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Multiple Myeloma

A Story of Genes and the Environment

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Principles of Molecular Medicine

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Abstract

Multiple myeloma (MM) is characterized by the clonal expansion of mature B cells within bone marrow. This malignancy is believed to arise from mutations involving nonrandom translocations between specific oncogenes and immunoglobulin coding regions of B cells. Further mutations parallel a relatively welldescribed progression from benign MGUS to MM and secondary plasma cell leukemia. Current literature suggests that in addition to genetic adaptations, specific effectors of the bone marrow microenvironment might contribute significantly to both MM pathogenesis as well as to treatment failure. Within this chapter we discuss the molecular and biochemical factors that contribute to malignant potential of MM.

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Authors and Affiliations

  1. Experimental Therapeutics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

    Kenneth H. Shain & William S. Dalton

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  1. Kenneth H. Shain
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  2. William S. Dalton
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Editors and Affiliations

  1. Department of Medicine, Division of Cardiology Carolina Cardiovascular Biology Center, University of North Carolina School of Medicine, Chapel Hill, NC

    Marschall S. Runge MD, PhD  & Cam Patterson MD  & 

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© 2006 Humana Press Inc.

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Shain, K.H., Dalton, W.S. (2006). Multiple Myeloma. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Medicine. Humana Press. https://doi.org/10.1007/978-1-59259-963-9_83

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  • DOI: https://doi.org/10.1007/978-1-59259-963-9_83

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-202-5

  • Online ISBN: 978-1-59259-963-9

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