Abstract
Carotid artery stenosis is a prevalent disease, caused predominantly by atherosclerosis. The reported prevalence is dependent on the population screened, investigative tool used, and the criteria employed. The presence of carotid artery stenosis is associated with an increased risk of stroke and other ischemic manifestations of systemic atherosclerosis (e.g., myocardial infarctions and vascular deaths). Thus, carotid revascularization strategies for stroke prevention had been aggressively pursued over the past five decades. This chapter reviews the epidemiology and prevalence of carotid artery stenosis.
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References
Fine-Edelstein JS, Wolf PA, O’Leary DH, et al. Precursors of extracranial carotid atherosclerosis in the Framingham Study. Neurology 1994;44:1046–1050.
Rockman CB, Jacobowitz GR, Gagne PJ, et al. Focused screening for occult carotid artery disease: patients with known heart disease are at high risk. J Vasc Surg 2004;39:44–51.
AHA. American Heart Association. Heart Disease and Stroke Statistics-2005 Update. Dallas, TX: American Heart Association; 2004. http://americanheart.org 2005.
Clou GC, Marku HS. Diagnosis and management of vertebral artery stenosis. QJM 2003;96:27–54.
Sacco RL. Extracranial carotid stenosis. N Engl J Med 2001;345:1113–1118.
Petty GW, Brow RD, Jr., Whisnant JP, Sicks JD, O’Fallon WM, Wiebers DO. Ischemic stroke subtypes: a population-based study of incidence and risk factors. Stroke 1999;30:2513–2516.
White H, Boden-Albala B, Wang C, et al. Ischemic stroke subtype incidence among whites, blacks, and Hispanics: the Northern Manhattan Study. Circulation 2005;111:1327–1331.
Sacco RL, Kargman DE, Gu Q, Zamanillo MC. Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction. The Northern Manhattan Stroke Study. Stroke 1995;26:14–20.
Tegeler C, Shi F, Morgan T. Carotid stenosis in lacunar stroke. Stroke 1991;22:1124–1128.
Griffiths PD, Worthy S, Gholkar A. Incidental intracranial vascular pathology in patients investigated for carotid stenosis. Neuroradiology 1996;38:25–30.
Kappelle LJ, Eliasziw M, Fox AJ, Sharpe BL, Barnett HJ. Importance of intracranial atherosclerotic disease in patients with symptomatic stenosis of the internal carotid artery. Stroke 1999;30:282–286.
Roederer G, Langlois Y, Jager K, et al. The natural history of carotid arterial disease in asymptomatic patients with cervical bruits. Stroke 1984;15:605–613.
Chambers BR, Norris JW. Outcome in patients with asymptomatic neck bruits. N Engl J Med 1986;315:860–865.
Norris JW, Zhu CZ, Bornstein NM, Chambers BR. Vascular risks of asymptomatic carotid stenosis. Stroke 1991;22:1485–1490.
Mancini GB, Dahlof B, Diez J. Surrogate markers for cardiovascular disease: structural markers. Circulation 2004;109:IV22–30.
O’Leary DH, Polak JF, Kronmal RA, et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. N Engl J Med 1999;340:14–22.
Eagle K, Guyton R, Davidoff R, et al. ACC/AHA 2004 guideline update for coronary artery bypass graft surgery: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for Coronary Artery Bypass Graft Surgery). J Am Coll Cardiol 2004;44:1146–1154, e213–310.
Simons PC, Algra A, Eikelboom BC, Grobbee DE, van der Graaf Y. Carotid artery stenosis in patients with peripheral arterial disease: the SMART study. SMART study group. J Vasc Surg 1999;30:519–525.
House AK, Bell R, House J, Mastaglia F, Kumar A, D’Antuono M. Asymptomatic carotid artery stenosis associated with peripheral vascular disease: a prospective study. Cardiovasc Surg 1999;7:44–49.
Rockman CB, Riles TS, Lamparello PJ, et al. Natural history and management of the asymptomatic, moderately stenotic internal carotid artery. J Vasc Surg 1997;25:423–431.
NASCET Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 1991;325:445–453.
ACAS. Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA 1995;273:1421–1428.
ACST Collaborative Group. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet 2004;363:p1491–p1502.
Obuchowski NA, Modic MT, Magdinec M, Masaryk TJ. Assessment of the efficacy of noninvasive screening for patients with asymptomatic neck bruits. Stroke 1997;28:1330–1339.
Barnett HJ, Eliasziw M, Meldrum H. Plaque morphology as a risk factor for stroke. JAMA 2000;284:177.
Mathiesen EB, Bonaa KH, Joakimsen O. Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: the Tromso Study. Circulation 2001;103:2171–2175.
Polak J, Shemanski L, O’Leary D, et al. Hypoechoic plaque at US of the carotid artery: an independent risk factor for incident stroke in adults aged 65 years or older. Cardiovascular Health Study [published erratum appears in Radiology 1998 Oct;209(1):288-289]. Radiology 1998;208:649–654.
Eliasziw M, Streifler JY, Fox AJ, Hachinski VC, Ferguson GG, Barnett HJ. Significance of plaque ulceration in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial. Stroke 1994;25:304–308.
Hertzer NR, Young JR, Beven EG, et al. Coronary angiography in 506 patients with extracranial cerebrovascular disease. Arch Intern Med 1985;145:849–852.
Bittl JA, Hirsch AT. Concomitant peripheral arterial disease and coronary artery disease: therapeutic opportunities. Circulation 2004;109:3136–3144.
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© 2007 Humana Press Inc., Totowa, NJ
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Fung, A.Y., Saw, J. (2007). Epidemiology and Significance of Carotid Artery Stenosis. In: Saw, J., Exaire, J.E., Lee, D.S., Yadav, J.S. (eds) Handbook Of Complex Percutaneous Carotid Intervention. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-002-7_1
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DOI: https://doi.org/10.1007/978-1-59745-002-7_1
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