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A Primate Model of Hypertensive Cerebrovascular Disease

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Central Nervous System Diseases

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Cerebrovascular disease (CVD) in humans has been shown to produce a variety of cognitive impairments ranging from selective deficits to wide-range dementia. Among the risk factors for CVD (e.g., age, diabetes mellitus, serum lipids, obesity, cardiac disease), arterial hypertension has been identified as key(1) affecting more than 25% of the adult population of the United States (2). Gross effects of extreme hypertension are well known and include a four times greater risk for CVD than normotensive individuals(3). For the most part, hypertension is an asymptomatic disorder, but recently it has been the focus of attention on its possible detrimental effects on cognitive function. Indeed, over the past two decades, evidence has accumulated to suggest that hypertension in humans produces, in many cases, a significant impairment in several domains of cognitive function. But because of the inherent limitations of human research, even with recent advances in magnetic resonance and positron emission imaging technology, our understanding of the neurobiological basis for hypertensive related cognitive impairment is unknown. It is also unknown to what extent the changes in cognition that are associated with hypertension represent the first stage in the development of CVD and vascular dementia.

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  1. Mark B. Moss
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Editors and Affiliations

  1. Alkermes, Inc., Cambridge, MA, USA

    Dwaine F. Emerich PhD (Director of Neuroscience) (Director of Neuroscience)

  2. Department of Neuroscience, Alkermes, Inc., Cambridge, MA, USA

    Reginald L. Dean III MS

  3. University of South Florida College of Medicine, Tampa, FL, USA

    Paul R. Sanberg PhD, DSc

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Moss, M.B. (2000). A Primate Model of Hypertensive Cerebrovascular Disease. In: Emerich, D.F., Dean, R.L., Sanberg, P.R. (eds) Central Nervous System Diseases. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-691-1_21

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  • DOI: https://doi.org/10.1007/978-1-59259-691-1_21

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