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Actions of IGF System Proteins from Studies of Transgenic and Gene Knockout Models

  • Chapter
The IGF System

Part of the book series: Contemporary Endocrinology ((COE,volume 17))

Abstract

Studies of mice that either overexpress proteins or have disrupted expression of a specific gene(s) have proven invaluable to our understanding of the actions of the insulin-like growth factors (IGF-I and IGF-II) and their primary cell-surface receptor, the type 1 IGF receptor (IGF1R). They also have provided major insights into the actions of the type 2 IGF receptor (identical to the cation-independent mannose-6-phosphate receptor; IGF2R/ci-M6PR) and the growth-promoting potential of the insulin receptor (InR). Although investigation of mice with altered IGF binding protein (IGFBP) expression has yielded important information, it has not as yet revealed comparable information regarding the fundamental actions of these proteins.

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Authors
  1. A. Joseph D’Ercole MD
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Editors and Affiliations

  1. Department of Pediatrics, School of Medicine, Oregon Health Sciences University, Portland, OR, USA

    Ron G. Rosenfeld MD

  2. Oregon Health Sciences University, Portland, OR, USA

    Charles T. Roberts Jr. PhD

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D’Ercole, A.J. (1999). Actions of IGF System Proteins from Studies of Transgenic and Gene Knockout Models. In: Rosenfeld, R.G., Roberts, C.T. (eds) The IGF System. Contemporary Endocrinology, vol 17. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-712-3_23

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  • DOI: https://doi.org/10.1007/978-1-59259-712-3_23

  • Publisher Name: Humana Press, Totowa, NJ

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