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Iron Deficiency

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Iron Physiology and Pathophysiology in Humans

Part of the book series: Nutrition and Health ((NH))

Abstract

Iron deficiency is one of the most frequent hematological disorders encountered in the clinical setting. Iron is not only an element necessary for hemoglobin production but is also an important component of at least 200 cellular enzymes that are essential for normal cellular functions. The manifestations of iron deficiency vary from those related to the anemia of iron deficiency and to those related to tissue iron deficiency, not related to anemia. These include negative effects on work capacity [1] and endurance, low birth weight and preterm delivery, and effects on motor and mental development in infants, children, and adolescents [2–4]. These changes may lead to adverse socioeconomic and socioemotional [5] effects. Manifestations of anemia and tissue iron depletion often overlap and coexist.

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References

  1. Haas JD, Brownlie T. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr. 2001;131:676S–88.

    PubMed  CAS  Google Scholar 

  2. Halterman JS, Kaczorowski JM, Aligne CA, Auinger P, Szilagyi PG. Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. Pediatrics. 2001;107:1381–6.

    PubMed  CAS  Google Scholar 

  3. Algarin C, Peirano P, Garrido M, Pizarro F, Lozoff B. Iron deficiency anemia in infancy: long- lasting effects on auditory and visual system functioning. Pediatr Res. 2003;53:217–23.

    PubMed  CAS  Google Scholar 

  4. Verdon F, Burnand B, Stubi CL, et al. Iron supplementation for unexplained fatigue in non-anemic women: double blind randomized placebo controlled trial. BMJ. 2003;326:1124–7.

    PubMed  CAS  Google Scholar 

  5. Carter RC, Jacobson JL, Burden MJ, et al. Iron deficiency anemia and cognitive function in infancy. Pediatrics. 2010;126:e427–34.

    PubMed  Google Scholar 

  6. Willoughby JMT, Laitner SM. Audit of the investigation of iron deficiency anemia in a district general hospital, with sample guidelines for future practice. Postgrad Med J. 2000;76:218–22.

    PubMed  CAS  Google Scholar 

  7. Brugnara C, Schiller B, Moran J. Reticulocyte hemoglobin equivalent (Ret He) and assessment of iron-deficient states. Clin Lab Haematol. 2006;28:303–8.

    PubMed  CAS  Google Scholar 

  8. Macdougall IC, Cavill I, Hulme B, et al. Detection of functional iron-deficiency during erythropoietin treatment: a new approach. BMJ. 1992;304:225–6.

    PubMed  CAS  Google Scholar 

  9. Macdougall IC, Horl WH, Jacobs C, et al. European best practice guidelines 6–8: assessing and optimizing iron stores. Nephrol Dial Transplant. 2000;15:20–32.

    PubMed  Google Scholar 

  10. Goodnough LT, Skikne B, Brugnara C. Erythropoietin, iron, and erythropoiesis. Blood. 2000;96(3):823–33.

    PubMed  CAS  Google Scholar 

  11. Cook JD, Alvarado J, Gutniskey A, et al. Nutritional deficiency and anemia in Latin America: a collaborative study. Blood. 1971;38:591–603.

    PubMed  CAS  Google Scholar 

  12. Cohen JH, Haas JD. The comparison of mixed distribution analysis with a three-criteria model as a method for estimating the prevalence of iron deficiency anemia in Costa Rican children aged 12–23 months. Int J Epidemiol. 1999;28:82–9.

    PubMed  CAS  Google Scholar 

  13. Frith-Terhune Al, Cogswell ME, Khan LK, Will JC, Ramakrishnan U. Iron deficiency anemia: higher prevalence in Mexican American than in non-Hispanic white females in the third National Health and Nutrition Examination Survey. Am J Clin Nutr. 2000;72:963–8.

    PubMed  CAS  Google Scholar 

  14. Milman N, Byg KE, Mulvad G, Pedersen HS, Bjerregaard P. Haemoglobin concentrations appear to be lower in indigenous Greenlanders than in Danes: assessment of haemoglobin in 234 Greenlanders and in 2804 Danes. Eur J Haematol. 2001;67:23–9.

    PubMed  CAS  Google Scholar 

  15. Asobayire FS, Adou P, Davidsson L, Cook JD, Hurrell RF. Prevalence of iron deficiency with and without concurrent anemia in population groups with high prevalences of malaria and other infections: a study in cote d’lvoire. Am J Clin Nutr. 2001;74:776–82.

