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Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol

Applications to Glucocorticoids and 5-Fluorouracil

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Cancer Chemoprevention

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Aerosol administration of chemopreventive agents has distinct advantages in chemoprevention of respiratory tract carcinogenesis. First, the agent is delivered directly to the target tissue. Another major advantage is the favorable ratio of agent concentration reaching the respiratory tract as compared to that reaching the systemic tissues. At the same dose, the initial agent concentration in the lung will be approx 30x greater when the compounds are given by aerosol than when administered orally (1). This difference is further enhanced for agents that undergo metabolism in systemic tissues (2).

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Authors
  1. Timothy S. Wiedmann PhD
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  2. Lee W. Wattenberg MD
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Editor information

Editors and Affiliations

  1. National Institutes of Health, Rockville, MD, USA

    Gary J. Kelloff MD  & Ernest T. Hawk MD, MPH  & 

  2. CCS Associates, Mountain View, CA, USA

    Caroline C. Sigman PhD

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Wiedmann, T.S., Wattenberg, L.W. (2004). Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol. In: Kelloff, G.J., Hawk, E.T., Sigman, C.C. (eds) Cancer Chemoprevention. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-767-3_9

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  • DOI: https://doi.org/10.1007/978-1-59259-767-3_9

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-342-8

  • Online ISBN: 978-1-59259-767-3

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