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The Integration of Metabolism and Cell Death

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Essentials of Apoptosis

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Abstract

Metabolism is a fundamental cellular process necessary for energy production and biosynthesis. While the biochemistry of basic metabolic pathways has been known for some time, how the metabolic state of a cell regulates fate decisions has remained poorly understood. In recent years, cellular metabolism has been shown to play an integral role in the regulation of apoptosis, in particular via interaction with the Bcl-2 family of proteins. This chapter focuses on the inherent relationships between metabolism and apoptosis, as well as several more intricate mechanisms of how apoptotic and metabolic machinery interact to determine cell fate under a variety of conditions, including a potential for the metabolic regulation of apoptosis in cancer.

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Authors and Affiliations

  1. Department of Pharmacology and Cancer Biology, Sarah W. Stedman Nutrition and Metabolism Center; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA

    Jeffrey C. Rathmell

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  1. Jonathan L. Coloff
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  2. Yuxing Zhao
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  3. Jeffrey C. Rathmell
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Correspondence to Jeffrey C. Rathmell .

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    © 2009 Humana Press, a part of Springer Science+Business Media, LLC

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    Coloff, J.L., Zhao, Y., Rathmell, J.C. (2009). The Integration of Metabolism and Cell Death. In: Dong, Z., Yin, XM. (eds) Essentials of Apoptosis. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-381-7_9

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