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Postpartum Depression

A Common Complication of Childbirth

  • Chapter
Psychiatric Disorders in Pregnancy and the Postpartum

Part of the book series: Current Clinical Practice ((CCP))

Abstract

Postpartum depression (PPD) or, simply, postpartum are the most commonly used lay terms for describing major depressive disorder occurring in the postnatal period. Whether the disorder occurs de novo, is a relapse of a previous depressive episode, or has its origin in the antepartum period, depression after childbirth is associated with significant maternal and infant morbidity and, in worst cases, mortality. With most epidemiological studies demonstrating a prevalence of 10–13%, PPD is one of the most common complications of childbirth (1,2). Yet, the pathogenesis, natural history, and treatment of the disorder have been shrouded in mystery and myth as society and science has imbued motherhood with a cloak of sanctity that cuts both ways. Attempts to protect mothers and their offspring from unnecessary intrusions or potential harm have unwittingly limited detection of PPD in the clinical setting and the investigation of its pathogenesis and treatment in the scientific arena. p] Thus, PPD continues to be a major public health problem, with more than 400,000 women in the United States alone suffering each year from this potentially devastating disease. The overarching purpose of this chapter is to review the studies that provide the most rigorous and up-to-date findings regarding the detection, pathogenesis, and treatment of depression occurring in the postnatal period. In doing so, this chapter will enable the primary care provider to become more comfortable in assessing postpartum women and treating those who, in many cases, would otherwise go without care.

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References

  1. Epperson, C. N. (1999) Postpartum major depression: detection and treatment. Am. Fam. Physician 59, 2247–2254, 2259-2260.

    PubMed  CAS  Google Scholar 

  2. O’Hara, M. W., Neunaber, D. J., and Zekoski, E. M. (1984) Prospective study of postpartum depression: prevalence, course, and predictive factors. J. Abnorm. Psychol. 93, 158–171.

    PubMed  CAS  Google Scholar 

  3. Cox, J. L., Holden, J. M., and Sagovsky, R. (1987) Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. Br. J. Psychiatry 150, 782–786.

    PubMed  CAS  Google Scholar 

  4. Peindl, K. S., Wisner, K. L., and Hanusa, B. H. (2004) Identifying depression in the first postpartum year: guidelines for office-based screening and referral. J. Affect. Disord. 80, 37–44.

    PubMed  Google Scholar 

  5. Glasser, S., Barell, V., Boyko, V., et al. (2000) Postpartum depression in an Israeli cohort: demographic, psychosocial and medical risk factors. J. Psychosom. Obstet. Gynecol. 21, 99–108.

    CAS  Google Scholar 

  6. Wickberg, B. and Hwang, C. P. (1996) The Edinburgh Postnatal Depression Scale: validation on a Swedish community sample. Acta Psychiatr. Scand. 94, 181–184.

    PubMed  CAS  Google Scholar 

  7. Beck, C. T. and Gable, R. K. (2000) Postpartum depression screening scale: development and psychometric testing. Nurs. Res. 49, 272–282.

    PubMed  CAS  Google Scholar 

  8. Beck, C. T. and Gable, R. K. (2001) Comparative analysis of the performance of the Postpartum Depression Screening Scale with two other depression instruments. Nurs. Res. 50, 242–250.

    PubMed  CAS  Google Scholar 

  9. Spitzer, R. L., Williams, J. B., Kroenke, K., et al. (1994) Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study. JAMA 272, 1749–1756.

    PubMed  CAS  Google Scholar 

  10. Spitzer, R. L., Williams, J. B., Kroenke, K., et al. (2000) Validity and utility of the PRIME-MD patient health questionnaire in assessment of 3000 obstetric-gynecologic patients: the PRIME-MD Patient Health Questionnaire Obstetrics-Gynecology Study. Am. J. Obstet. Gynecol. 183, 759–769.

    PubMed  CAS  Google Scholar 

  11. Gerstein, H. C. (1990) How common is postpartum thyroiditis? A methodologic overview of the literature. Arch. Intern. Med. 150, 1397–400.

    PubMed  CAS  Google Scholar 

  12. Kokandi, A. A., Parkes, A. B., Premawardhana, L. D., et al. (2003) Association of postpartum thyroid dysfunction with antepartum hormonal and immunological changes. J. Clin. Endocrinol. Metab. 88, 1126–1132.

    PubMed  CAS  Google Scholar 

  13. Lazarus, J. H. Thyroid dysfunction: reproduction and postpartum thyroiditis. (2002) Semin. Reprod. Med. 20, 381–388.

    PubMed  Google Scholar 

  14. Muller, A. F., Drexhage, H. A., and Berghout, A. (2001) Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care. Endocr. Rev. 22, 605–630.

    PubMed  CAS  Google Scholar 

  15. Oretti, R.G., Harris, B., Lazarus, J. H., et al. (2003) Is there an association between life events, postnatal depression and thyroid dysfunction in thyroid antibody positive women? Int. J. Soc. Psychiatry 49, 70–76.

    PubMed  Google Scholar 

  16. Harris, B., Oretti, R., Lazarus, J., et al. (2002) Randomised trial of thyroxine to prevent postnatal depression in thyroid-antibody-positive women. Br. J. Psychiatry 180, 327–330.

    PubMed  Google Scholar 

  17. Kuijpens, J. L., Vader, H. L., Drexhage, H. A., et al. (2001) Thyroid peroxidase antibodies during gestation are a marker for subsequent depression postpartum. Eur. J. Endocrinol. 145, 579–584.

    PubMed  CAS  Google Scholar 

  18. Hendrick, V., Altshuler, L., and Whybrow, P. (1998) Psychoneuroendocrinology of mood disorders. The hypothalamic-pituitary-thyroid axis. Psychiatr. Clin. North Am. 21, 277–292.

    PubMed  CAS  Google Scholar 

  19. O’Hara, M..W., Zekoski, E.M., Philipps, L. H., and Wright, E. J. (1990) Controlled prospective study of postpartum mood disorders: comparison of childbearing and nonchildbearing women. J. Abnorm. Psychol. 99, 3–15.

    PubMed  CAS  Google Scholar 

  20. Stein, G. (1982) The maternity blues. In: Brockington, I. F. and Kumar, R.,eds. Motherhood and Mental Illness. New York: Grune and Stratton, pp. 119–154.

    Google Scholar 

  21. Handley, S. L., Dunn, T. L., Waldron, G., et al. (1980) Tryptophan, cortisol and puerperal mood. Br. J. Psychiatry 136, 498–508.

    PubMed  CAS  Google Scholar 

  22. Hannah, P., Adams, D., Lee, A., et al. (1992) Links between early post-partum mood and post-natal depression. Br. J. Psychiatry 160, 777–780.

    PubMed  CAS  Google Scholar 

  23. Cox, J. L., Connor, Y. M., Henderson, I., et al. (1983) Prospective study of the psychiatric disorders of childbirth by self report questionnaire. J. Affect. Disord. 5, 1–7.

    PubMed  CAS  Google Scholar 

  24. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV). (1994) Washington, DC: American Psychiatric Association.

    Google Scholar 

  25. Wisner, K. L., Peindl, K., and Hanusa, B. H. (1994) Symptomatology of affective and psychotic illnesses related to childbearing. J. Affect. Disord. 30, 77–87.

