Abstract
Autoreactive B cells play a critical role in rheumatoid arthritis. These cells differentiate into long-living memory B cells and autoantibody-producing plasma cells and also present autoantigens to T cells to amplify misdirected immune responses. The therapeutic benefit of B-cell-deleting therapies suggests that B cells are emerging as important factors in the pathogenesis of RA. Aiming at evaluation of the function of B cells, which are usually derived from peripheral blood of RA patients and healthy donors, it is possible to conduct a series of experiments, such as in vitro assessment of antibody production and BCR-mediated cytokine release. These techniques can also be applied for in vivo application.
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Liu, S. (2018). Release of Antibodies and Cytokines from B Cells. In: Liu, S. (eds) Rheumatoid Arthritis. Methods in Molecular Biology, vol 1868. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8802-0_20
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DOI: https://doi.org/10.1007/978-1-4939-8802-0_20
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Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-8801-3
Online ISBN: 978-1-4939-8802-0
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