Abstract
Lupus is a serious, potentially life-threatening disease. Its natural history is to culminate in a crescendo of autoimmunity and organ involvement. Difficulty arriving at the diagnosis may delay institution of therapy, which although helpful brings new problems. The fundamental understanding of this disease has made major strides. There is no consensus on the likely etiological agent(s), though evidence implicates Epstein-Barr virus, and the genetic approach to understanding etiology is in its infancy. Nevertheless, efficacious treatments are anticipated in the plethora of new biologics likely to have therapeutic effects in lupus, essentially a disease of immune dysregulation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Selected References
Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Parks CG, Gilkeson GS. Hormonal, environmental, and infectious risk factors for developing systemic lupus erythematosus. Arthritis Rheum 1998;41(10):1714–1724.
Golan TD, Elkon KB, Gharavi AE, Krueger JG. Enhanced membrane binding of autoantigens to cultured keratinocytes of systemic lupus erythematosus patients after ultraviolet B/ultraviolet A irradiation J Clin Invest 1992;90:1067–1076.
Harley JB, Reichlin M, Arnett FC, Alexander EL, Bias WB, Provost TT. Gene interaction at HLA-DQ enhances autoantibody production in primary Sjögren’s syndrome. Science 1986;232:1145–1147.
James JA, Harley JB, Scofield RH. Role of viruses in systemic lupus erythe-matousus and Sjögren’s syndrome. Curr Opin Rheum 2001;13:370–376.
James JA, Gross T, Scofield RH, Harley JB. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B( derived PPPGMRPP and PPPGIRGP induced spliceosome autoimmunity. J Exp Med 1995;181:453–461.
James JA, Kaufman KM, Farris AD, Taylor-Albert E, Lehman TJA, Harley JB. An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus. J Clin Invest 1997;100:3019–3026.
Kawashima T, Zappi EG, Lieu TS, Sontheimer RD. Impact of ultraviolet radiation on the cellular expression of Ro/SS-A-autoantigenic polypeptides. Dermatology 1994;189:6–10.
Kelly JA, Moser KL, Harley JB. The genetics of systemic lupus erythematosus: putting the pieces together. Genes Immun 2002;3(Suppl 1): S71–S85.
Molina H. Update on complement in the pathogenesis of systemic lupus erythematosus. Curr Opin Rheum 2002;14:492–497.
Reichlin M. Autoantibodies to the RoRNP particles. Clin Exp Immunol 1995;99(1):7–9.
Richardson B. DNA methylation and autoimmune disease. Clin Immunol 2003;109:72–79.
Sawalha AH, Richardson BC. DNA methylation in the pathogenesis of systemic lupus erythematosus. Current Pharmacogenomics 2005;3:73–78.
Smoller BR, Horn TD. Lupus erythematosus. In: Smoller BR, Horn TD, eds. Dermatopathology in Systemic Disease, 1st ed. New York: Oxford, 2001, pp. 3–16.
Sontheimer RD, Provost TT. Lupus erythematosus. In: Sontheimer RD, Provost TT, eds. Cutaneous Manifestations of Rheumatic Diseases, 1st ed. Baltimore: Williams and Wilkins, 1996, pp. 1–71.
Srivastava M, Rencic A, Diglio G, et al. Drug-induced, Ro/SSA-positive cutaneous lupus erythematosus. Arch Dermatol 2003;139:45–49.
Wallace D. Management of lupus erythematosus: recent insights. Curr Opin Rheum 2002;14:212–219.
Yung RL, Quddus J, Chrisp CE, Johnson KJ, Richardson BC. Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo. J immunol 1995;154:3025–3035.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Humana Press Inc.
About this chapter
Cite this chapter
Sawalha, A.H., Diaz, L.A., Harley, J.B. (2006). Systemic Lupus Erythematosus. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Medicine. Humana Press. https://doi.org/10.1007/978-1-59259-963-9_99
Download citation
DOI: https://doi.org/10.1007/978-1-59259-963-9_99
Publisher Name: Humana Press
Print ISBN: 978-1-58829-202-5
Online ISBN: 978-1-59259-963-9
eBook Packages: MedicineMedicine (R0)