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Platelets in Arterial Thrombosis

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Antithrombotic Drug Therapy in Cardiovascular Disease

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

The central role of the platelet in thrombus formation has been well established. Whereas thrombus formation in some situations may be protective, it can be devastating in others such as in acute coronary syndromes. An understanding of the mechanisms and the molecules involved in platelet-mediated thrombosis is essential in order to be able to devise antiplatelet regimens that may improve patient outcomes and to develop future generations of antithrombotic drugs. This chapter provides a brief summary of the molecules and mechanisms which regulate platelet adhesion and aggregation.

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Authors and Affiliations

  1. Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH, USA

    Edward F. Plow PHD

  2. Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA

    Peter Kelly MD

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  2. Peter Kelly MD
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Correspondence to Edward F. Plow PHD .

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  1. Western Reserve Heart Care, Corporate Dr. 1335, Hudson, 44236, U.S.A.

    Arman T. Askari

  2. Dept. Cardiovascular Medicine, Cleveland Clinic, Euclid Ave. 9500, Cleveland, 44195, U.S.A.

    A. Michael Lincoff

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Plow, E.F., Kelly, P. (2010). Platelets in Arterial Thrombosis. In: Askari, A., Lincoff, A. (eds) Antithrombotic Drug Therapy in Cardiovascular Disease. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-235-3_1

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