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Thrombospondin

Guarding the Clear View

  • Chapter
Ocular Angiogenesis

Part of the book series: Opthalmology Research ((OPHRES))

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Abstract

A itnumber of isolated studies clearly point to the contribution of thrombospondin-1 and related proteins to the regulation of angiogenesis in disparate eye compartments. Surprisingly there has been no attempt to systematically review this information and to summarize these proteins’ role in ocular angiogenesis. The goal of this chapter is to provide a unified view of their function as a part of complex defense mechanism protecting vascular stasis in the eye.

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Authors and Affiliations

  1. Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Arin Aurora & Olga V. Volpert PhD

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  1. Arin Aurora
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  1. Division of Pharmaceutical Sciences, University of Missouri-Kansas City, Kansas City, MO

    Joyce Tombrain-Tink PhD

  2. Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT

    Joyce Tombrain-Tink PhD  & Colin J. Barnstable DPhil  & 

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Aurora, A., Volpert, O.V. (2006). Thrombospondin. In: Tombrain-Tink, J., Barnstable, C.J. (eds) Ocular Angiogenesis. Opthalmology Research. Humana Press. https://doi.org/10.1007/978-1-59745-047-8_14

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  • DOI: https://doi.org/10.1007/978-1-59745-047-8_14

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