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Imaging Neurologic Manifestations of Oncologic Disease

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Abstract

The advent of more effective chemotherapeutic regimens for systemic malignancies, which has afforded increased patient survival, has also resulted in a rise in the frequency of central nervous metastases and late disease complications. We are now seeing a wider variety of tumor types causing brain lesions in patients, where previously locally aggressive disease would have proved fatal (1, 2). Metastatic brain disease now affects 80,000-170,000 persons annually in the United States (3). The success of a variety of treatment approaches for single or limited brain metastases, including surgical resection, whole brain radiation, and stereotactic radiosurgery (SR), relies heavily on sensitive imaging tools. The main diagnostic tools are enhanced computed tomography (CT) or magnetic resonance imaging (MRI). However, the rapid development and refinement of structural and functional imaging acquisition and postprocessing technology have also permitted imaging approaches to be increasingly used, not only for diagnosis, but also for therapeutic planning and monitoring.

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Authors
  1. Carolyn C. Meltzer MD
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  2. Melanie B. Fukui MD
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Editors and Affiliations

  1. Department of Neurology, University of Virginia Medical Center, Charlottesville, VA, USA

    David Schiff MD

  2. Center for Neuro-Oncology Dana-Farber Cancer Institute; and Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA

    Patrick Y. Wen MD

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Meltzer, C.C., Fukui, M.B. (2003). Imaging Neurologic Manifestations of Oncologic Disease. In: Schiff, D., Wen, P.Y. (eds) Cancer Neurology in Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-317-0_19

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