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Oligomerization Domains of G Protein-Coupled Receptors

Insights Into the Structural Basis of GPCR Association

  • Chapter
The G Protein-Coupled Receptors Handbook

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

Many recent reviews have thoroughly described the ability of a wide range of G protein-coupled receptors (GPCRs) to exist and to potentially function as oligomers (1–6). This chapter summarizes the computational and experimental studies that have provided insight into the understanding of the structural basis of GPCR association. Particular emphasis is placed on the combined computational and experimental approach that we have recently developed to characterize the homodimerization interface of rhodopsin-like GPCRs.

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Author information

Authors and Affiliations

  1. Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY

    Marta Filizola PhD & Harel Weinstein DSc

  2. Center for Molecular Recognition, Columbia University College of Physicians & Surgeons, New York, NY

    Wen Guo PhD & Jonathan A. Javitch MD, PhD

Authors
  1. Marta Filizola PhD
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  2. Wen Guo PhD
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  3. Jonathan A. Javitch MD, PhD
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  4. Harel Weinstein DSc
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Editors and Affiliations

  1. Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY

    Lakshmi A. Devi PhD

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Filizola, M., Guo, W., Javitch, J.A., Weinstein, H. (2005). Oligomerization Domains of G Protein-Coupled Receptors. In: Devi, L.A. (eds) The G Protein-Coupled Receptors Handbook. Contemporary Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-59259-919-6_11

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