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The Dopamine Receptors pp 101–135Cite as

Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors

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Part of the book series: The Receptors ((REC))

Abstract

Drugs that are known to activate or block dopamine receptors are widely used for the treatment of a number of severe diseases. In most cases, dopaminergic drugs preferentially interact with the subtypes of the D2 family (D2, D3, D4). However, only minor selectivity has been observed between D2, D3, and D4. Nevertheless, in recent years D3 and D4 subtype-selective agonists, partial agonists, and antagonist have been developed. The most interesting structural features required for high selectivity and affinity are presented as well as structure–activity relationship (SAR) studies. Moreover, the use of subtype-selective radioligands is discussed.

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  1. Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany

    Olaf Prante

  2. Department of Chemistry and Pharmacy, Friedrich-Alexander University, Schuhstr. 19, 91052, Erlangen, Germany

    Miriam Dörfler & Peter Gmeiner

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    Kim A. Neve

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Prante, O., Dörfler, M., Gmeiner, P. (2010). Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors. In: Neve, K. (eds) The Dopamine Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-333-6_5

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