Summary
The metabotropic glutamate (mGlu) receptors are a family of eight G protein-coupled receptors that modulate cell excitability and synaptic transmission in the nervous system. Group I mGlu receptors are generally coupled to Gq stimulation of phospholipase C and the release of intracellular calcium. The physiologic effects of group I mGlu receptors in the brain are diverse and highlight the importance of these receptors in normal brain function. This chapter describes what is known about the structure, signaling, regulation, and function of the group I mGlu receptors in the nervous system, as well as the roles of these receptors in disease. It also discusses emerging roles in both central and peripheral nonneural tissues. Because the group I mGlu receptors modulate rather than mediate excitatory neurotransmission, they are exciting targets for new therapeutic strategies. However, further understanding of the complex regulatory mechanisms associated with these receptors is required to design more beneficial therapies for neurodegenerative and neuropsychiatric disorders.
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Saugstad, J.A., Ingram, S.L. (2008). Group I Metabotropic Glutamate Receptors (mGlu1 and mGlu5). In: Gereau, R.W., Swanson, G.T. (eds) The Glutamate Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-59745-055-3_10
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