    PubMed  CAS  Google Scholar 

  16. Kitua AY, Smith TA, Alonso PL, et al. The role of low level plasmodium falciparum parasitemia in anemia among infants living in an area of intense and perennial transmission. Trop Med Int Health. 1997;2:325–39.

    PubMed  CAS  Google Scholar 

  17. Mast AE, Blinder MA, Lu Q, Flax S, Dietzen DJ. Clinical utility of the reticulocyte hemoglobin content in the diagnosis of iron deficiency. Blood. 2002;99:1489–92.

    PubMed  CAS  Google Scholar 

  18. Markovic M, Majkic-Singh N, Ignjatovic S, Singh S. Reticulocyte haemoglobin content vs. soluble transferrin receptor and ferritin index in iron deficiency anemia accompanied with inflammation. Int J of Lab Haematol. 2007;29:341–6.

    CAS  Google Scholar 

  19. Brugnara C, Zurakowski D, DiGnzio J, Boyd T, Platt O. Reticulocyte haemoglobin content to diagnose iron deficiency in children. JAMA. 1999;281:2225–30.

    PubMed  CAS  Google Scholar 

  20. Ullrich C, Wu A, Armsby C, et al. Screening healthy infants for iron deficiency using reticulocyte hemoglobin content. JAMA. 2005;294:924–30.

    PubMed  CAS  Google Scholar 

  21. Fishbane S, Galgano C, Langley Jr RC, Canfield W, Maesaka JK. Reticulocyte hemoglobin content in the evaluation of iron status of hemodialysis patients. Kidney Int. 1997;52:217–22.

    PubMed  CAS  Google Scholar 

  22. Kuvibidila S, Yu LC, Ode DL, Warrier RP, Mbefe V. Assessment of iron status of Zairian women of childbearing age by serum transferrin receptor. Am J Clin Nutr. 1994;60:603–9.

    PubMed  CAS  Google Scholar 

  23. Tarng DC, Huang TP, Chen TW, Yang WC. Erythropoietin hyporesponsiveness: from iron deficiency to iron overload. Kidney Int Soc Nephrol. 1995;69:S107–18.

    Google Scholar 

  24. Herbert V, Jayatilleke E, Shaw S, et al. Serum ferritin iron, a new test, measures human body iron stores uncompounded by inflammation. Stem Cells. 1997;15:291–6.

    PubMed  CAS  Google Scholar 

  25. Dale JC, Burritt MF, Zinsmeister AR. Diurnal variation of serum iron, iron-binding capacity, transferrin saturation, and ferritin levels. Am J Clin Pathol. 2002;117:802–8.

    PubMed  CAS  Google Scholar 

  26. Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. suppression of hepcidin during anemia requires erythropoietic activity. Blood. 2006;108:3730–5.

    PubMed  CAS  Google Scholar 

  27. Detivaud L, Nemeth E, Boudjema K, et al. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood. 2005;106:746–8.

    PubMed  CAS  Google Scholar 

  28. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003;101:2461–3.

    PubMed  CAS  Google Scholar 

  29. Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood. 2002;100:3776–81.

    PubMed  CAS  Google Scholar 

  30. Kemna E, Tjalsma H, Laarakkers C, Nemeth E, Willems H, Swinkels D. Novel urine hepcidin assay by mass spectrometry. Blood. 2005;106:3268–70.

    PubMed  CAS  Google Scholar 

  31. Ahluwalia N, Skikne BS, Savin V, Chonko A. Markers of masked iron deficiency and effectiveness of EPO therapy in chronic renal failure. Am J Kidney Dis. 1997;30(4):532–41.

    PubMed  CAS  Google Scholar 

  32. Shih YJ, Baynes RD, Hudson BG, Flowers CH, Skikne BS, Cook JD. Serum transferrin receptor is a truncated form of tissue receptor. J Biol Chem. 1990;265:19077–81.

    PubMed  CAS  Google Scholar 

  33. Cook JD, Skikne BS, Baynes RD. Serum transferrin receptor. Annu Rev Med. 1993;44:63–74.

    PubMed  CAS  Google Scholar 

  34. Skikne BS, Flowers CH, Cook JD. Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood. 1990;75:1870–6.

    PubMed  CAS  Google Scholar 

  35. Ferguson BJ, Skikne BS, Simpson KM, Baynes RD, Cook JD. Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J Lab Clin Med. 1992;119:385–90.

