):2065–2073
Petrossian E, Reddy VM, McElhinney DB, Akkersdijk GP, Moore P, Parry AJ et al (1999) Early results of the extracardiac conduit Fontan operation. J Thorac Cardiovasc Surg 117(4):688–696
Homann M, Haehnel JC, Mendler N, Paek SU, Holper K, Meisner H et al (2000) Reconstruction of the RVOT with valved biological conduits: 25 years experience with allografts and xenografts. Eur J Cardiothorac Surg 17(6):624–630
Stark J (1998) The use of valved conduits in pediatric cardiac surgery. Pediatr Cardiol 19(4):282–288
Cleveland DC, Williams WG, Razzouk AJ, Trusler GA, Rebeyka IM, Duffy L et al (1992) Failure of cryopreserved homograft valved conduits in the pulmonary circulation. Circulation 86(5 Suppl):II150–II153
Jonas RA, Freed MD, Mayer JE Jr, Castaneda AR (1985) Long-term follow-up of patients with synthetic right heart conduits. Circulation 72(3 Pt 2):II77–II83
Bermudez CA, Dearani JA, Puga FJ, Schaff HV, Warnes CA, O’Leary PW et al (2004) Late results of the peel operation for replacement of failing extracardiac conduits. Ann Thorac Surg 77(3):881–887, discussion 8
Karamlou T, Ungerleider RM, Alsoufi B, Burch G, Silberbach M, Reller M et al (2005) Oversizing pulmonary homograft conduits does not significantly decrease allograft failure in children. Eur J Cardiothorac Surg 27(4):548–553
Langer R, Vacanti JP (1993) Tissue engineering. Science 260(5110):920–926
Shinoka T, Shum-Tim D, Ma PX, Tanel RE, Isogai N, Langer R et al (1998) Creation of viable pulmonary artery autografts through tissue engineering. J Thorac Cardiovasc Surg 115(3):536–545, discussion 45–6
Watanabe M, Shin’oka T, Tohyama S, Hibino N, Konuma T, Matsumura G et al (2001) Tissue-engineered vascular autograft: inferior vena cava replacement in a dog model. Tissue Eng 7(4):429–439
Shin’oka T, Matsumura G, Hibino N, Naito Y, Watanabe M, Konuma T et al (2005) Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells. J Thorac Cardiovasc Surg 129(6):1330–1338
Poh M, Boyer M, Solan A, Dahl SL, Pedrotty D, Banik SS et al (2005) Blood vessels engineered from human cells. Lancet 365(9477):2122–2124
Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T et al (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275(5302):964–967
Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M et al (1999) Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 85(3):221–228
Shi Q, Rafii S, Wu MH, Wijelath ES, Yu C, Ishida A et al (1998) Evidence for circulating bone marrow-derived endothelial cells. Blood 92(2):362–367
Noishiki Y, Tomizawa Y, Yamane Y, Matsumoto A (1996) Autocrine angiogenic vascular prosthesis with bone marrow transplantation. Nat Med 2(1):90–93
Matsumura G, Miyagawa-Tomita S, Shin’oka T, Ikada Y, Kurosawa H (2003) First evidence that bone marrow cells contribute to the construction of tissue-engineered vascular autografts in vivo. Circulation 108(14):1729–1734
Hibino N, Shin’oka T, Matsumura G, Ikada Y, Kurosawa H (2005) The tissue-engineered vascular graft using bone marrow without culture. J Thorac Cardiovasc Surg 129(5):1064–1070
Matsumura G, Ishihara Y, Miyagawa-Tomita S, Ikada Y, Matsuda S, Kurosawa H et al (2006) Evaluation of tissue-engineered vascular autografts. Tissue Eng 12(11):3075–3083
Brennan MP, Dardik A, Hibino N, Roh JD, Nelson GN, Papademitris X et al (2008) Tissue-engineered vascular grafts demonstrate evidence of growth and development when implanted in a juvenile animal model. Ann Surg 248(3):370–377
Shin’oka T, Imai Y, Ikada Y (2001) Transplantation of a tissue-engineered pulmonary artery. N Engl J Med 344(7):532–533
Hibino N, McGillicuddy E, Matsumura G, Ichihara Y, Naito Y, Breuer C et al (2010) Late-term results of tissue-engineered vascular grafts in humans. J Thorac Cardiovasc Surg 139(2):431–436, 6e1–6e2
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Hibino, N., Breuer, C., Shinoka, T. (2011). Restoring Blood Vessels. In: Bernstein, H. (eds) Tissue Engineering in Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-61779-322-6_11
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DOI: https://doi.org/10.1007/978-1-61779-322-6_11
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