    PubMed  CAS  Google Scholar 

  26. Brockington, I. F., Cernik, K. F., Schofield, E. M., et al. (1981) Puerperal psychosis. Phenomena and diagnosis. Arch. Gen. Psychiatry 38, 829–833.

    PubMed  CAS  Google Scholar 

  27. Wisner, K L., Peindl, K. S., Gigliotti, T., et al. (1999) Obsessions and compulsions in women with postpartum depression. J. Clin. Psychiatry 60, 176–180.

    PubMed  CAS  Google Scholar 

  28. Stanton, J., Simpson, A., and Wouldes, T. (2000) A qualitative study of filicide by mentally ill mothers. Child Abuse Neglect 24, 1451–1460.

    PubMed  CAS  Google Scholar 

  29. Chandra, P. S., Venkatasubramanian, G., and Thomas, T. (2002) Infanticidal ideas and infanticidal behavior in Indian women with severe postpartum psychiatric disorders. J. Nerv. Ment. Dis. 190, 457–461.

    PubMed  Google Scholar 

  30. Jennings, K. D., Ross, S., Popper, S., et al. (1999) Thoughts of harming infants in depressed and nondepressed mothers. J. Affect. Disord. 54(1-2), 21–28.

    Google Scholar 

  31. O’Hara, M. W., Schlechte, J. A., Lewis, D. A., et al. (1991) Prospective study of postpartum blues. Biologic and psychosocial factors. Arch. Gen. Psychiatry 48, 801–806.

    PubMed  CAS  Google Scholar 

  32. Sugawara, M., Toda, M. A., Shima, S., et al. (1997) Premenstrual mood changes and maternal mental health in pregnancy and the postpartum period. J. Clin. Psychol. 53, 225–232.

    PubMed  CAS  Google Scholar 

  33. Campbell, J. C., Poland, M. L., Waller, J. B., et al. (1992) Correlates of battering during pregnancy. Res. Nurs. Health 15, 219–226.

    PubMed  CAS  Google Scholar 

  34. Cox, J. L. (1982) Medical management, culture, and mental illness. Br. J. Hosp. Med. 27, 533–537.

    PubMed  CAS  Google Scholar 

  35. O’Hara, M. W. (1986) Social support, life events, and depression during pregnancy and the puerperium. Arch. Gen. Psychiatry 43, 569–573.

    PubMed  CAS  Google Scholar 

  36. O’Hara, M. W., Rehm, L. P., and Campbell S. B. (1983) Postpartum depression. A role for social network and life stress variables. J. Nerv. Ment. Dis. 171, 336–341.

    PubMed  CAS  Google Scholar 

  37. Paykel, E. S., Emms, E. M., Fletcher, J., et al. (1980) Life events and social support in puerperal depression. Br. J. Psychiatry 136, 339–346.

    PubMed  CAS  Google Scholar 

  38. Kendell, R.E. (1985) Emotional and physical factors in the genesis of puerperal mental disorders. J. Psychosom. Res. 29, 3–11.

    PubMed  CAS  Google Scholar 

  39. Turton, P., Hughes, P., Evans, C. D. H., et al. (2001). Incidence, correlates and predictors of post-traumatic stress disorder in the pregnancy after stillbirth. Br. J. Psychiatry 178, 556–560.

    PubMed  CAS  Google Scholar 

  40. O’Hara, M. W., Rehm, L. P., and Campbell, S. B. (1982) Predicting depressive symptomatology: cognitive-behavioral models and postpartum depression. J. Abnorm. Psychol. 91, 457–461.

    PubMed  CAS  Google Scholar 

  41. Playfair, H. R. and Gowers, J. I. (1981) Depression following childbirth-a search for predictive signs. J. Roy. Coll. Gen. Pract. 31, 201–208.

    CAS  Google Scholar 

  42. Alder, E. M. and Cox, J. L. (1983) Breast feeding and post-natal depression. J. Psychosom. Res. 27, 139–144.

    PubMed  CAS  Google Scholar 

  43. Parry, B. L., Sorenson, D. L., Meliska, C. J., et al. (2003) Hormonal basis of mood and postpartum disorders. Curr. Women’s Health Rep. 3, 230–235.

    Google Scholar 

  44. Bloch, M., Schmidt, P. J., Danaceau, M., et al. (2000) Effects of gonadal steroids in women with a history of postpartum depression. Am. J. Psychiatry 157, 924–930.

    PubMed  CAS  Google Scholar 

  45. Wieck, A., Kumar, R., Hirst, A. D., et al. (1991) Increased sensitivity of dopamine receptors and recurrence of affective psychosis after childbirth. Br. Med. J. 303(6803), 613–616.

    Google Scholar 

  46. Ahokas, A. and Aito, M. (1990) Role of estradiolin puerperal psychosis.Psychopharmacology 147, 108–110.

    Google Scholar 

  47. Ahokas, A., Aito, M., and Rimon, R. (2000) Positive treatment effect of estradiol in postpartum psychosis: a pilot study. J. Clin. Psychiatry 61, 166–169.

    PubMed  CAS  Google Scholar 

  48. Ahokas, A., Kaukoranta, J., Wahlbeck, K., et al. (2001) Estrogen deficiency in severe postpartum depression: successful treatment with sublingual physiologic 17beta-estradiol: a preliminary study. J. Clin. Psychiatry 62, 332–336.

    PubMed  CAS  Google Scholar 

  49. Ross L. E., Sellers E. M., Gilber Evans, S. E., et al. (2004) Mood changes during pregnancy and the postpartum period: development of a biopsychosocial model. Acta Psychiatr. Scand. 109, 457–466.

    PubMed  CAS  Google Scholar 

  50. Lawrie T. A., Hofmeyr G. J., De Jager, M., et al. (1998) A double-blind randomised placebo controlled trial of postnatal norethisterone enanthate: the effect on postnatal depression and serum hormones. Br. J. Obstet. Gynaecol. 105, 1082–1090.

    PubMed  CAS  Google Scholar 

  51. Butler, J. and Leonard, B. E. (1986) Post-partum depression and the effect of nomifensine treatment. Int. Clin. Psychopharmacol. 1, 244–252.

    PubMed  CAS  Google Scholar 

  52. Ballinger, C. B., Kay, D. S., Naylor, G. J., et al. (1982) Some biochemical findings during pregnancy and after delivery in relation to mood change. Psychol. Med. 12, 549–556.

    PubMed  CAS  Google Scholar 

  53. Heidrich, A., Schleyer, M., Spingler, H., et al. (1994) Postpartum blues: relationship between not-protein bound steroid hormones in plasma and postpartum mood changes. J. Affect. Disord. 30, 93–98.

    PubMed  CAS  Google Scholar 

  54. Harris, B., Johns, S., Fung, H., et al. (1989) The hormonal environment of postnatal depression. Br. J. Psychiatry 154, 660–667.

    PubMed  CAS  Google Scholar 

  55. Harris, B., Lovett, L., Newcombe, R. G., et al. (1994) Maternity blues and major endocrine changes: Cardiff puerperal mood and hormone study II. Br. Med. J. 308, 949–953.

    CAS  Google Scholar 

  56. Nott, P.N., Franklin, M., Armitage, C, et al. (1976) Hormonal changes and mood in the puerperium. Br. J. Psychiatry 128, 379–383.