    PubMed  CAS  Google Scholar 

  36. Ahuwalia N, Lammi-Keefe CJ, Bendel RB. Iron deficiency and anemia of chronic disease in elderly women: a discriminant-analysis approach for differentiation. Am J Clin Nutr. 1995;61:590–6.

    Google Scholar 

  37. Suominen P, Punnonen K, Rajamaki A, Irjala K. Evaluation of new immunoenzymometric assay for measuring soluble transferrin receptor to detect iron deficiency in anemic patients. Clin Chem. 1997;43:1641–6.

    PubMed  CAS  Google Scholar 

  38. Nielsen OJ, Andersen LS, Hansen NE, Hansen TM. Serum transferrin receptor levels in anemic patients with rheumatoid arthritis. Scand J Clin Lab Invest. 1994;54:75–82.

    PubMed  CAS  Google Scholar 

  39. Siebert S, Williams BD, Henley R, Ellis R, Cavill I, Worwood M. Single value of serum transferrin receptor is not diagnostic for the absence of iron stores in anemic patients with rheumatoid arthritis. Clin Lab Haematol. 2003;25:155–60.

    PubMed  CAS  Google Scholar 

  40. Wians Jr FH, Urban JE, Keffer JH, Kroft SH. Discriminating between iron deficiency anemia and anemia of chronic disease using traditional indices of iron status vs transferrin receptor concentration. Am J Clin Pathol. 2001;115:112–8.

    PubMed  CAS  Google Scholar 

  41. Punnonen K, Irjala K, Rajamaki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood. 1997;89:1052–7.

    PubMed  CAS  Google Scholar 

  42. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011–23.

    PubMed  CAS  Google Scholar 

  43. Thuy PV, Berger J, Davidsson L, et al. Regular consumption of NaFeEDTA-Fortified Fish Sauce improves iron status and reduces the prevalence of anemia in anemic Vietnamese women. Am J Clin Nutr. 2003;78:284–90.

    PubMed  CAS  Google Scholar 

  44. Kogan AE, Filatov VL, Kara AN, Levina AA, Katrukha AG. Comparison of soluble and placental transferrin receptors as standards for the determination of soluble transferrin receptor in humans. Int J Lab Hematol. 2007;29:335–40.

    PubMed  CAS  Google Scholar 

  45. Souminen P, Punnonen K, Rajamaki A, Irjala K. Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subject with sub-clinical iron deficits. Blood. 1998;92:934–9.

    Google Scholar 

  46. Cook JD, Flowers CH, Skikne BS. An assessment of dried blood-spot technology for identifying iron deficiency. Blood. 1998;92:1807–13.

    PubMed  CAS  Google Scholar 

  47. Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood. 2003;9:3359–64.

    Google Scholar 

  48. Simmons WK, Cook JD, Bingham KC, et al. Evaluation of gastric delivery system for iron supplementation in pregnancy. Am J Clin Nutr. 1993;58:622–6.

    PubMed  CAS  Google Scholar 

  49. Tawfik O, O’Neal MF, Davis M, Cunningham MT, Skikne B, Chapman KD. A newly proposed iron stain quantitation method in bone marrow smears using an automated cellular imaging system. Am J Clin Pathol. 2006;126:643–4.

    Google Scholar 

  50. Fleming DJ, Jacques PF, Dallal GE, Tucker KL, Wilson PWF, Wood RJ. Dietary determinants of iron stores in a free-living elderly population. The Framingham heart study. Am J Clin Nutr. 1998;67:722–33.

    PubMed  CAS  Google Scholar 

  51. Cook JD, Dassenko SA, Whittaker P. Calcium supplementation: effect on iron absorption. Am J Clin Nutr. 1991;53:106–11.

    PubMed  CAS  Google Scholar 

  52. Hallberg L, Rossander-Hulten L, Brune M, Gleerup A. Calcium and iron absorption: mechanism of action and nutritional importance. Eur J Clin Nutr. 1992;46:317–27.

    PubMed  CAS  Google Scholar 

  53. Hallberg L, Brune M, Erlandsson M, Snadberg AS, Rossander-Hulten L. Calcium: effect of different amounts on nonheme – and heme-iron absorption in humans. Am J Clin Nutr. 1991;53:112–9.

