Abstract
The adult human adrenal is composed of two parts: the cortex, which is the outer part, representing 90% of its weight, and the medulla, or inner part of the gland. The adrenal cortex is made up of three zones: the zona glomerulosa (outermost), the zona fasciculata (middle), and the zona reticularis (innermost, next to the medulla). Glucocorticoids are synthesized mainly in the zona fasciculata,which constitutes 75% of the weight of the adrenal gland (Fig. 1).
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Margioris A, Gravanis A, Chrousos G. Glucocorticoids and mineralocorticoids. In: Brondy G, Lamer J, Minneman K, Neu H, eds. Human Pharmacology: molecular to clinical 2th ed., Mosby, New York, 1994, pp. 473–481.
Bamberger CM, Schulte HM, Chrousos GP. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev 1996; 17: 245–261.
Bamberger CM, Bamberger AM, de Castro M, Chrousos GP. Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 1995; 95: 2435–2441.
Koukouritaki E, Theodoropoulos P, Margioris A, Gravanis A, Stoumaras C. Dexamethasone alters rapidly actin polymerization dynamics in human endometrial cells: evidence for non-genomic actions involving cAMP turnover. J Cell Biochem 1996; 64: 251–261.
Schimmer B, Parker K. Adrenocorticotropic hormone: adrenocortical steroids and their synthetic analogs: inhibitors of the synthesis and actions of adrenocortical hormones. In: Hardman J, Limbird L, eds. The pharmacological basis of therapeutics 9th ed. McGraw-Hill, New York, 1996, pp. 1459–1485.
Gravanis A, Schaison G, George M, Satyaswaroop P, Baulieu EE, Robel P. Endometrial and pituitary responses to the steroidal antiprogestin RU486 in post-menopausal women. J Clin Endocrinol Metab 1985; 60: 156–163.
Kawal SL, Nieman L, Brandon D, Udelsman R, Loriaux DL, Chrousos GP. Pharmacokinetic properties of the antiglucocorticoid and antiprogestin steroid RU 486 in man. J Pharmacol Exp Ther 1987; 241: 401–406.
Nieman L, Chrousos GP, Kellner C, Spitz IM, Nisula B, Cutler G, et al. Successful treatment of Cushing’ s syndrome with the glucocorticoid antagonist RU 486. J Clin Endocrinol Metab 1985; 61: 536540.
Philips A, Maira M, Mullick A, Chamberland M, Lesage S, Hugo P, Drouin J. Antagonism between Nur77 and glucocorticoid receptor for control of transcription. Mol Cell Biol 1997; 17: 5952–5959.
Ray A, Prefontaine KE. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc Natl Acad Sci USA 1994; 91: 75 2756.
McKay LI, Cidlowski JA. Cross-talk between nuclear factor-kappa B and the steroid hormone receptors: mechanisms of mutual antagonism. Mol Endocrinol 1998; 12: 45–56.
Ning YM, Sanchez ER. In vivo evidence for the generation of a glucocorticoid receptor-heat shock protein-90 complex incapable of binding hormone by the calmodulin antagonist phenoxybenzamine. Mol Endocrinol 1996; 10: 14–23.
Rogatsky I, Logan SK, Garabedian MJ. Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase. Proc Natl Acad Sci USA 1998; 95: 2050–2055.
Caelles C, Gonzalez-Sancho JM, Munoz A. Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev Dec 1997; 11: 3351–3364
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Gravanis, A., Margioris, A.N. (2001). Pharmacology of Glucocorticoids: An Overview. In: Margioris, A.N., Chrousos, G.P. (eds) Adrenal Disorders. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-101-5_4
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DOI: https://doi.org/10.1007/978-1-59259-101-5_4
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