Abstract
Today, diabetic women have an increasing variety of safer and effective contraceptive methods. While more contraceptive trials in diabetic women are needed, data from existing studies and extrapolation from clinical trials in healthy women support the use of most contraceptive methods. This chapter will review contraception in women with type 1 (DM1) and type 2 (DM2) diabetes mellitus, with or without sequelae. It will also review contraception in prediabetic women, e.g., with previous gestational diabetes mellitus to augment the limited studies in women with DM2. The goal will be to provide a simple question-based approach to individualized counseling, considering diabetic sequelae and comorbidities, metabolic effects, and lifestyle demands.
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References
Clausen TD, Mathiesen E, Ekbom P, Hellmuth E, Mandrup-Poulsen T, Damm P. Poor pregnancy outcome in women with type 2 diabetes. Diabetes Care 28:323–328, 2005
Towner D, Kjos SL, Leung B, Montoro MM, Xiang A, Mestman JH, Buchanan TA. Congenital malformations in pregnancies complicated by NIDDM. Diabetes Care 18:1446–1451, 1995
Gilbert C, Valois M, Koren G. Pregnancy outcome after first trimester exposure to metformin: a meta-analysis. Fertil Steril 86:658–663, 2006
Piaggio G, Grimes DA, Van Look PFA. Task Force on Postovulatory Methods of Fertility Regulation Timing of emergency contraception with levonorgestrel or the Yuzpe regimen. Lancet 353:721, 1999
Spellacy WN, Buhi WC, Birk SA. The effect of estrogens on carbohydrate metabolism: glucose, insulin and growth hormone studies on one hundred seventy-one women ingesting premarin, mestranol and ethinyl estradiol for six months. Am J Obstet Gynecol 114:388–392, 1971
Perlman JA, Russell-Briefel R, Ezzati T, Lieberknecht. Oral glucose tolerance and the potency of contraceptive progestins. J Chronic Dis 338:857–864, 1985
Fahmy K, Abdel-Razik, Shaaraway M, et al. Effect of long-acting progestagen-only injectable contraceptives on carbohydrate metabolism and its hormonal profile. Contraception 44:419–429, 1991
Konje JC, Otolorin EO, Ladipo AO. The effect of continuous subdermal levonorgestrel (Norplant) on carbohydrate metabolism. Am J Obstet Gynecol 166(1 Pt 1):15–19, 1992
Wilson ES, Cruickshank J, McMaster M, et al. A prospective controlled study of the effect on blood pressure of contraceptive preparations containing different types of dosages and progestogen. Br J Obstet Gynaecol 91:1254–1260, 1984
Singh K, Viegas OA, Koh SC, Ratnam SS. The effect of long-term use of Norplant implants on haemostatic function. Contraception 45:141–153, 1992
Fajumi JO. Alterations in blood lipids and side effects induced by depo-provera in Nigerian women. Contraception 27:161–175, 1983
Shaaban MM, Elwan SI, Abdalla SA, Darwish HA. Effect of subdermal levonorgestrel contraceptive implants, Norplant, on serum lipids. Contraception 30:413–419, 1984
Meade TW. Oral contraceptives, clotting factors and thrombosis. Am J Obstet Gynecol 142:758–761, 1982
Shaaban M, Elwan SI, El-Kabsh MY, Farghaly SA, Thabet N. Effect of levonorgestrel contraceptive implants, Norplant, on blood coagulation. Contraception 30:421–430, 1984
Godsland IF, Crook D, Simpson R, et al. The effects of different formulations of oral contraceptive agents on lipid and carbohydrate metabolism. N Engl J Med 323:1375–1381, 1990
Liew DFM, Ng CSA, Yong YM, et al. Long term effects of depo-provera on carbohydrate and lipid metabolism. Contraception 31:51, 1985
Speroff L, DeCherney A. Evaluation of a new generation of oral contraceptives. The Advisory Board of the New Progestins. Obstet Gynecol 81:1034–1047, 1993
Fahraeus L, Sydsjo A, Wallentin L. Lipoprotein changes during treatment of pelvic endometriosis with medroxyprogesterone acetate. Fertil Steril 45:501–506, 1986
Deslypere JP, Thiery N, Vermeulen A. Effect of long-term hormonal contraception in plasma lipids. Contraception 31:633–642, 1985
Haiba NA, et al. Clinical evaluation of two monthly injectable contraceptives and their effects on some metabolic parameters. Contraception 39:619–632, 1989
Kesserü EV, et al. A multicentered, two-year, phase III clinical trial of norethisterone enanthate 50 mg plus estradiol valerate 5 mg as a monthly injectable contraceptive. Contraception 44:589–598, 1991
Smallwood GH, et al. Efficacy and safety of a transdermal contraceptive system. Obstet Gynecol 98:799–805, 2001
