Abstract
Leishmaniasis is a vector-borne disease caused by the Leishmania parasite and transmitted by the bite of Phlebotomine sand flies. Approximately 350 million people are at risk for this neglected disease with an annual incidence of two million cases and a loss of 2,357,000 disability-adjusted life years [1, 2]. Leishmaniasis has multiple clinical manifestations ranging from cutaneous, mucocutaneous and diffuse, to visceral leishmaniasis; the latter being fatal if untreated [1]. To add to the complexity of this disease, different Leishmania species are responsible for the different disease manifestations and the different Leishmania parasites are transmitted by different sand fly species.
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References
Desjeux P (2004) Leishmaniasis, Nat Rev Microbiol 2: 692
Alvar J, Yactayo S, Bernm C (2006) Leishmaniasis and poverty, Trends Parasitol 22: 552–557
Sacks D & Kamhawi S (2001) Molecular aspects of parasite-vector and vector-host interactions in leishmaniasis, Annu Rev Microbiol 55: 453–483
Ramalho-Ortigao M, Jochim R C, Anderson J M et al (2007) Exploring the midgut transcriptome of Phlebotomus papatasi: comparative analysis of expression profiles of sugar-fed, blood-fed and Leishmania-major-infected sandflies, BMC Genomics 8: 300
Kamhawi S, Ramalho-Ortigao M, Pham V M et al (2004) A role for insect galectins in parasite survival, Cell 119: 329–341
Jochim RC, Teixeira C R, Laughinghouse A et al (2008) The midgut transcriptome of Lutzomyia longipalpis: comparative analysis of cDNA libraries from sugar-fed, blood-fed, post-digested and Leishmania infantum chagasi-infected sand flies, BMC Genomics 9: 15
Ribeiro JM (1987) Role of saliva in blood-feeding by arthropods, Annu Rev Entomol 32: 463–478
Titus RG & Ribeiro J M (1988) Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity, Science 239: 1306–1308
Kamhawi S, Belkaid Y, Modi G et al (2000) Protection against cutaneous leishmaniasis resulting from bites of uninfected sand flies, Science 290: 1351–1354
Wikel SK, Ramachandra R N, Bergman D K et al (1997) Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks, Infect Immun 65: 335–338
Labuda M, Trimnell A R, Lickova M et al (2006) An antivector vaccine protects against a lethal vector-borne pathogen, PLoS Pathog 2: e27
Marsollier L, Deniaux E, Brodin P et al (2007) Protection against Mycobacterium ulcerans lesion development by exposure to aquatic insect saliva, PLoS Med 4: e64
Morris RV, Shoemaker C B, David J R et al (2001) Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection, J Immunol 16: 5226–5230
Valenzuela JG, Belkaid Y, Garfield M K et al (2001) Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein, J Exp Med 194: 331–342
Anderson JM, Oliveira F, Kamhawi S et al (2006) Comparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis, BMC Genomics 7: 52
Valenzuela JG, Garfield M, Rowton E D et al (2004) Identification of the most abundant secreted proteins from the salivary glands of the sand fly Lutzomyia longipalpis, vector of Leishmania chagasi, J Exp Biol 207: 3717–3729
Oliveira F, Kamhawi S, Seitz A E et al (2006) From transcriptome to immunome: identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library, Vaccine 24: 374–390
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Valenzuela, J.G. (2010). Targeting the Messenger: Vector-Based Vaccines to Control Leishmania Infection and Transmission. In: Georgiev, V. (eds) National Institute of Allergy and Infectious Diseases, NIH. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-512-5_43
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DOI: https://doi.org/10.1007/978-1-60761-512-5_43
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