    PubMed  CAS  Google Scholar 

  57. Singh, B., Gilhotra, M., Smith, R, et al. (1986) Post-partum psychoses and the dexamethasone suppression test. J. Affect. Disord. 11, 173–177.

    PubMed  CAS  Google Scholar 

  58. Harris, B., Lovett, L., Smith, J., et al. (1996) Cardiff puerperal mood and hormone study. III. Postnatal depression at 5 to 6 weeks postpartum, and its hormonal correlates across the peripartum period. Br. J. Psychiatry 168, 739–744.

    PubMed  CAS  Google Scholar 

  59. Magiakou, M. A., Mastorakos, G., Rabin, D., et al. (1996) Hypothalamic corticotropin-releasing hormone suppression during the postpartum period: implications for the increase in psychiatric manifestations at this time. J. Clin. Endocrinol. Metab. 81, 1912–1917.

    PubMed  CAS  Google Scholar 

  60. Stewart, D. E., Addison, A. M., Robinson, G. E., et al. (1988) Thyroid function in psychosis following childbirth. Am. J. Psychiatry 145, 1579–1581.

    PubMed  CAS  Google Scholar 

  61. Bokhari, R., Bhatara, V. S., Bandettini, F., et al. (1998) Postpartum psychosis and postpartum thyroiditis. Psychoneuroendocrinology 23, 643–650.

    PubMed  CAS  Google Scholar 

  62. Smith, J. E. (1990) Pregnancy complicated by thyroid disease. J. Nurse-Midwifery 35, 143–149.

    PubMed  CAS  Google Scholar 

  63. Glover, V., Liddle, P., Taylor, A., et al. (1994) Mild hypomania (the highs) can be a feature of the first postpartum week. Association with later depression. Br. J. Psychiatry 164, 517–521.

    PubMed  CAS  Google Scholar 

  64. Harris, B. Oretti, R., Lazarus, J., et al. (2002) Randomised trial of thyroxine to prevent postnatal depression in thyroid-antibody-positive women. Br. J. Psychiatry 180, 327–330.

    PubMed  Google Scholar 

  65. Epperson, C. N., Haga, K., Mason, G. F., et al. (2002) Cortical gammaaminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study. Arch. Gen. Psychiatry 59, 851–858.

    PubMed  CAS  Google Scholar 

  66. Epperson, C. N., Jatlow, P. I., Czarkowski, K., et al. (2003) Maternal fluoxetine treatment in the postpartum period: effects on platelet serotonin and plasma drug levels in breast-feeding mother-infant pairs. Pediatrics 112, e425.

    PubMed  Google Scholar 

  67. Demarest, K. T., Riegle, G. D., and Moore, K. E. (1984) Adenohypophysialdopamine content during physiological changes in prolactin secretion. Endocrinology 115, 2091–2097.

    PubMed  CAS  Google Scholar 

  68. Van Hartesveldt, C. and Joyce, J. N. (1986) Effects of estrogen on the basal ganglia. Neurosci. Biobehav. Rev. 10, 1–14.

    PubMed  Google Scholar 

  69. Wieck, A. (1989) Endocrine aspects of postnatal mental disorders. Baillieres Clin. Obstet. Gynaecol. 3, 857–877.

    PubMed  CAS  Google Scholar 

  70. Ettigi, P., Lal, S., Martin, J. B, et al. (1975) Effect of sex, oral contraceptives, and glucose loading on apomorphine-induced growth hormone secretion. J. Clin. Endocrinol. Metab. 40, 1094–1098.

    PubMed  CAS  Google Scholar 

  71. Cookson, J. C. (1985) The neuroendocrinology of mania. J. Affect. Disord. 233–241.

    Google Scholar 

  72. O’Hara, M. W., Schlechte, J. A., Lewis D. A., et al. (1991) Controlled prospective study of postpartum mood disorders: psychological, environmental, and hormonal variables. J. Abnorm. Psychol. 100, 63–73.

    PubMed  CAS  Google Scholar 

  73. Pedersen, C. A., Stern, R. A., Pate, J., et al. (1993) Thyroid and adrenal measures during late pregnancy and the puerperium in women who have been major depressed or who become dysphoric postpartum. J. Affect. Disord. 29(2-3), 201–211.

    Google Scholar 

  74. Ryan, A. S., Pratt, W. F., Wysong, J. L., et al. (1991) A comparison of breastfeeding data from the National Surveys of Family Growth and the Ross Laboratories Mothers Surveys. Am. J. Public Health 81, 1049–1052.

    PubMed  CAS  Google Scholar 

  75. Anonymous. (1997) Breast-feeding and the use of human milk. American Academy of Pediatrics work group on breast-feeding. Pediatrics 100, 1035–1039.

    Google Scholar 

  76. Wright, A. L., Holberg, C. J., Martinez, F. D., et al. (1989) Breast feeding and lower respiratory tract illness in the first year of life. Group Health Medical Associates. Br. Med. J. 299, 946–949.

    CAS  Google Scholar 

  77. Pisacane, A., Graziano, L., Mazzarella, G., et al. (1992) Breast-feeding and urinary tract infection. J. Pediatr. 120, 87–89.

    PubMed  CAS  Google Scholar 

  78. Aniansson, G., Alm, B., Andersson, B., et al. (1994) A prospective cohort study on breast-feeding and otitis media in Swedish infants. Pediatr. Infect. Dis. J. 13, 183–188.

    PubMed  CAS  Google Scholar 

  79. Takala, A. K. (1989) Epidemiologic characteristics and risk factors for invasive Haemophilus influenzae type b disease in a population with high vaccine efficacy. Pediatr. Infect. Dis. J. 8, 343–346.

    PubMed  CAS  Google Scholar 

  80. Halken, S., Host, A., Hansen, L. G., et al. (1992) Effect of an allergy prevention programme on incidence of atopic symptoms in infancy. A prospective study of 159 &quote;high-risk&quote; infants. Allergy 47, 545–553.

    PubMed  CAS  Google Scholar 

  81. Ford, R. P., Taylor, B. J., Mitchell, E. A., et al. (1993) Breast-feeding and the risk of sudden infant death syndrome. Int. J. Epidemiol. 22, 885–890.

    PubMed  CAS  Google Scholar 

  82. Mayer, E., Hamman, R., Gay, E., et al. (1988) Reduced risk of IDDM among breastfed children. Diabetes 37, 1625–1632.

    PubMed  CAS  Google Scholar 

  83. Fergusson, D. M., Beautrais, A. L., and Silva, P. A. (1982) Breast-feeding and cognitive development in the first seven years of life. Soc. Sci. Med. 16, 1705–1708.

    PubMed  CAS  Google Scholar 

  84. Lucas, A., Morley, R., Cole, T., et al. (1992) Breast milk and subsequent intelligence quotient in children born preterm. Lancet 339, 261–264.

    PubMed  CAS  Google Scholar 

  85. Vestergaard, M., Obel, C., Henriksen, T., et al. (1999) Duration of breast-feeding and developmental milestones during the latter half of infancy. ActaPaediatr. 88, 1327–1332.

    CAS  Google Scholar 

  86. Winans, E. A. (2001) Antipsychotics and breast-feeding. J. Hum. Lactation 17, 344–347.

    CAS  Google Scholar 

  87. Craig, M. and Abel, K. (2001) Drugs in pregnancy. Prescribing for psychiatric disorders in pregnancy and lactation. Best Pract. Res. Clin. Obstet. Gynaecol. 15, 1013–1030.