    PubMed  CAS  Google Scholar 

  54. Roughead ZK, Zito CA, Hunt JR. Initial uptake and absorption of nonheme iron and absorption of heme iron in humans are unaffected by the addition of calcium as cheese to a meal with high iron bioavailability. Am J Clin Nutr. 2002;76:419–25.

    PubMed  CAS  Google Scholar 

  55. Beard JL. Iron requirements in adolescent females. J Nutr. 2000;130:440S–2.

    PubMed  CAS  Google Scholar 

  56. Hallberg L. Iron requirements, iron balance and iron deficiency in menstruating and pregnant women. In: Hallberg L, Asp NG, editors. Iron nutrition in health and disease. London: John Libbey & Co; 1996. p. 165–82.

    Google Scholar 

  57. Carriaga MT, Skikne BS, Finley B, Cutler B, Cook JD. Serum transferrin receptor for the detiction of iron deficiency in pregnancy. Am J Clin Nutr. 1991;54:1077–81.

    PubMed  CAS  Google Scholar 

  58. Milman N, Agger AO, Nielsen OJ. Iron supplementation during pregnancy. Dan Med Bull. 1991;38:471–6.

    PubMed  CAS  Google Scholar 

  59. Makrides M, Crowther CA, Gibson RA, Gibson RS, Skeaff CM. Efficacy and tolerability of low-dose iron supplements during pregnancy: a randomized controlled trial. Am J Clin Nutr. 2003;78:145–53.

    PubMed  CAS  Google Scholar 

  60. Skikne BS, Cook JD. Effect of enhanced eryrhropoiesis on iron absorption. J Lab Clin Med. 1992;20:746–54.

    Google Scholar 

  61. Skikne BS, Ahluwalia N, Fergusson B, Chonko A, Cook JD. Effects of erythropoietin therapy on iron absorption in chronic renal failure. J Lab Clin Med. 2000;135:452–8.

    PubMed  CAS  Google Scholar 

  62. Raje D, Mukhtar H, Oshowo A, Ingham Clark C, Chir M. What proportion of patients referred to secondary care with iron deficiency anemia have colon cancer? Dis Colon Rectum. 2007;50:1211–4.

    PubMed  Google Scholar 

  63. Acher PL, Al-Mishlab T, Rahman M, Bates T. Iron deficiency anemia and delay in the diagnosis of colorectal cancer. Colorectal Dis. 2003;5:145–8.

    PubMed  CAS  Google Scholar 

  64. Bardella MT, Fredella C, Saladino V, et al. Gluten intolerance. Gender and age-related differences in symptoms. Scand J Gastroenterol. 2005;40:15–9.

    PubMed  Google Scholar 

  65. Rockey DC, Cello JP. Evaluation of the gastrointestinal tract in patients with iron-deficiency anemia. N Engl J Med. 1993;329:1691–5.

    PubMed  CAS  Google Scholar 

  66. McIntyre AS, Long RG. Prospective survey of investigations in outpatients referred with iron deficiency anemia. Gut. 1993;34:1102–7.

    PubMed  CAS  Google Scholar 

  67. Bini EJ, Micale PL, Weinshel EH. Evaluation of the gastrointestinal tract in pre-menopausal women with iron deficiency anemia. Am J Med. 1998;105:281–6.

    PubMed  CAS  Google Scholar 

  68. Dickey W, Hughes D. Prevalence of celiac disease and its endoscopic markers among patients having routine upper gastrointestinal endoscopy. Am J Gastroenterol. 1999;94:2182–6.

    PubMed  CAS  Google Scholar 

  69. Dickey W, Kenny BD, McMillan SA, Porter KG, McConnell JB. Gastric as well as duodenal biopsies may be useful in the investigation of iron deficiency anemia. Scand J Gastroenterol. 1997;32:469–72.

    PubMed  CAS  Google Scholar 

  70. Annibale B, Capurso G, Chistolini A, et al. Gastrointestinal causes of refractory iron deficiency anemia in patients without gastrointestinal symptoms. Am J Med. 2001;111:439–45.

    PubMed  CAS  Google Scholar 

  71. Choe YH, Kwon YS, Jung MK, et al. Helicobacter pylori-associated iron-deficiency anemia in adolescent female athletes. J Pediatr. 2001;139:100–4.

