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The Nature of Schizotaxia

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Early Clinical Intervention and Prevention in Schizophrenia

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Summary

In this chapter, we show that (a) schizotaxia (Meehl’s term for the predisposition to schizophrenia) is a clinically consequential condition and (b) that distinguishing it from schizotypal personality disorder (SPD) may be useful from both clinical and scientific perspectives. We review prior work indicating that some of the nonpsychotic and nonschizotypal relatives of schizophrenic patients have a psychiatric syndrome characterized by negative symptoms, neuropsychological impairment, and psychosocial dysfunction. Following Meehl, we call this constellation of clinical and neurobiologic features schizotaxia. The studies we review suggest it may be worthwhile to consider schizotaxia as a separate diagnostic class. Doing so would alert clinicians to a neurobehavioral syndrome not adequately covered by current diagnostic criteria and would motivate researchers to develop diagnostic and therapeutic approaches aimed at helping schizotaxic individuals and, perhaps, preventing the onset of schizophrenia.

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Authors
  1. Stephen V. Faraone PhD
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  2. Ming T. Tsuang MD, PhD, DSc
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  3. Sarah I. Tarbox BA
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Editor information

Editors and Affiliations

  1. Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, USA

    William S. Stone PhD , Stephen V. Faraone PhD  & Ming T. Tsuang MD, PhD, DSc ,  & 

  2. Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, Boston, MA, USA

    William S. Stone PhD

  3. Harvard Medical School Department of Psychiatry at Massachusetts General Hospital, Boston, MA, USA

    Stephen V. Faraone PhD

  4. Harvard Medical School Departments of Psychiatry at Massachusetts Mental Health Center and Massachusetts General Hospital, Boston, MA, USA

    Ming T. Tsuang MD, PhD, DSc

  5. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA

    Ming T. Tsuang MD, PhD, DSc

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© 2004 Humana Press Inc., Totowa, NJ

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Faraone, S.V., Tsuang, M.T., Tarbox, S.I. (2004). The Nature of Schizotaxia. In: Stone, W.S., Faraone, S.V., Tsuang, M.T. (eds) Early Clinical Intervention and Prevention in Schizophrenia. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-729-1_5

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  • DOI: https://doi.org/10.1007/978-1-59259-729-1_5

  • Publisher Name: Humana Press, Totowa, NJ

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