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Animal Models of Alcohol-Induced Dementia

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Animal Models of Dementia

Part of the book series: Neuromethods ((NM,volume 48))

Abstract

Alcoholic dementia is a disorder characterized by multiple cognitive deficits that include memory impairment associated with one or more cognitive disturbances listed in the present text. First, we characterize the disorder and describe aspects of using nonhuman models for studying specific and particular patterns of behavioral failures and biological dysfunctions found in cases of chronic alcohol consumption. Some kinds of animal models are depicted. Although there is no experimental model that displays all aspects considered as criteria for the diagnosis of alcoholic dementia, an animal model that is considered to be the most satisfactory to study behavioral and neurobiological aspects of this disease is that in which both high/chronic ethanol exposure and thiamine deficiency variables could be controlled. In this chapter, we show that animal models that manipulate only a single recognized etiological factor are less effective to elucidate the multiple influences that lead to alcoholic dementia. We conclude that even considering that only particular aspects of this disease could be approached using experimental animals; these studies can shed light on the biological processes, causing specific and particular patterns of cognitive failure.

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Authors and Affiliations

  1. Laboratório de Neurociência Comportamental e Molecular – LaNeC, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    Angela Maria Ribeiro & Silvia R. Castanheira Pereira

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  1. Angela Maria Ribeiro
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  2. Silvia R. Castanheira Pereira
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Editors and Affiliations

  1. Institute Born-Bunge, Lab of Neurochemistry & Behaviour, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium

    Peter Paul De Deyn

  2. Institute Born-Bunge, Lab of Neurochemistry & Behaviour, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium

    Debby Van Dam

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Ribeiro, A.M., Pereira, S.R.C. (2011). Animal Models of Alcohol-Induced Dementia. In: De Deyn, P., Van Dam, D. (eds) Animal Models of Dementia. Neuromethods, vol 48. Humana Press. https://doi.org/10.1007/978-1-60761-898-0_33

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  • DOI: https://doi.org/10.1007/978-1-60761-898-0_33

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-897-3

  • Online ISBN: 978-1-60761-898-0

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