Abstract
This chapter describes non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL). NHL is a complex and heterogeneous group of disorders characterized by clonal proliferation f lymphocytes at different stages of maturation. There are approx 30 types of NHL with varying clinical, pathological, and genetic features. Understanding some of its biological features has provided insights into the clinical behavior of NHL. CLL is a neoplasm of monomorphic small, round lymphocytes of B cell origin in 98% of the cases. It is the most frequent type of leukemia in the United States and Europe where the majority of patients are older than 50; it has a male:female ratio of 2:1. CLL remains an incurable, chronic disease with a variable survival depending on clinical stage at presentation.
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Selected References
Aalto Y, El-Rifa W, Vilpo L, et al. Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion. Leukemia 2001; 15:1721–1728.
Athanasiou E, Kotoula V, Hytiroglou p, Kouidou S, Kaloutsi V, Papadimitriou CS. In situ hybridization and reverse transcription-polymerase chain reaction for cycline D1 mRNA in the diagnosis of mantle cell lymphoma in paraffin-embedded tissues. Mod Pathol 2001; 14:62–70.
Barrans SL, O’Connor SJ, Evans PA, et al. Rearrangement of the BCL6 locus at 3q27 is an independent poor prognostic factor in nodal diffuse large B-cell lymphoma. Br J Haematol 2002;117:322–332.
Crossen PE. Genes and chromosomes in chronic B-cell leukemia. Cancer Genet Cytogenet 1997;94:44–51.
Du M-Q, Isaccson PG. Gastric MALT lymphoma: from aetiology to treatment. Lancet Oncol 2002;3:97–104.
Hecht JL, Aster JC. Molecular Biology of Burkitt’s lymphoma. J Clin Oncol 2000;18:3707–3721.
Horsman DE, Connors JM, Pantzar T, Gascoyne RD. Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18). Genes Chromosomes Cancer 2001;30:375–382.
Husson H, Carideo EG, Neuberg D, et al. Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays. Blood 2002;99:282–289.
Jaffe ES, Harris NL, Stein H, Vardiman JW (eds). World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2001.
Kowaltowski AJ, Cosso RG, Campos CB, Fiskum G. Effect of Bcl-2 overexpression on mitochondrial structure and function. J Biol Chem 2002;277:42,802–42,807.
Kramer MH, Hermans J, Wijburg E, et al. Clinical relevance of BCL2, BCL6 and MYC rearrangements in diffuse large B-cell lymphoma. Blood 1998;92:3152–3162.
Kuppers R, Klein U, Hansmann ML, Rajewsky K. Cellular origin of human B-cell lymphomas. N Engl J Med 1999;341:1520–1529.
Kutok JL, Aster JC. Molecular biology of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. J Clin Oncol 2002;20:3691–3702.
Ladanyi M. The NPM/ALK gene fusion in the pathogenesis of anaplastic large cell lymphoma. Cancer Surv 1997;30:59–75.
Mohamed AN, Palutke M, Eisenberg L, Al-Katib A. Chromosomal analysis of 52 follicular lymphoma with t(14;18), including blastic/blastoid variant. Cancer Genet Cytogenet 2001;126:45–51.
Sanchez-Beato M, Sanchez-aguilera A, Piris MA. Cell cycle deregulation in B-cell lymphomas. Blood 2003;101:1220–1235.
Stein H, Foss HD, Durkop H, et al. CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood 2000;96:3681–3695.
Tsujimoto Y, Croce CM. Molecular genetics of human B-cell neoplasia. Curr Top Microbiol Immunol 1986;132:183–192.
Tsujimoto Y, Yunis J, Onorato-Showe L, Erikson J, Nowell PC, Croce CM. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science 1984;224:1403–1406.
Vidal A, Koff A. Cell-cycle inhibitors: three families united by a common cause. Gene 2000;247:1–15.
Wessendorf S, Schwaenen C, Kohlhammer H, et al. Hidden gene amplifications in aggressive B-cell non-Hodgkin lymphomas detected by microarray-based comparative genomic hybridizatin. Oncogene 2003; 22:1425–1429.
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Al-Katib, A.M., Mohamed, A.N. (2006). Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Medicine. Humana Press. https://doi.org/10.1007/978-1-59259-963-9_82
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DOI: https://doi.org/10.1007/978-1-59259-963-9_82
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