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Why Study Mouse Retroviruses?

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National Institute of Allergy and Infectious Diseases, NIH

Part of the book series: Infectious Disease ((ID))

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Abstract

Retroviruses are a unique group of viruses that insert their genetic material into the host genome and cause a variety of diseases ranging from AIDS in humans infected with human immunodeficiency virus (HIV) to leukemia in humans infected with human T cell lymphotropic virus-1 (HTLV-1). Before retroviruses were discovered in humans, they had been studied for many years in mice and other species, mainly because of their interesting ability to cause cancer. As an immunologist, I became interested in studying mouse retroviruses because of intriguing work by Bruce Chesebro who showed that numerous immunological host genes controlled the ability of mouse retroviruses to cause disease [1]. While the immune systems of mice and humans are not identical, they are remarkably similar, and discoveries in mouse models have led to the development of diverse medical advances such as successful transplantation surgery, cancer therapies, antiviral drugs, and vaccines.

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Acknowledgements

This research was supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health.

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  1. Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA

    Kim J. Hasenkrug

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  1. Dept. Health & Human Services, National Institute of Health, Rockledge Drive 6610, Bethesda, 20892, Maryland, USA

    Vassil St. Georgiev

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Hasenkrug, K.J. (2010). Why Study Mouse Retroviruses?. In: Georgiev, V. (eds) National Institute of Allergy and Infectious Diseases, NIH. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-512-5_3

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  • DOI: https://doi.org/10.1007/978-1-60761-512-5_3

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  • Publisher Name: Humana Press, Totowa, NJ

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