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Cell Transplantation for Spinal Cord Injury Repair

  • Chapter
Neurobiology of Spinal Cord Injury

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

The annual incidence of spinal cord injury (SCI) is estimated at 30–70 cases per million in the United States (Krauss et al., 1995; Braken et al., 1981; Griffin et al., 1985). In addition to the devastating personal consequences of SCI for the individual and family, the postinjury financial costs are estimated to be in excess of 4 billion dollars (Reier et al., 1994). Postinjury intervention strategies, such as the use of steroids (Braken et al., 1990, 1997), are helping to decrease the magnitude of the deficit, but injury to the spinal cord has remained largely irreversible (Reier et al., 1994; Waxman and Kocsis, 1997; Bregman, 1998). However, recent advances in transplant strategies suggest that there may be a window of opportunity following SCI during which the introduction of heterologous cells into the injury site will promote regeneration of the injured axons.

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Authors
  1. Juan C. Bartolomei
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  2. Charles A. Greer
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Editor information

Editors and Affiliations

  1. Departments of Neurology and Pharmacology, Yale University School of Medicine, New Haven, CT, USA

    Robert G. Kalb MD

  2. Department of Neurology, Yale University School of Medicine, New Haven, CT, USA

    Stephen M. Strittmatter MD, PhD

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© 2000 Springer Science+Business Media New York

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Bartolomei, J.C., Greer, C.A. (2000). Cell Transplantation for Spinal Cord Injury Repair. In: Kalb, R.G., Strittmatter, S.M. (eds) Neurobiology of Spinal Cord Injury. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-200-5_9

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  • DOI: https://doi.org/10.1007/978-1-59259-200-5_9

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-126-4

  • Online ISBN: 978-1-59259-200-5

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