Visser J, Snel M, Van Vliet HAAM. Hormonal versus non-hormonal contraceptives in women with diabetes mellitus type 1 and 2 (review). The Cochrane Collaboration, http://www.thecochranelibrary.com., Issue 1, 2008
The World Health Organization Medical Eligibility Criteria for Contraceptive Use, 3rd edition 2004, http://www.who.int/reproductive-health
Dong W, Colhoun HM, Poulter NR. Blood pressure in women using oral contraceptives: results from the Health Survey for England 1994. J Hypertens 15:1063, 1997
Heimemann LA, Lewis MA, Thorogood M, et al. Case-control study of oral contraceptives and risk of thromboembolic stroke: results from International Study on Oral Contraceptives and Health of Young Women. BMJ 315:1502, 1997
Petitti DB, Sidney S, Bernstein A, et al. Stroke in users of low-dose oral contraceptives. N Engl J Med 335:8, 1996
Lidegaard O. Oral contraceptives, pregnancy and the risk of cerebral thromboembolism: the influence of diabetes, hypertension, migraine and previous thrombotic disease. Br J Obstet Gynaecol 102:153, 1995
Gillum LA, Mamidipudi SK, Johnston SC. Ischemic stroke risk with oral contraceptives: a meta-analysis. JAMA 284:72–78, 2000
Khader YS, et al. Oral contraceptives use and the risk of myocardial infarction: a meta-analysis. Contraception 68:11–17, 2003
Tanis BC, et al. Oral contraceptives and the risk of myocardial infarction. N Engl J Med 345:1787–1193, 2001
Collaborative Group for the Study of Stroke in Young Women. Oral contraceptives and stroke in young women: associated risk factors. JAMA 231:718, 1975
Lidegaard O. Oral contraceptives and risk of cerebral thromboembolic attack: Results of a case-control study. BMJ 306:956, 1993
WHO Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. Ischaemic stroke and combined oral contraceptives: results of an international, multicentre, case-control study. Lancet 348:498, 1996
Selber C, Babrouche E, Fagan J, Myint E, Wetterneck T, Wittemyer M. Prescribing oral contraceptives for women older than 35 years of age. Ann Intern Med 138:54–64, 2003
Skouby SO, Jensen BM, Kuhl C, et al. Hormonal contraception in diabetic women: acceptability and influence on diabetes control of a nonaldkylated estrogen/progestogen compound. Contraception 32:23–31, 1985
Skouby SO, Molsted-Pedersen, Kuhl C, et al. Oral contraceptives in diabetic women: metabolic effects of four compounds with different estrogen/progestogen profiles. Fertil Steril 46:858–864, 1986
Radberg T, Gustafson A, Skryten A, et al. Oral contraception in diabetic women. Diabetes control, serum and high density lipoprotein lipids during low-dose progestogen, combined oestrogen/progestogen and non-hormonal contraception. Acta Endocrinol 98:246–251, 1981
Peterson KR, Skouby SO, Sidelmann J, Molsted-Pedersen L, Jespersen J. Effects of contraceptive steroids on cardiovascular risk factors in women with insulin-dependent diabetes mellitus. Am J Obstet Gynecol 171:400–405, 1994
Peterson KR, Skouby SO, Vedel P, Haaber AB. Hormonal contraception in women with IDDM. Diabetes Care 18:800–806, 1995
Klein BEK, Moss SE, Klein R. Oral contraceptives in women with diabetes. Diabetes Care 13:895–898, 1990
Garg SK, Chase HP, Marshal G, Hoops S, Holmes DL, Jackson WE. Oral contraceptives and renal and retinal complications in young women with insulin-dependent diabetes mellitus. JAMA 271:1099–1102, 1994
Ahmed SB, Hovind P, Prving H-H, Rossing P, Price DA, Laffel LM, Lansang MC, Fisher NDL, Hollenberg NK. Oral contraceaptives, angiotensin-dependent renal vasoconstriction, and risk of diabeteic nephropathy. Diabetes Care 28:1988–1994, 2005
Skouby SO, Anderson O, Saurbrey N, et al. Oral contraception and insulin sensitivity: in vivo assessment in normal women and women with previous gestational diabetes. J Clin Endocrinol Metab 64:519–523, 1987
Skouby SO, Kuhl C, Molsted-Pedersen, et al. Triphasic oral contraception: metabolic effects in normal women and those with previous gestational diabetes. Am J Obstet Gynecol 153:495–500, 1985
Kjos SL, Shoupe D, Douyan S, et al. Effect of low-dose oral contraceptives on carbohydrate and lipid metabolism in women with recent gestational diabetes: results of a controlled, randomized, prospective study. Am J Obstet Gynecol 163:1822–1827, 1990
Kjos SL, Peters RK, Xiang A, Thomas D, Schaefer U, Buchanan TA. Contraception and the risk of type 2 diabetes mellitus in Latina women with prior gestational diabetes mellitus. JAMA 280:533–538, 1998