    PubMed  CAS  Google Scholar 

  72. Annibale B, Marignani M, Monarca B, et al. Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis. Annu Int Med. 1999;131:668–72.

    CAS  Google Scholar 

  73. Hershko C, Hoffbrand AV, Keret D, et al. Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia. Haematologica. 2005;90:585–95.

    PubMed  CAS  Google Scholar 

  74. Hershko C, Ronson A, Souroujon M, et al. Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion. Blood. 2006;107:1673–9.

    PubMed  CAS  Google Scholar 

  75. Hershko C, Ianculovich M, Souroujon M. A hematologist’s view of unexplained iron deficiency anemia in males: impact of Helicobacter pylori eradication. Blood Cells Mol Dis. 2007;38:45–53.

    PubMed  CAS  Google Scholar 

  76. Milman N, Rosenstock S, Andersen L, et al. Serum ferritin, hemoglobin, and Helicobacter pylori infection: a seroepidemiologic survey comprising 2794 Danish adults. Gastroenterology. 1998;115:268–74.

    PubMed  CAS  Google Scholar 

  77. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med. 2002;347:1175–86.

    PubMed  CAS  Google Scholar 

  78. Choe YH, Kim SK, Son BK, et al. Randomized placebo-controlled trial of Helicobacter pylori eradication for iron-deficiency anemia in preadolescent children and adolescents. Helicobacter. 1999;4:135–9.

    PubMed  CAS  Google Scholar 

  79. Choe YH, Lee JE, Kim SK. Effect of helicobacter pylori eradication on sideropenic refractory anaemia in adolescent girls with Helicobacter pylori infection. Acta Paediatr. 2000;89:154–7.

    PubMed  CAS  Google Scholar 

  80. Annibale B, Capurso G, Lahner E, et al. Concomitant alterations in intragastric pH and ascorbic acid concentration in patients with Helicobacter pylori gastritis and associated iron deficiency anaemia. Gut. 2003;52:496–501.

    PubMed  CAS  Google Scholar 

  81. Faber K, Bloch CE. Über die pathologischen Veränderungen am digestion-stractus bei der perniciösen anämie und über die sogenannte darm atrophie. Zeitschrift Klin Med. 1900;40:98.

    Google Scholar 

  82. Faber K. Achylia gastrica mit Anämie. Medizinishe Klinik. 1909;5:1310–25.

    Google Scholar 

  83. Faber K. Anämische Zustände bei der chronischen Achylia Gastrica. Klin Echnschr. 1913;50:958.

    Google Scholar 

  84. Faber K, Gram HC. Relations between achylia gastrica and simple and pernicious anemia. Arch Intern Med. 1924;34:658–68.

    CAS  Google Scholar 

  85. Wintrobe MM, Beebe RT. Idiopathic hypochromic anemia. Medicine. 1933;12:187–243.

    Google Scholar 

  86. Hershko C, Patz J, Ronson A. The anemia of achylia gastrica revisited. Blood Cells Mol Dis. 2007;39:178–83.

    PubMed  Google Scholar 

  87. Beutler E, Fairbanks VF, Fahey JL. Clinical disorders of iron metabolism. New York: Grune& Stratton; 1963. p. 80–3.

    Google Scholar 

  88. Davidson WMB, Markson JL. The gastric mucosa in iron deficiency anaemia. Lancet. 1955;269:639–43.

    PubMed  CAS  Google Scholar 

  89. Badenoch J, Evans JR, Richards WCD. The stomach in hypochromic anemia. Brit J Haematol. 1957;3:175–85.

    CAS  Google Scholar 

  90. Lees F, Rosenthal FD. Gastric mucosal lesions before and after treatment in iron-deficiency anemia. Quart J Med. 1958;27:19–26.

    PubMed  CAS  Google Scholar 

  91. Editorial. Achlorhydria and anaemia. Lancet. 1960;2:27–8.

    Google Scholar 

  92. Dagg JH, Goldberg A, Gibbs WN, Anderson JR. Detection of latent pernicious anemia in iron -deficiency anemia. Brit Med J. 1966;2:619–21.

