Skip to main content

Historical Perspective: A Century of Primary (Idiopathic) Pulmonary Hypertension

  • Chapter
Pulmonary Hypertension

Part of the book series: Contemporary Cardiology™ ((CONCARD))

  • 1635 Accesses

Abstract

During the past century, great progress has been made in the understanding of pulmonary hemodynamics and in the control of the normal and hypertensive pulmonary circulations. In large measure, the door to new knowledge was opened by the introduction and standardization of right heart catheterization in normal individuals and subsequently in patients with pulmonary hypertension. A byproduct of this remarkable progress has been the development of a classification schema for pulmonary hypertensive diseases based more on pathophysiology. Unfortunate experiments of nature giving rise to pulmonary hypertension epidemics related to appetite suppressant ingestion have nonetheless provided insights into its pathogenesis. The progress over the past century has laid the foundation for the gains in management that we have witnessed in recent years. In the near future, newer and less invasive technologies for detection and assessment, such as echocardiagraphic and magnetic resonance imaging, and novel, more effective medications are raising hopes for steadily improving outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Romberg E. Ueber Sklerose der Lungen arterie. Dsch Archiv Klin Med 1891; 48:197–206.

    Google Scholar 

  2. Larrabee WF., Parker RL., Edwards JE. Pathology of intrapulmonary arteries and arterioles in mitral stenosis. Proc Mayo Clin 1949; 24:316–326.

    Google Scholar 

  3. Mönckeberg JG. Ueber die genuine Arteriosklerose der Lungenarterie. D Med Wchnschr 1907; 33:1243–1246.

    Article  Google Scholar 

  4. Arrillaga FC. Sclérose de l’ artére pulmonaire (cardiagues noirs). Bull Mem Soc Méd Hop Paris 1924; 48:292–303.

    Google Scholar 

  5. Brachetto-Brian D. Concepto anatomo-pathologico de los cardiacos engross de Ayerza. Rev Soc Med Int Soc Tisiol 1925; 1:821–931.

    Google Scholar 

  6. Posselt, A. Zur Pathologie und Klinik der primären Atherosklerosis pulmonalis. Wien Arch £ Inn Med 1925; 11–357.

    Google Scholar 

  7. Brill IC., Krygier CK. Primary pulmonary vascular sclerosis. Arch Intern Med 1941; 68:560–577.

    Google Scholar 

  8. Brenner O. Pathology of the vessels of the pulmonary circulation. Arch Intern Med 1935; 56:211–237, 457–497, 724–752, 976–1014, 1190–1241.

    Google Scholar 

  9. Wiggers CJ. The Pressure Pulses in the Cardiovascular System. New York. Longmans. 1928.

    Google Scholar 

  10. Zuntz N., Hagemann O. Untersuchungen über den Stoffwechsel des Pferdes bei Ruhe und Arbeit. Landw. jahrb. XXVII Band, Ergänzungsband III, Paul Parey publisher, Berlin, 1898, pp. 1–438.

    Google Scholar 

  11. Frank O. Der Puls in den Arterien. Ztsch Biol 1905; 46:441–543.

    Google Scholar 

  12. Lategola M., Rahn H. A self-guiding catheter for cardiac and pulmonary arterial catheterization and occlusion. Proc Soc Exp Biol Med 1953; 84:667–668.

    PubMed  CAS  Google Scholar 

  13. Hellems HK., Haynes FW., Dexter L. Pulmonary “Capillary” Pressure in Man. J Appl Physiol 1949–1950; 2:24–29.

    CAS  Google Scholar 

  14. Swan HJ., Ganz W., Forrester J., Marcus H., Diamond G., Chonette D. Catheterization of the heart in man with use of a flow-directed balloon-tipped catheter. N Engl J Med 1970; 283(9):447–451.

    PubMed  CAS  Google Scholar 

  15. Krogh A., Lindhard J. Measurement of the blood flow through the lungs of man. Skand Arch Physiol 1912; 27:100–125.

    CAS  Google Scholar 

  16. Euler USV., Liljestrand G. Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 1946; 12:301–320.

    Article  Google Scholar 

  17. Cerretelli P., Cruz JC., Fahri LE., Rahn H. Determination of mixed venous O2 and CO2 tensions and cardiac output by a rebreathing method. Respir Physiol 1966; 1:258–264.

    Article  PubMed  CAS  Google Scholar 

  18. Liljestrand G. Regulation of pulmonary arterial blood pressure. Acta Physiol Scand 1947; 14:162–172.

    Google Scholar 

  19. Fick A. Uber die Messung des Blutquantums in den Herzventrikeln. Sitx der Physik-Med ges Wurzburg 1870; 16.

    Google Scholar 

  20. Motley HL., Cournand A., Werko L., Himmelstein A., Dresdale D. The influence of short periods of induced acute anoxia upon pulmonary arterial pressures in man. Am J Physiol 1947–1948; 150:315–320.