    PubMed  CAS  Google Scholar 

  88. Buist, A. (2001) Treating mental illness in lactating women. Medscape Womens Health 6, 3.

    PubMed  CAS  Google Scholar 

  89. Spencer, J. P., Gonzalez, L. S., 3rd., and Barnhart, D. J. (2001) Medications in the breast-feeding mother. Am. Fam. Physician 64, 119–126.

    Google Scholar 

  90. Burt, V. K., Suri, R., Altshuler, L. L., et al. (2001) The use of psychotropic medications during breast-feeding. Am. J. Psychiatry 158, 1001–1009.

    PubMed  CAS  Google Scholar 

  91. Dodd, S., Maguire, K. P., Burrows, G. D., et al. (2000) Nefazodone in the breast milk of nursing mothers: a report of two patients. J. Clin. Psychopharmacol. 20, 717–718.

    PubMed  CAS  Google Scholar 

  92. Tenyi, T., Csabi, G., and Trixler, M. (2000) Antipsychotics and breast-feeding: a review of the literature. Paediatr. Drugs 2, 23–28.

    PubMed  CAS  Google Scholar 

  93. Ito, S. (2000) Drug therapy for breast-feeding women. N. Engl. J. Med. 343, 118–126.

    PubMed  CAS  Google Scholar 

  94. Briggs, G., Freeman, R. K., and Yaffe, S. J., eds. (2002) Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 6th ed. Baltimore: Williams and Wilkins.

    Google Scholar 

  95. Stowe, Z. N., Owens, M. J., Landry, J. C, et al. (1997) Sertraline and desmethylsertraline in human breast milk and nursing infants [see comment]. Am. J. Psychiatry 154, 1255–1260.

    PubMed  CAS  Google Scholar 

  96. Stowe, Z. N., Cohen, L. S., Hostetter, A., et al. (2000) Paroxetine in human breast milk and nursing infants. Am. J. Psychiatry 157, 185–189.

    PubMed  CAS  Google Scholar 

  97. Hendrick, V., Stowe, Z. N., Altshuler, L. L., et al. (2001) Fluoxetine and norfluoxetine concentrations in nursing infants and breast milk. Biol. Psychiatry 50, 775–782.

    PubMed  CAS  Google Scholar 

  98. Dodd, S., Stocky, A., Buist, A., Burrows, G.D.,and Norman, T.R. (2001) Sertraline analysis in the plasma of breast-fed infants. Australian & New Zealand J. Psych. 35(4), 545–546.

    Google Scholar 

  99. Weissman, A. M., Barcey, T. L., Hartz, A. J., et al. (2004) Pooled analysis of antidepressant levels in lactating mothers, breast milk and nursing infants. Am. J. Psychiatry 161, 1066–1078.

    PubMed  Google Scholar 

  100. Hendrick, V., Fukuchi, A., Altshuler, L., et al. (2001) Use of sertraline, paroxetine and fluvoxamine by nursing women. Br. J. Psychiatry 179, 163–166.

    PubMed  CAS  Google Scholar 

  101. Dodd, S., Buist, A., and Norman, T. R. (2000) Antidepressants and breast-feeding: a review of the literature. Paediatr. Drugs 2, 183–192.

    PubMed  CAS  Google Scholar 

  102. Frey, O. R., Scheidt, P., and von Brenndorff, A. I. (1999) Adverse effects in a newborn infant breast-fed by a mother treated with doxepin. Ann. Pharmacother. 33, 690–693.

    PubMed  CAS  Google Scholar 

  103. Ilett, K. F., Hackett, L. P., Dusci, L. J., et al. (1998) Distribution and excretion of venlafaxine and O-desmethylvenlafaxine in human milk. Br. J. Clin. Pharmacol. 45, 459–462.

    PubMed  CAS  Google Scholar 

  104. Yoshida, K., Smith, B., and Kumar, R. C. (1997) Fluvoxamine in breast-milk and infant development. Br. J. Clin. Pharmacol. 44, 210–211.

    PubMed  CAS  Google Scholar 

  105. Epperson, C. N., Anderson, G. M., and McDougle, C. J. (1997) Sertraline and breast-feeding. N. Engl. J. Med. 336, 1189–1190.

    CAS  Google Scholar 

  106. Wisner, K. L. and Perel, J. M. (1996) Nortriptyline treatment of breast-feeding women. Am. J. Psychiatry 153, 295.

    PubMed  CAS  Google Scholar 

  107. Breyer-Pfaff, U., Nill, K., Entenmann K. N., et al. (1995) Secretion of amitriptyline and metabolites into breast milk. Am. J. Psychiatry 152, 812–813.

    PubMed  CAS  Google Scholar 

  108. Wisner, K. L., Perel, J. M., and Foglia, J. P. (1995) Serum clomipramine and metabolite levels in four nursing mother-infant pairs. J. Clin. Psychiatry 56, 17–20.

    PubMed  CAS  Google Scholar 

  109. Buist, A., Norman, T. R., and Dennerstein, L. (1993) Mianserin in breast milk. Br. J. Clin. Pharmacol. 36, 133–134.

    PubMed  CAS  Google Scholar 

  110. Wisner, K. L. and Perel J. M. (1991) Serum nortriptyline levels in nursing mothers and their infants. Am. J. Psychiatry 148, 1234–1236.

    PubMed  CAS  Google Scholar 

  111. Isenberg, K. E. (1990) Excretion of fluoxetine in human breast milk. J. Clin. Psychiatry 51, 169.

    PubMed  CAS  Google Scholar 

  112. Stancer, H. C. and Reed, K. L. (1986) Desipramine and 2-hydroxydesipramine in human breast milk and the nursing infant’s serum. Am. J. Psychiatry 143, 1597–600.

    PubMed  CAS  Google Scholar 

  113. Kemp, J., Ilett, K. F., Booth J., et al. (1985) Excretion of doxepin and N-desmethyldoxepin in human milk. Br. J. Clin. Pharmacol. 20, 497–499.

    PubMed  CAS  Google Scholar 

  114. Brixen-Rasmussen, L., Halgrener, J., and Jorgensen, A. (1982) Amitriptyline and nortriptyline excretion in human breast milk. Psychopharmacology 76, 94–95.

    PubMed  CAS  Google Scholar 

  115. Bader, T. F. and Newman, K. (1980) Amitriptyline in human breast milk and the nursing infant’s serum. Am. J. Psychiatry 137, 855–856.

    PubMed  CAS  Google Scholar 

  116. Erickson, S. H., Smith, G. H., and Heidrich, F. (1979) Tricyclics and breast feeding. Am. J. Psychiatry 136, 1483–1484.

    PubMed  CAS  Google Scholar 

  117. Chambers, C. D., Anderson, P. O., Thomas, R. G., et al. (1999) Weight gain in infants breastfed by mothers who take fluoxetine. Pediatrics 104(5), e61.

    Google Scholar 

  118. Brent, N. B. and Wisner K. L. (1998) Fluoxetine and carbamazepine concentrations in a nursing mother/infant pair. Clin. Pediatr. 37, 41–44.

    CAS  Google Scholar 

  119. Oo, C. Y., Kuhn, R. J., Desai, N., Wright, C. E, et al. (1995) Pharmacokinetics in lactating women: prediction of alprazolam transfer into milk. Br. J. Clin. Pharmacol. 40, 231–236.

    PubMed  CAS  Google Scholar 

  120. Lebedevs, T. H., Wojnar-Horton R. E., Yapp, P., et al. (1992) Excretion of temazepam in breast milk. Br. J. Clin. Pharmacol. 33, 204–206.

    PubMed  CAS  Google Scholar 

  121. Soderman, P. and Matheson, I. (1988) Clonazepam in breast milk. Eur. J. Pediatr. 147, 212–213.

    PubMed  CAS  Google Scholar 

  122. Wretlind, M. (1987) Excretion of oxazepam in breast milk. Eur. J. Clin. Pharmacol. 33, 209–210.

    PubMed  CAS  Google Scholar 

  123. Summerfield, R. J. and Nielsen, M. S. (1985) Excretion of lorazepam into breast milk. Br. J. Anaesth. 57, 1042–1043.

    PubMed  CAS  Google Scholar 

  124. Wesson, D. R., Camber, S., Harkey, M., et al. (1985) Diazepam and desmethyldiazepam in breast milk. J. Psychoactive Drugs 17, 55–56.

    PubMed  CAS  Google Scholar 

  125. Fisher, J. B., Edgren, B. E., Mammel, M. C., et al. (1985) Neonatal apnea associated with maternal clonazepam therapy: a case report. Obstet. Gynecol. 66(3 Suppl.), 34S–35S.

    PubMed  CAS  Google Scholar 

  126. Humpel, M., Stoppelli, I., Milia, S., et al. (1982) Pharmacokinetics and biotransformation of the new benzodiazepine, lormetazepam, in man. III. Repeated administration and transfer to neonates via breast milk. Eur. J. Clin. Pharmacol. 21, 421–425.

    PubMed  CAS  Google Scholar 

  127. Kok, T. H., Taitz, L. S., Bennett, M. J., et al. (1982) Drowsiness due to clemastine transmitted in breast milk. Lancet 1, 914–915.

    PubMed  CAS  Google Scholar 

  128. Brandt, R. (1976) Passage of diazepam and desmethyldiazepam into breast milk. Arzneimittel-Forschung 26, 454–457.

    PubMed  CAS  Google Scholar 

  129. Erkkola, R. and Kanto, J. (1972) Diazepam and breast-feeding. Lancet 1(7762), 1235–1236.

    Google Scholar 

  130. Liporace, J., Kao, A., and D’Abreu, A. (2004) Concerns regarding lamotrigine and breast-feeding. Epilepsy Behav. 5, 102–105.

    PubMed  Google Scholar 

  131. Frey, B., Braegger, C. P., and Ghelfi, D. (2002) Neonatal cholestatic hepatitis from carbamazepine exposure during pregnancy and breast feeding. Ann. Pharmacother. 36, 644–647.

    PubMed  Google Scholar 

  132. Ohman, I., Vitols, S., and Tomson, T. (2000) Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 41, 709–713.

    PubMed  CAS  Google Scholar 

  133. Piontek, C. M., Baab, S., Peindl, K. S., et al. (2000) Serum valproate levels in 6 breast-feeding mother-infant pairs. J. Clin. Psychiatry 61, 170–172.

    PubMed  CAS  Google Scholar 

  134. Wisner, K. L. and Perel, J. M. (1998) Serum levels of valproate and carbamazepine in breast-feeding mother-infant pairs. J. Clin. Psychopharmacol. 18, 167–169.

    PubMed  CAS  Google Scholar 

  135. Rambeck, B., Kurlemann, G., Stodieck, S. R., et al. (1997) Concentrations of lamotrigine in a mother on lamotrigine treatment and her newborn child. Eur. J. Clin. Pharmacol. 51, 481–484.

    PubMed  CAS  Google Scholar 

  136. Tomson, T., Ohman, I., and Vitols, S. (1997) Lamotrigine in pregnancy and lactation: a case report. Epilepsia 38, 1039–1041.

    PubMed  CAS  Google Scholar 

  137. Stahl, M. M., Neiderud, J., and Vinge, E. (1997) Thrombocytopenic purpura and anemia in a breast-fed infant whose mother was treated with valproic acid. J. Pediatr. 130, 1001–1003.

    PubMed  CAS  Google Scholar 

  138. Frey, B., Schubiger, G., and Musy, J. P. (1990) Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breastfeeding. Eur. J. Pediatr. 150, 136–138.

    PubMed  CAS  Google Scholar 

  139. Schou, M. (1990) Lithium treatment during pregnancy, delivery, and lactation: an update. J. Clin. Psychiatry 51, 410–413.

    PubMed  CAS  Google Scholar 

  140. Tsuru, N., Maeda, T., and Tsuruoka, M. (1988) Three cases of delivery under sodium valproate-placental transfer, milk transfer and probable teratogenicity of sodium valproate. Jpn. J. Psychiatry Neurol. 42, 89–96.

    PubMed  CAS  Google Scholar 

  141. Bardy, A. H., Hiilesmaa, V. K., and Teramo, K. A. (1987) Serumphenytoin during pregnancy, labor and puerperium. Acta Neurol. Scand. 75, 374–375.

    PubMed  CAS  Google Scholar 

  142. Pittard, W. B., 3rd. and O’Neal, W., Jr. (1986) Amitriptyline excretion in human milk. J. Clin. Psychopharmacol. 6, 383–384.

    Google Scholar 

  143. von Unruh, G. E., Froescher, W., Hoffmann, F., et al. (1984) Valproic acid in breast milk: how much is really there? Ther. Drug Monit. 6, 272–276.

    Google Scholar 

  144. Froescher, W., Eichelbaum, M., Niesen, M., et al. (1984) Carbamazepine levels in breast milk. Ther. Drug Monit. 6, 266–271.

    PubMed  CAS  Google Scholar 

  145. Kuhnz, W., Jager-Roman, E., Rating, D., et al. (1983) Carbamazepine and carbamazepine-10, 11-epoxide during pregnancy and postnatal period in epileptic mother and their nursed infants: pharmacokinetics and clinical effects. Pediatr. Pharmacol. 3(3-4), 199–208.

    Google Scholar 

  146. Philbert, A. and Dam, M. (1982) The epileptic mother and her child. Epilepsia 23, 85–99.

    PubMed  CAS  Google Scholar 

  147. Nau, H,. Rating, D., Koch, S., et al. (1981) Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother’s milk and clinical status in neonates of epileptic mothers. J. Pharmacol. Exp. Ther. 219, 768–777.

    PubMed  CAS  Google Scholar 

  148. Niebyl, J. R., Blake, D. A., Freeman, J. M., et al. (1979) Carbamazepine levels in pregnancy and lactation. Obstet. Gynecol. 53, 139–140.

    PubMed  CAS  Google Scholar 

  149. Sovner, R. and Orsulak, P. J. (1979) Excretion of imipramine and desipramine in human breast milk. Am. J. Psychiatry 136(4A), 451–452.

    Google Scholar 

  150. Alexander, F. W. (1979) Sodium valproate and pregnancy. Arch. Dis. Child. 54, 240.

    PubMed  CAS  Google Scholar 

  151. Dickinson, R. G., Harland, R. C., Lynn, R. K., et al. (1979) Transmission of valproic acid (Depakene) across the placenta: half-life of the drug in mother and baby. J. Pediatr. 94, 832–835.

    PubMed  CAS  Google Scholar 

  152. Pynnonen, S., Kanto, J., Sillanpaa, M., et al. (1977) Carbamazepine: placental transport, tissue concentrations in foetus and newborn, and level in milk. Acta Pharmacol. Toxicol. 41, 244–253.

    CAS  Google Scholar 

  153. Skausig, O. B. and Schou, M. (1977) [Breast feeding during lithium therapy. [Danish] Ugeskr. Laeg. 139, 400–401.

    PubMed  CAS  Google Scholar 

  154. Sykes, P. A., Quarrie, J., and Alexander, F. W. (1976) Lithium carbonate and breast-feeding. Br. Med. J. 2, 1299.

    PubMed  CAS  Google Scholar 

  155. Pynnonen, S. and Sillanpaa, M. (1975) Letter: carbamazepine and mother’s milk. Lancet 2(7934), 563.

    Google Scholar 

  156. Schou, M. and Amdisen, A. (1973) Lithium and pregnancy. 3. Lithium ingestion by children breast-fed by women on lithium treatment. Br. Med. J. 2, 138.

    PubMed  CAS  Google Scholar 

  157. Tunnessen, W. W., Jr. and Hertz, C. G. (1972) Toxic effects of lithium in newborn infants: a commentary. J. Pediatr. 81, 804–807.

    PubMed  Google Scholar 

  158. Fries, H. (1970) Lithium in pregnancy. Lancet 1, 1233.

    PubMed  CAS  Google Scholar 

  159. Weinstein, M. R. and Goldfield, M. (1969) Lithium carbonate treatment during pregnancy; report of a case. Dis. Nerv. Syst. 30, 828–832.

    PubMed  CAS  Google Scholar 

  160. Ilett, K. F., Hackett, L. P., Kristensen, J. H., et al. (2004) Transfer of risperidone and 9-hydroxyrisperidone into human milk. Ann. Pharmacother. 38, 273–276.

    PubMed  Google Scholar 

  161. Ambresin, G., Berney, P., Schulz, P., et al. (2004) Olanzapine excretion into breast milk: a case report. J. Clin. Psychopharmacol. 24, 93–95.

    PubMed  Google Scholar 

  162. Gardiner, S. J., Kristensen, J. H., Begg, E. J., et al. (2003) Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants. Am. J. Psychiatry 160(8), 1428–1431.

    Google Scholar 

  163. Tenyi, T., Csabi, G., and Trixler, M. (2000) Antipsychotics and breast-feeding: a review of the literature. Paediatr. Drugs 2, 23–28.

    PubMed  CAS  Google Scholar 

  164. Hill, R. C., McIvor, R. J., Wojnar-Horton, R. E., et al. (2000) Risperidone distribution and excretion into human milk: case report and estimated infant exposure during breast-feeding. J. Clin. Psychopharmacol. 20, 285–286.

    PubMed  CAS  Google Scholar 

  165. Barnas, C., Bergant, A., Hummer, M., et al. (1994) Clozapine concentrations in maternal and fetal plasma, amniotic fluid, and breast milk. Am. J. Psychiatry 151, 945.

    PubMed  CAS  Google Scholar 

  166. Olesen, O. V., Bartels, U., and Poulsen, J. H. (1990) Perphenazine in breast milk and serum. Am. J. Psychiatry 147, 1378–1379.

    PubMed  CAS  Google Scholar 

  167. Whalley, L. J., Blain, P. G., and Prime, J. K. (1981) Haloperidol secreted in breast milk. Br. Med. J. Clin. Res. Ed. 282, 1746–1747.

    PubMed  CAS  Google Scholar 

  168. Stewart, R. B., Karas, B., and Springer, P. K. (1980) Haloperidol excretion in human milk. Am. J. Psychiatry 137, 849–850.

    PubMed  CAS  Google Scholar 

  169. Wiles, D. H., Orr, M. W., and Kolakowska, T. (1978) Chlorpromazine levels in plasma and milk of nursing mothers. Br. J. Clin. Pharmacol. 5, 272–273.

    PubMed  CAS  Google Scholar 

  170. Birnbaum, C. S., Cohen, L. S., Bailey, J. W., et al. (1999) Serum concentrations of antidepressants andbenzodiazepines in nursing infants: a case series. Pediatrics 104(1), e11.

    Google Scholar 

  171. Dusci, L. J., Good, S. M., Hall, R. W., et al. (1990) Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam. Br. J. Clin. Pharmacol. 29, 123–126.

    PubMed  CAS  Google Scholar 

  172. Patrick, M. J., Tilstone, W. J., and Reavey, P. (1972) Diazepam and breast-feeding. Lancet 1, 542–544.

    PubMed  CAS  Google Scholar 

  173. Pons, G., Francoual, C., Guillet P., et al. (1989) Zolpidem excretion in breast milk. Eur. J. Clin. Pharmacol. 37, 245–248.

    PubMed  CAS  Google Scholar 

  174. Darwish, M., Martin, P. T., Cevallos, W. H., et al. (1999) Rapid disappearance of zaleplon from breast milk after oral administration to lactating women. J. Clin. Pharmacol. 39, 670–674.

    PubMed  CAS  Google Scholar 

  175. Chaudron, L. H. and Jefferson, J. W. (2000) Mood stabilizers during breast-feeding: a review. J. Clin. Psychiatry 61, 79–90.

    PubMed  CAS  Google Scholar 

  176. Iqbal, M. M., Gundlapalli, S. P., Ryan, W. G., et al. (2001) Effects of antimanic mood-stabilizing drugs on fetuses, neonates, and nursing infants. South. Med. J. 94, 304–322.

    PubMed  CAS  Google Scholar 

  177. Yoshida, K., Smith, B., Craggs, M., et al. (1998) Neuroleptic drugs in breast-milk: a study of pharmacokinetics and of possible adverse effects in breast-fed infants. Psychol. Med. 28, 81–91.

    PubMed  CAS  Google Scholar 

  178. Goldstein, D. J., Corbin, L. A., and Fung, M. C. (2000) Olanzapine-exposed pregnancies and lactation: early experience. J. Clin. Psychopharmacol. 20, 399–403.

    PubMed  CAS  Google Scholar 

  179. Stowe, Z. N., Hostetter, A. L., Owens, M. J., et al. (2003) The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations. J. Clin. Psychiatry 64, 73–80.

    PubMed  CAS  Google Scholar 

  180. Epperson, N., Czarkowski, K. A., Ward-O’Brien, D., et al. (2001) Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs. Am. J. Psychiatry 158, 1631–1637.

    PubMed  CAS  Google Scholar 

  181. Wisner, K. L., Perel, J. M., and Blumer, J. (1998) Serum sertraline and N-desmethylsertraline levels in breast-feeding mother-infant pairs. Am. J. Psychiatry 155, 690–692.

    PubMed  CAS  Google Scholar 

  182. Wisner, K. L., Perel, J. M., and Blumer, J. (1998) Serum sertraline and N-desmethylsertraline levels in breast-feeding mother-infant pairs. Am. J. Psychiatry 155, 690–692.

    PubMed  CAS  Google Scholar 

  183. Kristensen, J. H., Ilett, K. F, Dusci, L. J., et al. (1998) Distribution and excretion of sertraline and N-desmethylsertraline in human milk. Br. J. Clin. Pharmacol. 45, 453–457.

    PubMed  CAS  Google Scholar 

  184. Mammen, O. K., Perel, J. M., Rudolph, G., et al. (1997) Sertraline and norsertraline levels in three breastfed infants. J. Clin. Psychiatry 58, 100–103.

    PubMed  CAS  Google Scholar 

  185. Altshuler, L. L., Burt, V. K., McMullen, M., et al. (1995) breast-feeding and sertraline: a 24-hour analysis. J. Clin. Psychiatry 56, 243–245.

    PubMed  CAS  Google Scholar 

  186. Suri, R., Stowe, Z. N., Hendrick, V., et al. (2002) Estimates of nursing infant daily dose of fluoxetine through breast milk. Biol. Psychiatry 52, 446–451.

    PubMed  CAS  Google Scholar 

  187. Kristensen, J. H, Ilett, K. F., Hackett, L. P., et al. (1999) Distribution and excretion of fluoxetine and norfluoxetine in human milk. Br. J. Clin. Pharmacol. 48, 521–527.

    PubMed  CAS  Google Scholar 

  188. Yoshida, K., Smith, B., Craggs, M., et al. (1998) Fluoxetine in breast-milk and developmental outcome of breast-fed infants. Br. J. Psychiatry 172, 175–178.

    PubMed  CAS  Google Scholar 

  189. Taddio, A., Ito, S., and Koren, G. (1996) Excretion of fluoxetine and its metabolite, norfluoxetine, in human breast milk. J. Clin. Pharmacol. 36, 42–47.

    PubMed  CAS  Google Scholar 

  190. Lester, B. M., Cucca, J., Andreozzi, L., et al. (1993) Possible association between fluoxetine hydrochloride and colic in an infant. J. Am. Acad. Child Adolesc. Psychiatry 32, 1253–1255.

    PubMed  CAS  Google Scholar 

  191. Burch, K. J. and Wells, B. G. (1992) Fluoxetine/norfluoxetine concentrations in human milk. Pediatrics 89(4 Pt. 1), 676–677.

    PubMed  CAS  Google Scholar 

  192. Merlob, P., Mor, N., and Litwin, A. (1992) Transient hepatic dysfunction in an infant of an epileptic mother treated with carbamazepine during pregnancy and breast-feeding. Ann. Pharmacother. 26, 1563–1565.

    PubMed  CAS  Google Scholar 

  193. Hendrick, V., Stowe, Z. N., Altshuler, L. L., et al. (2000) Paroxetine use during breast-feeding. J. Clin. Psychopharmacol. 20, 587–589.

    PubMed  CAS  Google Scholar 

  194. Begg, E. J., Duffull, S. B., Saunders, D. A., et al. (1999) Paroxetine in human milk. Br. J. Clin. Pharmacol. 48, 142–147.

    PubMed  CAS  Google Scholar 

  195. Ohman R., Hagg, S., Carleborg, L., et al. (1999) Excretion of paroxetine into breast milk. J. Clin. Psychiatry 60, 519–523.

    PubMed  CAS  Google Scholar 

  196. Misri, S., Kim, J., Riggs, K.W., et al. (2000) Paroxetine levels in postpartum depressed women, breast milk, and infant serum. J. Clin. Psychiatry 61, 828–832.

    PubMed  CAS  Google Scholar 

  197. Spigset, O., Carleborg, L., Norstrom, A., et al. (1996) Paroxetine level in breast milk. J. Clin. Psychiatry 57, 39.

    PubMed  CAS  Google Scholar 

  198. Lee, A., Woo,., and Ito, S. (2004) Frequency of infant adverse events that are associated with citalopram use during breast-feeding. Am. J. Obstet. Gynecol. 190, 218–221.

    PubMed  CAS  Google Scholar 

  199. Heikkinen, T., Ekblad, U., Kero, P., et al. (2002) Citalopram in pregnancy and lactation. Clin. Pharmacol Ther. 72, 184–191.

    PubMed  Google Scholar 

  200. Schmidt, K., Olesen, O. V., and Jensen, P. N. (2000) Citalopram and breastfeeding: serum concentration and side effects in the infant. Biol. Psychiatry 47, 164–165.

    PubMed  CAS  Google Scholar 

  201. Rampono, J., Kristensen, J. H., Hackett, L. P., et al. (2000) Citalopram and demethylcitalopram in human milk; distribution, excretion and effects in breast fed infants. Br. J. Clin. Pharmacol. 50, 263–268.

    PubMed  CAS  Google Scholar 

  202. Jensen, P. N., Olesen, O. V,. Bertelsen, A., et al. (1997) Citalopram and desmethylcitalopram concentrations in breast milk and in serum of mother and infant. Ther. Drug Monit. 19, 236–239.

    PubMed  CAS  Google Scholar 

  203. Spigset, O., Carieborg, L., Ohman, R., et al. (1997) Excretion of citalopram in breast milk. Br. J. Clin. Pharmacol. 44, 295–298.

    PubMed  CAS  Google Scholar 

  204. Kristensen, J. H., Hackett, L. P., Kohan, R., et al. (2002) The amount of fluvoxamine in milk is unlikely to be a cause of adverse effects in breastfed infants. J. Hum. Lactation 18, 139–143.

    Google Scholar 

  205. Piontek, C. M., Wisner, K. L., Perel, J. M., et al. (2001) Serum fluvoxamine levels in breastfed infants. J. Clin. Psychiatry 62, 111–113.

    PubMed  CAS  Google Scholar 

  206. Yoshida, K., Smith, B., Craggs, M.,et al. (1997)Investigation of pharmacokinetics and of possible adverse effects in infants exposed to tricyclic antidepressants in breast-milk. J. Affect. Disord. 43, 225–237.

    PubMed  CAS  Google Scholar 

  207. Wright, S., Dawling, S., and Ashford, J. J. (1991) Excretion of fluvoxamine in breast milk. Br. J. Clin. Pharmacol. 31, 209.

    PubMed  CAS  Google Scholar 

  208. Briggs, G. G., Samson, J. H., Ambrose, P. J., et al. (1993) Excretion of bupropion in breast milk. Ann. Pharmacother. 27, 431–433.

    PubMed  CAS  Google Scholar 

  209. Baab, S. W., Peindl, K. S., Piontek, C M., and Wisner, K. L. (2002) Serumbupropion levels in 2 breastfeeding mother-infant pairs. J. Clin. Psych. 63, P.

    Google Scholar 

  210. Chaudron, L. H. and Schoenecker, C. J. (2004) Bupropion and breastfeeding: A case of a possible infant seizure. J. Clin. Psych. 65, 881–882.

    Google Scholar 

  211. Hendrick, V., Altshuler, L., Wertheimer, A., and Dunn, W. A. (2001) Venlafaxine and breast-feeding. Am. J. Psychiatry 158(12), 2089–2090.

    PubMed  CAS  Google Scholar 

  212. Ilett, K. F., Kristensen, J. H., Hackett, L. P., et al. (2002) Distribution of venlafaxine and its O-desmethyl metabolite in human milk and their effects in breastfed infants. Br. J. Clin. Pharmacol. 53, 17–22.

    PubMed  CAS  Google Scholar 

  213. Hart, S., Field, T., Jones, N., et al. (1999) Intrusive and withdrawn behaviours of mothers interacting with their infants and boyfriends. J. Child Psychol. Psychiatry Allied Disciplines 40, 239–245.

    CAS  Google Scholar 

  214. Caplan, H. L., Cogill, S. R., Alexandra, H., et al. (1989) Maternal depression and the emotional development of the child. Br. J. Psychiatry 154, 818–822.

    PubMed  CAS  Google Scholar 

  215. Breznitz, Z. and Sherman, T. (1987) Speech patterning of natural discourse of well and depressed mothers and their young children. Child Dev. 58, 395–400.

    PubMed  CAS  Google Scholar 

  216. Jones, N. A., Field T., and Davalos, M. (2000) Right frontal EEG asymmetry and lack of empathy in preschool children of depressed mothers. Child Psychiatry Hum. Dev. 30, 189–204.

    PubMed  CAS  Google Scholar 

  217. Field, T., Lang, C., Yando, R., et al. (1995) Adolescents’ intimacy with parents and friends. Adolescence 30, 133–140.

    PubMed  CAS  Google Scholar 

  218. Warner, R., Appleby, L., Whitton, A., et al. (1996) Demographic and obstetric risk factors for postnatal psychiatric morbidity. Br. J. Psychiatry 168, 607–611.

    PubMed  CAS  Google Scholar 

  219. O’Hara, M. W., Stuart, S, Gorman, L. L., et al. (2000) Efficacy of interpersonal psychotherapy for postpartum depression. Arch. Gen. Psychiatry 57, 1039–1045.

    PubMed  CAS  Google Scholar 

  220. Epperson, C. N., Wisner, K. L., and Yamamoto, B. (1999) Gonadal steroids in the treatment of mood disorders. Psychosom. Med. 61, 676–697.

    PubMed  CAS  Google Scholar 

  221. Gregoire, A. J., Kumar, R., Everitt, B., et al. (1996) Transdermal oestrogen fo treatment of severe postnatal depression. Lancet 347, 930–933.

    PubMed  CAS  Google Scholar 

  222. Stowe, Z. N., Casarella J., Landry J., et al. (1995) Sertraline in the treatment of women with postpartum major depression. Depression 3, 49–55.

    Google Scholar 

  223. Granger, A. C. and Underwood, M. R. (2001) Review of the role of progesterone in the management of postnatal mood disorders. J. Psychosom. Obstet. Gynecol. 22, 49–55.

    CAS  Google Scholar 

  224. Rabheru, K. (2001) The use of electroconvulsive therapy in special patient populations. Can. J. Psychiatry 46, 710–719.

    PubMed  CAS  Google Scholar 

  225. Gruen, D. S. (1993) A group psychotherapy approach to postpartum depression. Int. J. Group Psychother. 43, 191–203.

    PubMed  CAS  Google Scholar 

  226. Armstrong, K. L, Van Haeringen, A. R., Dadds, M. R., et al. (1998) Sleep deprivation or postnatal depression in later infancy: separating the chicken from the egg. J. Paediatr. Child Health 34, 260–262.

    PubMed  CAS  Google Scholar 

  227. Corral, M., Kuan, A., and Kostaras, D. (2000) Bright light therapy’s effect on postpartum depression. Am. J. Psychiatry 157, 303–304.

    PubMed  CAS  Google Scholar 

  228. Field, T., Grizzle, N., Scafidi F., et al. (1996) Massage and relaxation therapies’ effects on depressed adolescent mothers. Adolescence 31, 903–911.

    PubMed  CAS  Google Scholar 

  229. Stamp, G. E., Williams, A. S., Crowther, C. A. (1995) Evaluation of antenatal and postnatal support to overcome postnatal depression: a randomized, controlled trial. Birth 22, 138–143.

    PubMed  CAS  Google Scholar 

  230. Zlotnick, C., Johnson, S. L., Miller, I. W., et al. (2001) Postpartum depression in women receiving public assistance: pilot study of an interpersonal-therapyoriented group intervention. Am. J. Psychiatry 158, 638–640.

    PubMed  CAS  Google Scholar 

  231. Murray, L., Cooper, P., and Hipwell, A. (2003) Mental health of parents caring for infants. Arch. Women’s Mental Health 6 (Suppl. 2), S71–77.

    Google Scholar 

  232. Wisner, K. L., Perel, J. M., Peindl, K. S., et al. (2004) Timing of depression recurrence in the first year after birth. J. Affect. Disord. 78, 249–252.

    PubMed  Google Scholar 

  233. Wisner, K. L., Perel, J. M., Peindl, K. S., et al. (2001) Prevention of recurrent postpartum depression: a randomized clinical trial. J. Clin. Psychiatry 62, 82–86.

    PubMed  CAS  Google Scholar 

  234. Hibbeln, J. R. (2002) Seafood consumption, the DHA content of mothers’ milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. J. Affect. Disord. 69(1-3), 15–29.

    PubMed  CAS  Google Scholar 

  235. Chaudron, L. H. and Pies, R. W. (2003) The relationship between postpartum psychosis and bipolar disorder: a review. J. Clin. Psychiatry 64, 1284–1292.

    PubMed  Google Scholar 

  236. Burgess, P., Pirkis, J., Morton, J., et al. (2000) Lessons from a comprehensive clinical audit of users of psychiatric services who committed suicide. Psychiatr. Serv. 51, 1555–1560.

    PubMed  CAS  Google Scholar 

  237. Nurnberg, H. G. (1989) An overview of somatic treatment of psychosis during pregnancy and postpartum. Gen. Hosp. Psychiatry 11, 328–338.

    PubMed  CAS  Google Scholar 

  238. Hamilton, M. (1984) Depression and endogenicity. Acta Psychiatr. Belg. 84, 240–248.

    PubMed  CAS  Google Scholar 

  239. Reed, P., Sermin, N., Appleby, L., et al. (1999) A comparison of clinical response to electroconvulsive therapy in puerperal and non-puerperal psychoses. J. Affect. Disord. 54, 255–260.

    PubMed  CAS  Google Scholar 

  240. Cohen, L. S., Sichel, D. A., Robertson, L. M., et al. (1995)Postpartumprophylaxis for women with bipolar disorder. Am. J. Psychiatry 152, 1641–1645.

    PubMed  CAS  Google Scholar 

  241. Viguera, A. C., Nonacs, R., Cohen, L. S., et al. (2000) Risk of recurrence of bipolar disorder in pregnant and nonpregnant women after discontinuing lithium maintenance. Am. J. Psychiatry 157, 179–184.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Yale Behavioral Gynecology Program, Departments of Psychiatry and Obstetrics, Gynecology and Reproductive science, Yale University School of Medicine, New Haven, CT

    C. Neill Epperson

  2. Clinical Neuroscience Training Program, Department of Psychiatry, Yale University School of Medicine, New Haven, CT

    Jennifer Ballew

Authors
  1. C. Neill Epperson
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  2. Jennifer Ballew
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Editors and Affiliations

  1. Olive View-UCLA Medical Center, Sylmar, CA

    Victoria Hendrick MD

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© 2006 Humana Press Inc., Totowa, NJ

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Neill Epperson, C., Ballew, J. (2006). Postpartum Depression. In: Hendrick, V. (eds) Psychiatric Disorders in Pregnancy and the Postpartum. Current Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-59745-013-3_3

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  • DOI: https://doi.org/10.1007/978-1-59745-013-3_3

  • Publisher Name: Humana Press

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