    PubMed  CAS  Google Scholar 

  93. Cook JD, Brown GM, Valberg LS. The effect of achylia gastrica on iron absorption. J Clin Invest. 1964;43:1185–91.

    PubMed  CAS  Google Scholar 

  94. Schade SG, Cohen RJ, Conrad ME. The effect of hydrochloric acid on iron absorption. N Engl J Med. 1968;279:621–4.

    Google Scholar 

  95. Bezwoda W, Charlton R, Bothwell T, et al. The importance of gastric hydrochloric acid in the absorption of nonheme food iron. J Lab Clin Med. 1978;92:108–16.

    PubMed  CAS  Google Scholar 

  96. Stopeck A. Links between Helicobacter pylori infection, cobalamin deficiency, and pernicious anemia. Arch Intern Med. 2000;160:1229–30.

    PubMed  CAS  Google Scholar 

  97. Appelmelk BJ, Simoons-Smit I, Negrini R, et al. Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity. Infect Immun. 1996;64:2031–40.

    PubMed  CAS  Google Scholar 

  98. Negrini R, Savio A, Appelmelk BJ. Autoantibodies to gastric mucosa in Helicobacter pylori infection. [review]. Helicobacter. 1997;2:S13–6.

    PubMed  Google Scholar 

  99. Ma JY, Borch K, Sjostrand SE, et al. Positive corrélation between H, K-adenosine triphosphatase autoantibodies and Helicobacter pylori antibodies in patients with pernicious anemia. Scand J Gastroenterol. 1994;29:961–5.

    PubMed  CAS  Google Scholar 

  100. Claeys D, Faller G, Appelmelk BJ, et al. The gastric H+, K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy. Gastroenterology. 1998;115:340–7.

    PubMed  CAS  Google Scholar 

  101. Negrini R, Savio A, Poiesi C, et al. Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis. Gastroenterology. 1996;111:655–65.

    PubMed  CAS  Google Scholar 

  102. Jassel SV, Ardill JE, Fillmore D, et al. The rise in circulating gastrin with age is due to increases in gastric autoimmunity and Helicobacter pylori infection. QJM. 1999;92:373–7.

    PubMed  CAS  Google Scholar 

  103. Appelmelk BJ, Negrini R, Moran AP, Kuipers EJ. Molecular mimicry between Helicobacter pylori and the host. Trends Microbiol. 1997;5:70–3.

    PubMed  CAS  Google Scholar 

  104. Rad R, Schmid RM, Prinz C. Helicobacter pylori, iron deficiency, and gastric autoimmunity. Blood. 2006;107:4969–70.

    PubMed  CAS  Google Scholar 

  105. Annibale B, Di Giulio E, Caruana P, et al. The long-term effects of cure of Helicobacter pylori infection on patients with atrophic body gastritis. Aliment Pharmacol Ther. 2002;16:1723–31.

    PubMed  CAS  Google Scholar 

  106. Kaptan K, Beyan C, Ural AU, et al. Helicobacter pylori: is it a novel causative agent in vitamin B12 deficiency? Arch Intern Med. 2000;160:1349–53.

    PubMed  CAS  Google Scholar 

  107. Haruma K, Mihara M, Okamoto E, et al. Eradication of Helicobacter pylori increases gastric acidity in patients with atrophic gastritis of the corpus-evaluation of 24-h pH monitoring. Aliment Pharmacol Ther. 1999;13:155–62.

    PubMed  CAS  Google Scholar 

  108. McColl KEL, Murray LS, Gillen D, et al. Randomized trial of endoscopy with testing for Helicobacter pylori compared with non-invasive H pylori testing alone in the management of dyspepsia. BMJ. 2002;324:999–1002.

    PubMed  CAS  Google Scholar 

  109. Finberg KE. Iron-refractory iron deficiency anemia. Semin Hematol. 2009;46:378–86.

    PubMed  CAS  Google Scholar 

  110. DeMaeyer EM, Adiels-Tegman M. The prevalence of anemia in the world. World Health Stat Q. 1985;38:302–16.

    PubMed  CAS  Google Scholar 

  111. Looker AC, Dallman PR, Carroll MD, Gunter EW, Johnson CL. Prevalence of iron deficiency in the United States. JAMA. 1997;227:973–6.

    Google Scholar 

  112. Cook JD, Boy E, Flowers C, del Carmen Daroca M. The influence of high-altitude living on body iron. Blood. 2005;106:1441–6.