    Google Scholar 

  21. Forssmann W. Die Sondierung des rechten Herzens, Klin Wochnschr 1929; 8:2085–2087.

    Article  Google Scholar 

  22. Fishman AP. Respiratory gases in the regulation of the pulmonary circulation. Physiol Rev 1961; 41:214–279.

    PubMed  CAS  Google Scholar 

  23. Cournand A. Control of the Pulmonary Circulation in Normal Man. Proc. of the Harvey Tercentenery Congress. Oxford. Blackwell Scientific Publications. 1958; 219–237.

    Google Scholar 

  24. Dawes GS. Foetal and Neonatal Physiology: A Comparative Study of the Changes at Birth. Chicago, Yearbook Medical Publishers, 1968.

    Google Scholar 

  25. Wood P. Diseases of the Heart and Circulation. Philadelphia, J. B. Lippincott, 1952.

    Google Scholar 

  26. Dresdale DT., Michtom RF., Schultz M. Recent studies in primary pulmonary hypertension including pharmacodynamic observations on pulmonary vascular resistance. Bull NY Acad Med 1954; 30:195–207.

    CAS  Google Scholar 

  27. Harris P. Influence of acetylcholine on the pulmonary arterial pressure. Br Heart J 1957; 19(2):272–278.

    Article  PubMed  CAS  Google Scholar 

  28. Fritts HW., Harris P. Jr., Clauss RH., Odell JE., Cournand A. The effect of acetylcholine on the human pulmonary circulation under normal and hypoxic conditions. J Clin Invest 1958; 37:99–108.

    Article  PubMed  Google Scholar 

  29. Wood P., Besterman EM. Towers MK., McIlroy, MB. The effect of acetyleholine on pulmonary vascular resistance and left atrial pressure in mitral stenosis. Br Heart J 1957; 19(2):279–286.

    Article  PubMed  CAS  Google Scholar 

  30. Gurtner HP. Aminorex pulmonary hypertension. In: Fishman AP., ed. The Pulmonary Circulation: Normal and Abnormal. Mechanisms, Management and the National Registry. Philadelphia. University of Pennsylvania Press. 1990; 397–411.

    Google Scholar 

  31. Hatano S., Strasser R. eds. Primary pulmonary hypertension. World Heath Organization, Geneva, 1975.

    Google Scholar 

  32. Fishman, AP. Introduction to the national registry on primary pulmonary hypertension. In: Fishman, AP., ed. The Pulmonary Circulation: Normal and Abnormal. Philadelphia. University of Pennsylvania Press. 1990; 437–439.

    Google Scholar 

  33. Pietra, GG. The histopathology of primary pulmonary hypertension. In: Fishman, AP., ed. The Pulmonary Circulation: Normal and Abnormal. Philadelphia. University of Pennslvania Press. 1990; 459–472.

    Google Scholar 

  34. Wagenvoort, CA. Pathology of Pulmonary Hypertension. New York. John Wiley and Sons. 1977; 217–231.

    Google Scholar 

  35. Abenhaim L., Moride Y., Brenot F et al. Appetite-Suppressant drugs and the risk of primary pulmonary hypertension. N Engl J Med 1996; 335:609–616.

    Article  PubMed  CAS  Google Scholar 

  36. Loyd JE., Newman J. Familial primary pulmonary hypertension: clinical patterns. Am Rev Resp Dis 1984; 129:194–197.

    PubMed  CAS  Google Scholar 

  37. Newman JH., Lane KB. Hypertensive pulmonary vascular disease: dawn of the age of prevention? Am J Respir Crit Care Med 2000; 162(6):2020–2021.

    PubMed  CAS  Google Scholar 

  38. Newman JH., Trembath RC., Morse JA., Grunig E., Loyd JE., Adnot S., Coccolo F., Ventura C., Phillips JA 3rd, Knowles JA., Janssen B., Eickelberg O., Eddahibi S., Herve P., Nichols WC., Elliott G. Genetic basis of pulmonary arterial hypertension: current understanding and future directions. J Am Coll Cardiol 2004; 43(12 Suppl S):33S–39S.

    Article  PubMed  CAS  Google Scholar 

  39. Trembath RC., Thomson JR., Machado RD., Morgan NV., Atkinson C., Winship I., Simonneau G., Galie N., Loyd JE., Humbert M., Nichols WC., Morrell NW., Berg J., Manes A., McGaughran J., Pauciulo M., Wheeler L. Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia. N Engl J Med 2001; 345(5):325–334.

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Humana Press, Totowa, NJ

About this chapter

Cite this chapter

Fishman, A.P. (2008). Historical Perspective: A Century of Primary (Idiopathic) Pulmonary Hypertension. In: Hill, N.S., Farber, H.W. (eds) Pulmonary Hypertension. Contemporary Cardiology™. Humana Press. https://doi.org/10.1007/978-1-60327-075-5_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-075-5_1

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-661-0

  • Online ISBN: 978-1-60327-075-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics