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Stem Cells, Hypoxia and Hypoxia-Inducible Factors

  • Chapter
Regulatory Networks in Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Oxygen is a critical environmental factor that regulates the fate of stem cells. In this review, our aims are twofold: (i) to consider the contribution of oxygen tension to the environmental niches in which stem cells and their progeny find themselves and which have a role in determining their fate, and (ii) to define the regulatory networks that control the response of stem/progenitor cells to hypoxia, particularly those that affect early embryonic stem cell specification and hematopoietic stem cell development and function.

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Authors and Affiliations

  1. Stem Cells and Immunotherapies, NHS Blood and Transplant, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK

    Suzanne M. Watt, Grigorios Tsaknakis, Sinead P. Forde & Lee Carpenter

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  1. Suzanne M. Watt
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  2. Grigorios Tsaknakis
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  3. Sinead P. Forde
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  4. Lee Carpenter
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Correspondence to Suzanne M. Watt .

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Editors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Vinagolu K. Rajasekhar MSc, MPhil, PhD

  2. Invitrogen Corporation, Frederick, MD, USA

    Mohan C. Vemuri Ph.D.

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC, a part of Springer Science+Business Media, LLC

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Watt, S.M., Tsaknakis, G., Forde, S.P., Carpenter, L. (2009). Stem Cells, Hypoxia and Hypoxia-Inducible Factors. In: Rajasekhar, V.K., Vemuri, M.C. (eds) Regulatory Networks in Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-60327-227-8_18

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