    PubMed  CAS  Google Scholar 

  113. Rahimova S, Perry GS, Sarbanescu F, et al. Prevalence of anemia among displaced and nondisplaced mothers and children – Azerbaijan, 2001. MMWR Morb Mortal Wkly Rep. 2004;53:610–4.

    Google Scholar 

  114. National Center for Health Statistics. Plan and Operation of the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994. Hyattsville: National Center for Health Statistics; 1994.

    Google Scholar 

  115. Brotanek JM, Gosz J, Weitzman M, Flores G. Iron deficiency in early childhood in the United States: risk factors and racial/ethnic disparities. Pediatrics. 2007;120:568–75.

    PubMed  Google Scholar 

  116. Nead KG, Halterman JS, Kaczorowski JM, Auinger P, Weitzman M. Overweight children and adolescents: a risk group for iron deficiency. Pediatrics. 2004;114:104–8.

    PubMed  Google Scholar 

  117. Pinhas-Hamiel O, Newfield RS, Koren I, Agmon A, Lilos P, Phillip M. Greater prevalence of iron II deficiency in overweight and obese children and adolescents. Int J Obes Relat Metab Disord. 2003;27:416–8.

    PubMed  CAS  Google Scholar 

  118. Zhou SJ, Gibson RA, Makrides M. Routine iron supplementation in pregnancy has no effect on iron status of children at six months and four years of age. J Pediatr. 2007;151:438–40.

    PubMed  CAS  Google Scholar 

  119. DePee S, Bloem MW, Sari M, Kiess L, Yip R, Kosen S. The high prevalence of low hemoglobin concentration among Indonisian infants aged 3–5 months is related to maternal anemia. J Nutr. 2002;132:2215–21.

    CAS  Google Scholar 

  120. Looker AC, Cogswell ME, Gunter EW. Iron deficiency – United States: 1999-2000. MMWR Weekly. 2002;51:897–9.

    Google Scholar 

  121. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104:22263–8.

    Google Scholar 

  122. Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110:1037–44.

    PubMed  CAS  Google Scholar 

  123. Berger J, Aguayo VM, Tellez W, Lujan C, Traissac P, San Miguel JL. Weekly iron supplementation is as effective as 5 day per week iron supplementation in Bolivian school children living at high altitude. Eur J Clin Nutr. 1997;51:381–6.

    PubMed  CAS  Google Scholar 

  124. Hurrell RF. Fortification: overcoming technical and practical barriers. J Nutr. 2002;132(Suppl):806S–12.

    PubMed  CAS  Google Scholar 

  125. Garby L, Areekul S. Iron supplementation in the Thai Fish sauce. Ann Trop Med Parasitol. 1974;68:467–76.

    PubMed  CAS  Google Scholar 

  126. Viteri FE, Alvarez E, Batres R, et al. Fortification of sugar with iron sodium ethylenediaminotetraacetate (FeNaEDTA) improves iron status in semirural Guatemalan populations. Am J Clin Nutr. 1995;61:1153–63.

    PubMed  CAS  Google Scholar 

  127. Ballot DE, MacPhail TH, Bothwell M, Gillooly M. Fortification of curry powder with NaFe(III)EDTA in an iron-deficient population. Am J Clin Nutr. 1989;49:162–9.

    PubMed  CAS  Google Scholar 

  128. Andang’o PEA, Osendarp SJM, Ayah R, West CE, et al. Efficacy of iron-fortified whole maize flour on iron status of school children in Kenya: a randomized controlled trial. Lancet. 2007;369:1799–806.

    PubMed  Google Scholar 

  129. Hurrell RF, Reddy MB, Dassenko SA, Cook JD, Shepherd D. Ferrous fumarate fortification of a chocolate drink powder. Brit J Nutr. 1991;65:271–83.

    PubMed  CAS  Google Scholar 

  130. Brise H, Hallberg L. Absorbability of different iron compounds. Acta Med Scand Suppl. 1962;17:23–37.

    Google Scholar 

  131. Cook JD, Reddy MB. Efficacy of weekly compared with daily iron supplementation. Am J Clin Nutr. 1995;62:117–20.

    PubMed  CAS  Google Scholar 

  132. Besarab A. More than a decade of experience and still no consensus: controversies in iron therapy. Clin J Am Soc Nephrol. 2006;1(Suppl 1):S1–3.