Chasan-Taber L, Willett WC, Manson JE, Spiegelman D, Hunter DJ, Curham G, et al. Prospective study of oral contraceptives and hypertension among women in the United States. Circulation 94:483–489, 1996
Xiang AH, Kawakubo M, Kjos SL, Buchanan TA. Long-acting injectable progestin contraception and risk of type 2 diabetes in Latino women with prior gestational diabetes mellitus. Diabetes Care 29(3):613–617, 2006
Farley TMM, Rosenberg MJ, Rowe PJ, Chen J-H, Meirek O. Intrauterine devices and pelvic inflammatory disease: an international perspective. Lancet 339:785–788, 1992
Skouby SO, Molsted-Pedersen L, Kosonen A. Consequences of intrauterine contraception in diabetic women. Fert Steril 42:568–572, 1984
Kimmerle R, Weiss R, Berger M, Kurz K-H. Effectiveness, safety and acceptablilty of a copper intrauterine device (CU Safe 300) in type I diabetic women. Diabetes Care 16:1227–1230, 1993
Kjos SL, Ballagh SA, La Cour M, Xiang A, Mishell DR Jr. The copper T380A intrauterine device in women with type II diabetes mellitus. Obstet Gynecol 84:1006–1009, 1994
Gosen C, Steel J, Ross A, Springerbett A. Intrauterine contraception in diabetic women. Lancet 1:530–535, 1982
Lawless M, Vessey MP. Intrauterine device use by diabetic women. Br J Fam Plann 7:110–111, 1982
Wiese J. Intrauterine contraception in diabetic women. Fert Steril 28:422–425, 1977
Stewart A, et al. The effectiveness of the levonorgestrel-releasing intrauterine systems in menorrhagia: a systemic review. BJOG 108:74–86, 2001
Rogovskay S, Rivera R, Grimes DA, Chen P-L, Bosny P-L, Prilepskaya V, Kulakov V. Effect of levonorgestrel intrauterine system on women with type 1 diabetes: a randomized trial. Obstet Gynecol 105:811–815, 2005
Campbell OM, Gray RH. Characteristics and determinants of postpartum ovarian function in women in the United States. Am J Obstet Gynecol 169:55–60 1993
Perez A, Labbok MH, Queenan JT. Clinical study of the lactational amenorrhoea method for family planning. Lancet 339:968–970, 1992
Kennedy KI, Rivera R, McNeilly AS. Consensus statement on the use of breastfeeding as a family planning method. Contraception 39:477–496, 1989
Labbok M, Perez A, Valdes V, et al. The lactational amenorrhea method (LAM): a postpartum introductory family planning method with policy and program implications. Adv Contracept 10:93–109, 1994
Quality Care in Family Planning. Medical Eligibility Criteria for Contraceptive Use. Geneva: World Health Organization Reproductive Health and Research, 2000
Truit ST, Fraser AB, Grimes DA, Gallo MF, Schulz KF. Combined hormonal versus nonhormonal versus progestin-only contraception in lactation. Cochrane Database Syst Rev (2):CDC003988, 2003
World Health Organization (WHO). Selected Practice Recommendations for Contraceptive Use. Geneva, Switzerland: WHO, 2002
Faculty of Family Planning and Reproductive Health Care Clinical Effectiveness Unit. Family Planning and Reproductive Health Care Guidance (July 2004). Contraceptive choices for breastfeeding women. J Fam Plann Reprod Health Care 30:181–189, 2004
ACOG Educational Bulletin No 258. Breastfeeding: Maternal and Infant Aspects. Washington DC: American College of Obstetricians and Gynecologists 2004 Compendium of Selected Publications, 2004
Zhou L, Xiao B. Emergency contraception with Multiload Cu-375 SL IUD: a multicenter clinical trial. Contraception 64:107–112, 2001
Stage E, Nøgård, Damm P, Mathiesen E. Long-term breast-feeding in women with type 1 diabetes. Diabetes Care 29:7714, 2006
Schaefer-Graf UM, Hartmann R, Pawliczik J, Passow D, About-Dakn M, Vetter K, Kordonouri O. Association of breast-feeding and early childhood overweight in children from mothers with gestational diabetes mellutis. Diabetes Care 29:1105–1107, 2006
Public Affairs Committee of Teratology Society. Teratology Public Affairs Committee Position Paper: maternal obesity and pregnancy. Birth Defects Res A Clin Mol Teratol 76:73–77, 2006
Stuebe AM, Rich-Edwards JW, Willett WC, Manson JE, Michels KB. Duration of lactation and incidence of type 2 diabetes. JAMA 294:2601–2610, 2005
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Kjos, S.L. (2009). Contraception for Women with Diabetes. In: Tsatsoulis, A., Wyckoff, J., Brown, F. (eds) Diabetes in Women. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-60327-250-6_9
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