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Bone Morphogenic Proteins and Angiogenesis in Developing Tumors

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Transforming Growth Factor-β in Cancer Therapy, Volume I

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Bone Morphogenetic Proteins (BMPs) are multipurpose cytokines that act in both a paracrine and self-autonomous manner. BMP-2 was originally identified for its ability to induce bone formation. BMP-2 and BMP-4 have also been shown to have a critical role in the regulation of stem cells promoting their self-renewal and differentiation. More recently, BMP-2 was demonstrated to be aberrantly expressed in lung and other carcinomas. Studies have suggested that BMP-2 has an important role in cancer biology promoting tumor invasion and metastasis. One essential mechanism may be its ability to induce a neovasculature in tumors. This work reviews the literature that high-lights the role of BMPs inducing angiogenesis in tumors.

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Authors and Affiliations

  1. Department of Surgery, Division of Thoracic Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA

    George Berberian PhD, Deepak Malhotra MD & John E. Langenfeld MD

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  1. George Berberian PhD
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  2. Deepak Malhotra MD
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  3. John E. Langenfeld MD
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© 2008 Humana Press

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Berberian, G., Malhotra, D., Langenfeld, J.E. (2008). Bone Morphogenic Proteins and Angiogenesis in Developing Tumors. In: Transforming Growth Factor-β in Cancer Therapy, Volume I. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-292-2_23

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  • DOI: https://doi.org/10.1007/978-1-59745-292-2_23

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-714-3

  • Online ISBN: 978-1-59745-292-2

  • eBook Packages: MedicineMedicine (R0)

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