    PubMed  Google Scholar 

  133. KDOQI Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease: update 2006. Am J Kidney Dis 2006; 47(Suppl 3):S11–145.

    Google Scholar 

  134. Fishbane S, Ungureanu VD, Maesaka JK, Kaupke CJ, Lim V, Wish J. The safety of intravenous iron dextan in hemodialysis patients. Am J Kidney Dis. 1996;28:529–34.

    PubMed  CAS  Google Scholar 

  135. Michael B, Coyne DW, Fishbane S, et al. Sodium ferric gluconate complex in hemodialysis patients: adverse reactions compared to placebo and iron dextran. Kidney Int. 2002;61:1830–9.

    PubMed  CAS  Google Scholar 

  136. Miller HJ, Hu J, Valentine JK, Gable PS. Efficacy and tolerability of intravenous ferric gluconate in the treatment of iron deficiency anemia in patients without kidney disease. Arch Intern Med. 2007;167:1327–8.

    PubMed  CAS  Google Scholar 

  137. Charytan C, Schwenk MH, Al-Saloum MM, Spinowitz BS. Safety of iron sucrose in hemodialysis patients intolerant to other potential iron products. Nephron Clin Pract. 2004;96:C63–6.

    PubMed  CAS  Google Scholar 

  138. Lu M, Cohen MH, Rieves D, Pazdur R. FDA report: ferumoxytol for intravenous iron therapy in adult patients with chronic kidney disease. Am J Hematol. 2010;85:315–9.

    PubMed  CAS  Google Scholar 

  139. Drueke T, Witko-Sarsat V, Massy Z, et al. Iron therapy, advanced oxidation protein products, and carotid artery intima-media thickness in end-stage renal disease. Circulation. 2002;106:2212–7.

    PubMed  Google Scholar 

  140. Reis KA, Guz G, Ozdemir H, et al. Intravenous iron therapy as a possible risk factor for atherosclerosis in end-stage renal disease. Int Heart J. 2005;46:255–64.

    PubMed  CAS  Google Scholar 

  141. Van Wyck D, Anderson J, Johnson K. Labile iron in parenteral iron formulations: a quantitative and comparative study. Nephrol Dial Transplant. 2004;19:561–5.

    PubMed  Google Scholar 

  142. Rooyakkers TM, Stroes ES, Kooistra MP, et al. Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo. Eur J Clin Invest. 2002;32(Suppl 1):9–16.

    PubMed  CAS  Google Scholar 

  143. Zager RA. Parenteral iron compounds potent oxidents but mainstays of anemia management in chronic renal disease. Clin J Am Soc Nephrol. 2006;1(Suppl 1):S24–31.

    PubMed  CAS  Google Scholar 

  144. Krafft A, Perewusnyk G, Hanseler E, Quack K, Huch R, Breymann C. Effect of postpartum iron supplementation on red cell and iron parameters in non-anemic iron-deficient women: a randomized placebo- controlled study. BJOG. 2005;112:445–50.

    PubMed  CAS  Google Scholar 

  145. Akesson A, Bjellerup P, Berglund M, Bremme K, Vahter M. Serum transferrin receptor;a specific marker of iron deficiency in pregnancy. Am J Clin Nutr. 1998;68:1241–6.

    PubMed  CAS  Google Scholar 

  146. Sinclair LM, Hinton PS. Prevalence of iron deficiency with and without anemia in recreationally active men and women. J Am Diet Assoc. 2005;105:975–8.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Celgene Corporation, Overland Park, KS, USA

    Barry Skikne M.D.

  2. Department of Hematology, Shaare Zedek Medical Center and Hebrew University of Jerusalem, Jerusalem, Israel

    Chaim Hershko M.D.

Authors
  1. Barry Skikne M.D.
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  2. Chaim Hershko M.D.
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Correspondence to Barry Skikne M.D. .

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  1. Bancroft Centre, Queensland Institute of Medical Research, Herston Road 300, Brisbane, 4029, Queensland, Australia

    Gregory J. Anderson

  2. Dept. Medicine &, Chao Family Comprehensive Cancer Ctr., University of California, Irvine, East 7th St. 5901, Long Beach, 90822, California, USA

    Gordon D. McLaren

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Skikne, B., Hershko, C. (2012). Iron Deficiency. In: Anderson, G., McLaren, G. (eds) Iron Physiology and Pathophysiology in Humans. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-60327-485-2_13

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