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DISC1 Mouse Models

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Book cover Animal Models of Schizophrenia and Related Disorders

Part of the book series: Neuromethods ((NM,volume 59))

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Abstract

Disrupted-in-Schizophrenia 1 (DISC1) is a strong candidate gene for schizophrenia and major mental disorders. After its discovery in the Scottish chromosomal translocation, DISC1 has gained considerable attention in neuropsychiatric research. Recent studies have implicated DISC1 in fundamental processes of neurodevelopment and adulthood neuroplasticity. To get more insights into the functions of DISC1 in vivo, several mouse DISC1 models have been generated based on different approaches, including constitutive and inducible over-expression of different fragments of DISC1, targeted mutagenesis, and viral vector knockdown. Each model has provided important information regarding DISC1 functions and helped in elucidating the molecular pathways underlying behavioral disorders. The existing models also serve as valuable tools to address complex issues of the pathogenesis of schizophrenia, including gene–gene and gene–environment interactions. Here, we critically overview current DISC1 mouse models. Future directions in DISC1 mouse models and alternative approaches are discussed.

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Authors and Affiliations

  1. Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA

    Yavuz Ayhan

  2. Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA

    Hanna Jaaro-Peled

  3. Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA

    Akira Sawa

  4. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Mikhail V. Pletnikov

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  1. Yavuz Ayhan
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  4. Mikhail V. Pletnikov
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Correspondence to Mikhail V. Pletnikov .

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  1. School of Medicine, Depts. of Anatomy & Neurobiology, University of Maryland, Penn St. 20, Baltimore, 21201, Maryland, USA

    Patricio O'Donnell

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Ayhan, Y., Jaaro-Peled, H., Sawa, A., Pletnikov, M.V. (2011). DISC1 Mouse Models. In: O'Donnell, P. (eds) Animal Models of Schizophrenia and Related Disorders. Neuromethods, vol 59. Humana Press. https://doi.org/10.1007/978-1-61779-157-4_9

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  • DOI: https://doi.org/10.1007/978-1-61779-157-4_9

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-156-7

  • Online ISBN: 978-1-61779-157-4

  • eBook Packages: Springer Protocols

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